Nanotechnology-Enhanced Pharmacotherapy for Intervertebral Disc Degeneration Treatment.

Intervertebral disc degeneration (IDD) is a primary contributor to chronic back pain and disability globally, with current therapeutic approaches often proving inadequate due to the complex nature of its pathophysiology. This review assesses the potential of nanoparticle-driven pharmacotherapies to address the intricate challenges presented by IDD. We initially analyze the primary mechanisms driving IDD, with particular emphasis on mitochondrial dysfunction, oxidative stress, and the inflammatory microenvironment, all of which play pivotal roles in disc degeneration.

Human alterations of the global floodplains 1992-2019.

Floodplains provide critical ecosystem services; however, loss of natural floodplain functions caused by human alterations increase flood risks and lead to massive loss of life and property. Despite recent calls for improved floodplain protection and management, a comprehensive, global-scale assessment quantifying human floodplain alterations does not exist. We developed the first publicly available global dataset that quantifies human alterations in 15 million km floodplains along 520 major river basins during the recent 27 years (1992-2019) at 250-m resolution.

The changing face of floodplains in the Mississippi River Basin detected by a 60-year land use change dataset.

Floodplains provide essential ecosystem functions, yet >80% of European and North American floodplains are substantially modified. Despite floodplain changes over the past century, comprehensive, long-term land use change data within large river basin floodplains are limited. Long-term land use data can be used to quantify floodplain functions and provide spatially explicit information for management, restoration, and flood-risk mitigation.

[Application of composite tissue flaps pedicled with distal perforating branch of posterior tibial artery for repairing distal leg defects].

Objective: To investigate the clinical application and effectiveness of the composite tissue flaps pedicled with perforating branch of posterior tibial artery for repairing distal leg defects.

Methods: Between September 2014 and August 2017, 12 patients with skin and bone defects of distal leg were repaired with the composite tissue flaps pedicled with perforating branch of posterior tibial artery. There were 8 males and 4 females with an average age of 41.

α-hemihydrate calcium sulfate/octacalcium phosphate combined with sodium hyaluronate promotes bone marrow-derived mesenchymal stem cell osteogenesis in vitro and in vivo.

Purpose: The aims of this research were to combine α-hemihydrate calcium sulfate/octacalcium phosphate (α-CSH/OCP) with sodium hyaluronate (SH) or SH sulfate (SHS) to determine whether these composites can be used as a new type of bone repair material. This study may provide a theoretical basis and new ideas for the construction of active bone repair materials and their clinical application.

Methods: In this study, we combined α-CSH/OCP with SH or SHS.