Publications by authors named "Qianhua Cao"
Article Synopsis
- Basal-like breast cancer (BLBC) is the most aggressive subtype of breast cancer, and this study investigates the role of AMD1 overexpression in promoting its aggressiveness.
- The researchers found that increased levels of AMD1 in BLBC were linked to factors such as promoter hypomethylation and transcription activity of Sox10, which together enhance spermidine production, leading to increased tumor cell proliferation.
- The study concludes that the AMD1-mediated pathway involving spermidine and TCF4 is crucial for the aggressiveness of BLBC, suggesting it could serve as a potential prognostic indicator and therapeutic target.
Basal-like breast cancer (BLBC) is the most aggressive subtype with poor prognosis; however, the mechanisms underlying aggressiveness in BLBC remain poorly understood. In this study, we showed that in contrast to other subtypes, inositol monophosphatase 2 (IMPA2) was dramatically increased in BLBC. Mechanistically, IMPA2 expression was upregulated due to copy number amplification, hypomethylation of IMPA2 promoter and MYC-mediated transcriptional activation.
View Article and Find Full Text PDFBackground: Basal-like breast cancer (BLBC) is the most aggressive subtype of breast cancer because of its aggressive biological characteristics and no effective targeted agents. However, the mechanism underlying its aggressive behavior remain poorly understood. β1,3-N-acetylglucosaminyltransferase V (B3GNT5) overexpression occurs specifically in BLBC.
View Article and Find Full Text PDFBackground: Basal-like breast cancer (BLBC) is associated with a poor clinical outcome; however, the mechanism of BLBC aggressiveness is still unclear. It has been shown that a linker histone functions as either a positive or negative regulator of gene expression in tumors. Here, we aimed to investigate the possible involvement and mechanism of HIST1H1B in BLBC progression.
View Article and Find Full Text PDFBasal-like breast cancer (BLBC) is associated with high grade, distant metastasis, and poor prognosis; however, the mechanism underlying aggressiveness of BLBC is still unclear. Emerging evidence has suggested that phospholipid scramblase 1 (PLSCR1) is involved in tumor progression. Here, we aimed to study the possible involvement and molecular mechanisms of PLSCR1 contributing to the aggressive behavior of BLBC.
View Article and Find Full Text PDFBasal-like breast cancer (BLBC) is the most aggressive subtype with a poor clinical outcome; however, the molecular mechanisms underlying aggressiveness in BLBC remain poorly understood. The effects of gamma-aminobutyrate aminotransferase (ABAT) on GABA receptors, Ca-NFAT1 axis, and cancer cell behavior were assessed by Ca imaging, Western blotting, immunostaining, colony formation, and migration and invasion assays. We elucidated the relationship between ABAT and Snail by luciferase reporter and ChIP assays.
View Article and Find Full Text PDFBasal-like breast cancer (BLBC) is associated with a poor clinical outcome due to the few treatment options and absence of effective targeted agents. Here, we show that malic enzyme 1 (ME1) is dramatically upregulated in BLBC due to ME1 copy number amplification. ME1 expression increases glucose uptake and lactate production, and reduces oxygen consumption, leading to aerobic glycolysis.
View Article and Find Full Text PDFBasal-like breast cancer (BLBC) is associated with a poor clinical outcome as a result of the few treatment options and poor therapeutic response. Here, we report that elevated expression of urine diphosphate-galactose ceramide galactosyltransferase (UGT8) specifically occurs in BLBC and predicts poor prognosis in breast cancer patients. UGT8 expression is transcriptionally up-regulated by Sox10, triggering the sulfatide biosynthetic pathway; increased sulfatide activates integrin αVβ5-mediated signaling that contributes to BLBC progression.
View Article and Find Full Text PDFBasal-like breast cancer (BLBC) is associated with high-grade, distant metastasis and poor prognosis. Elucidating the determinants of aggressiveness in BLBC may facilitate the development of novel interventions for this challenging disease. In this study, we show that aldo-keto reductase 1 member B1 (AKR1B1) overexpression highly correlates with BLBC and predicts poor prognosis in breast cancer patients.
View Article and Find Full Text PDFArticle Synopsis
- Hydrogen sulfide (H2S) and hydrogen peroxide (H2O2) are crucial signaling molecules that help Arabidopsis plants cope with salt stress, particularly at high concentrations of NaCl (100 mM).
- H2S enhances salt tolerance by maintaining a favorable Na(+)/K(+) ratio and promoting root growth, while its effects are closely linked to H2O2 production and the activity of specific enzymes.
- The study shows that H2S regulates important proteins involved in ion transport, like PM H(+)-ATPase and Na(+)/H(+) antiporter, in a way that relies on H2O2 levels, indicating a complex signaling network critical for plant salt resistance.