Exploration and Practice of the "One Combination, Two Highlights, Three Combinations, Four in One" Innovative Talents Training Mode in Forensic Medicine.

Talent is one of the basic and strategic supports for building a modern socialist country in all aspects. Since the 1980s, the establishment of forensic medicine major and the cultivation of innovative talents in forensic medicine have become hot topics in higher education in forensic medicine. Over the past 43 years, the forensic medicine team of Shanxi Medical University has adhered to the joint education of public security and colleges, and made collaborative innovation, forming a training mode of "One Combination, Two Highlights, Three Combinations, Four in One" for innovative talents in forensic medicine.

Effects of phosphorus application on yield, quality and phosphorus use efficiency of edible sweetpotato: A case study of Xushu 32.

To explore the appropriate amount of phosphorus (P) fertilizer and improve economic yield and P use efficiency of edible sweetpotato, we took Xushu 32 as an example and compared the effects of different P application rates on yield, quality, P accumulation and P use efficiency of edible sweetpotato based on a two-year field experiment (soil available P content was 31.70 mg·kg) from 2018 to 2019. There were five P application levels (PO), including 0 (P), 25 (P), 50 (P), 75 (P) and 100 kg·hm(P).

A new kind of filter paper comprising ultralong hydroxyapatite nanowires and double metal oxide nanosheets for high-performance dye separation.

Simultaneous enhancement in water flux and removal efficiency during the filtration process remains a big challenge for separation membranes. The porous structure of the filter paper can provide many channels for water transportation, but the separation performance is generally poor. The purpose of this study is to develop a new kind of filter paper consisting of ultralong hydroxyapatite (HAP) nanowires, cellulose fibers (CFs) and double metal oxide (LDO) nanosheets, and to achieve the simultaneous enhancement of both water flux and removal efficiency for high-performance dye separation.

A national survey on fungal infection diagnostic capacity in the clinical mycology laboratories of tertiary care hospitals in China.

Background/purpose: As the incidence of fungal infections in China increases, the demand for rapid and accurate diagnosis of mycoses is growing. Yet, information on current diagnostic capacity is scarce.

Methods: An online survey was conducted in February 2018 to collect information on mycology testing from tertiary care hospitals across China.

Differences in interactions between macrophages with pathogenic and environmental strains of .

We investigated the interactions between macrophage and different strains of . J774A.1 macrophages were infected with clinical isolates of 18125 and 50779 and environmental isolate of  N71.

A new kind of nanocomposite Xuan paper comprising ultralong hydroxyapatite nanowires and cellulose fibers with a unique ink wetting performance.

In the history of civilization, Xuan paper with its superior texture, durability and suitable characteristics for writing and painting, has played an important role in the dissemination of culture and art. Xuan paper has won the reputation of "the king of paper that lasts for 1000 years" and was inscribed on the Representative List of the Intangible Cultural Heritage of Humanity by the Educational, Scientific and Cultural Organization of the United Nations in 2009. However, the surface of the commercial unprocessed Xuan paper has a large number of large-sized pores with a poor resistance to water, allowing ink droplets to easily spread during the writing and painting process.

Epidural Spinal Cord Stimulation Promotes Motor Functional Recovery by Enhancing Oligodendrocyte Survival and Differentiation and by Protecting Myelin after Spinal Cord Injury in Rats.

Epidural spinal cord stimulation (ESCS) markedly improves motor and sensory function after spinal cord injury (SCI), but the underlying mechanisms are unclear. Here, we investigated whether ESCS affects oligodendrocyte differentiation and its cellular and molecular mechanisms in rats with SCI. ESCS improved hindlimb motor function at 7 days, 14 days, 21 days, and 28 days after SCI.

Secret Paper with Vinegar as an Invisible Security Ink and Fire as a Decryption Key for Information Protection.

Security inks based on photoluminescent materials are mostly investigated for security applications, such as information encryption and decryption, anti-counterfeiting, and data storage. Although they are invisible to the naked eye under ambient light, they can be detected under ultraviolet or near-infrared light. Herein, a new kind of secret paper made from network-structured ultralong hydroxyapatite nanowires and cellulose fibers has been developed.

Kinetic host defense of the mice infected with .

is one of the most common opportunistic fungi that can cause invasive infection. To profile the kinetic variation of immune cells and cytokines after exposure to thoroughly, we established a pulmonary infection model in temporarily immunosuppressed mice. Systematic and kinetic studies of different immune cells and cytokines were performed.

Comparative Genome and Transcriptome Study of the Gene Expression Difference Between Pathogenic and Environmental Strains of .

commonly exists in the environment, and causes invasive infections (protothecosis) in humans. The morbidity of protothecosis has increased rapidly in recent years, especially in systemic infections of patients with an impaired immune system. The infection in immunocompromised patients has a poor prognosis due to limited understanding of the pathogenesis of the disease, as most previous studies mainly focused on classification and recognition of pathogenic strains.

Ultralong Hydroxyapatite Nanowire-Based Filter Paper for High-Performance Water Purification.

A new kind of environmentally friendly filter paper based on ultralong hydroxyapatite nanowires (HAPNWs) and cellulose fibers (CFs) with excellent filtration and adsorption properties has been developed for the application in high-performance water purification. The use of polyamidoamine-epichlorohydrin (PAE) resin increases the wet mechanical strength of the as-prepared HAPNW/CF filter paper. The addition of CFs enhances the mechanical strength of the HAPNW/CF filter paper.

Isobaric tag for relative and absolute quantitation-based comparative proteomic analysis of human pathogenic Prototheca zopfii genotype 2 and environmental genotype 1 strains.

Background/purpose: Prototheca species are ubiquitous achlorophyllic microalgae belonging to the family Chlorellaceae, which can cause a wide range of infections in humans and animals. Mainly in individuals with immunologic defects or trauma, Prototheca spp. can cause even lethal diseases.

In vitro and in vivo evidence for amphotericin B as a P-glycoprotein substrate on the blood-brain barrier.

Amphotericin B (AMB) has been a mainstay therapy for fungal infections of the central nervous system, but its use has been limited by its poor penetration into the brain, the mechanism of which remains unclear. In this study, we aimed to investigate the role of P-glycoprotein (P-gp) in AMB crossing the blood-brain barrier (BBB). The uptake of AMB by primary brain capillary endothelial cells in vitro was significantly enhanced after inhibition of P-gp by verapamil.

Identification of clinically relevant fungi and prototheca species by rRNA gene sequencing and multilocus PCR coupled with electrospray ionization mass spectrometry.

Background: Multilocus PCR coupled with electrospray ionization mass spectrometry (PCR/ESI-MS) is a new strategy for pathogen identification, but information about its application in fungal identification remains sparse.

Methods: One-hundred and twelve strains and isolates of clinically important fungi and Prototheca species were subjected to both rRNA gene sequencing and PCR/ESI-MS. Three regions of the rRNA gene were used as targets for sequencing: the 5' end of the large subunit rRNA gene (D1/D2 region), and the internal transcribed spacers 1 and 2 (ITS1 and ITS2 regions).

Cutaneous protothecosis in patient with diabetes mellitus and review of published case reports.

Protothecosis is an opportunistic infection caused by Prototheca, usually called as saprophytes, and is frequently found in natural and living surroundings with low virulence, but may cause chronic infection in immunocompromised individuals. We report a case of cutaneous protothecosis with zopfii var. portoricensis infection in a 66-year-old diabetic woman following hand surgery on middle right finger.

[Antifungal susceptibility test of genotypes of Candida albicans from patients with atrophic or erosive oral lichen planus].

Purpose: To study the antifungal susceptibility of genotypes of Candida albicans from patients with atrophic or erosive oral lichen planus and provide evidence for the treatment of candidiasis.

Methods: Polymerase chain reaction(PCR) was adopted to analyze 101 Candida albicans which were isolated from atrophic or erosive oral lichen planus.Microdilution broth method was carried out for antifungal susceptibility test.

Suction blister epidermal grafting using a modified suction method in the treatment of stable vitiligo: a retrospective study.

Background: Of various surgical therapies used for the replenishment of melanocytes in recalcitrant and stable vitiligo, suction blister epidermal grafting (SBEG) is one of the simplest and most effective methods.

Objective: To evaluate the effectiveness and potential complications of SBEG in the treatment of stable vitiligo through the use of a modified dermis-epidermis separator designed by the authors.

Materials And Methods: One thousand one hundred people with stable vitiligo unresponsive to other medical treatments were treated with SBEG therapy.

Cutaneous malasseziasis: four case reports of atypical dermatitis and onychomycosis caused by Malassezia.

Background: This study investigates four special cases associated with Malassezia.

Methods: The special clinical manifestations, mycologic examination, and treatment were reviewed intensively.

Results: An abundance of Malassezia hyphae were found in the scales of the three cases presenting with erythematous patches and in another case presenting with dystrophic nails.

Cryptococcal meningitis in non-HIV-infected patients in a Chinese tertiary care hospital, 1997-2007.

Information remains sparse about non-HIV patients with cryptococcal meningitis in the era of triazole therapy. Particularly of interest are the clinical manifestations and prognosis of the infection in these previously healthy patients. We retrospectively reviewed 154 non-HIV-infected patients with cryptococcal meningitis who presented in our hospital from 1997 to 2007.

[The polymorphism of cytochrome P(450) 2C19 gene in patients with invasive fungal infections.].

Objective: To investigate the polymorphism profile of cytochrome P(450) 2C19 (CYP2C19) in Chinese patients with invasive fungal infections.

Methods: Two major single nucleotide polymorphism loci of the CYP2C19 gene (CYP2C19*2 and CYP2C19*3) were genotyped with PCR and restriction fragment length polymorphism (PCR-RFLP) in 134 patients with invasive fungal infections and 134 healthy volunteers. Allele frequencies and the proportions of metabolizer phenotypes were compared.

Meningitis due to Prototheca wickerhamii: rare case in China.

A rare case of Prototheca wickerhamii meningitis is reported in a patient without any underlying immunodeficient condition. Wet-mount microscopy and culture of cerebral spinal fluid specimens, along with temperature resistance, cycloheximide tolerance, carbohydrates assimilation, including API 20C AUX tests of the isolated etiologic agent were performed. In addition, transmission and scanning electron microscopy studies and in vitro antifungal susceptibility tests were conducted.