Exploring the conformational dynamics and thermodynamics of S768I and G719X + S768I mutations in non-small cell lung cancer: An approaches.

Non-small cell lung cancer (NSCLC) is often driven by mutations in the epidermal growth factor receptor () gene. However, rare mutations such as G719X and S768I lack standard anti-EGFR targeted therapies. Understanding the structural differences between wild-type EGFR and these rare mutants is crucial for developing EGFR-targeted drugs.