Glucose-regulated protein 78 regulates the subunit-folding of the CCT complex by modulating gene expression and protein interaction in the microsporidian Nosema bombycis.

Chaperonin containing tailless complex polypeptide 1 (CCT) functions as a molecular chaperone and is essential for ensuring proper protein folding. Glucose-regulated protein 78 (GRP78/Bip), also a type of chaperone, not only assists in folding of proteins, but also facilitates the transportation of proteins into the endoplasmic reticulum (ER) via the Sec protein complex. In this study, we identified the CCTη of N.

Textile-Based TENG Woven with Fluorinated Polyimide Yarns for Motion and Position Monitoring.

Polyimide-based triboelectric nanogenerators (TENGs) capable of energy harvesting in harsh environments (high temperature and high humidity) have been extensively studied. However, most polyimide-based TENGs have the disadvantages of poor air permeability and poor softness. In this study, a core-shell yarn with good air permeability, softness, and high electric output performance was successfully prepared by conjugate electrospinning.

Association of different types of milk with depression and anxiety: a prospective cohort study and Mendelian randomization analysis.

Background: The relationship between different types of milk and depression and anxiety remains unclear, with limited evidence from prospective cohort studies. This study aims to evaluate this relationship using data from the UK Biobank cohort and to explore its potential causality through Mendelian randomization (MR) analysis.

Methods: Cox proportional hazards models were used to assess the association between different milk types and the risk of depression and anxiety among 357,568 UK Biobank participants free of these conditions at baseline.

Ultra-Broadband Perfect Absorbers Based on Biomimetic Metamaterials with Dual Coupling Gradient Resonators.

Ultra-broadband metamaterial absorbers can achieve near-perfect absorption of omnidirectional electromagnetic waves, crucial for light utilization and manipulation. Traditional ultra-broadband metamaterials rely on the superposition of different resonator units either in the plane or in perpendicular directions to broaden absorption peaks. However, this approach is subject to quantity restrictions and complicates the fabrication process.

Unveiling Active Al Sites for Ethanol Dehydration on γ-AlO with Solid-State Nuclear Magnetic Resonance Spectroscopy.

γ-AlO is a crucial catalyst widely used in industrial alcohol dehydration processes. However, the specific nature of its active sites has remained unclear. In this study, we utilize two-dimensional heteronuclear correlation solid-state nuclear magnetic resonance and density functional theory calculations to uncover the active Al sites on the surface of γ-AlO that facilitate ethanol dehydration.

Near infrared laser precisely controlled ultrafast superhydrophilicity-to-hydrophobicity transition of copper sulfide nanosphere coating on cellulose fiber fabric.

Inspired by lotus leaf, biomimetic hydrophobic cellulose fiber-based textiles were usually fabricated by the lower surface energy materials. However, it is rare to witness a hydrophobic surface obtained by near infrared laser (NIR) irradiation a superhydrophilic nanomaterial, which remains a huge challenge. Herein, the CuS nanospheres was in-situ anchored on the surface of gallic acid self-polymer treated cotton fabric.

Corrosion fatigue of as-extruded Mg-xGa alloys in simulated bodily fluids with various glucose contents.

The medical devices are subjected to dynamic loads and surrounding physiological condition of the bodily fluids, which will impact the degradation behavior of magnesium (Mg) alloy implants. In this work, the corrosion fatigue (CF) and corrosion behaviors of Mg-xGa (x = 1, 1.5, and 2 wt%) alloys in Hank's balanced salt solutions (HBSS) with 1 g/L and 3 g/L glucose are thoroughly studied.

Dissecting the Predictors of Cyber-Aggression Through an Explainable Machine Learning Model.

The general aggression model (GAM) suggests that cyber-aggression stems from individual characteristics and situational contexts. Previous studies have focused on limited factors using linear models, leading to oversimplified predictions. This study used the light gradient boosting machine (LightGBM) to identify and rank the importance of various risk and protective factors in cyber-aggression.

BP-3 exposure at environmentally relevant concentrations induced male developmental reproductive toxicity via ER/CCL27/ROS pathway in mice.

BP-3 is the most widely used ultraviolet absorber, but its toxic effects and mechanisms far from being elucidated. This study evaluated the male developmental reproductive toxicities and mechanism of low-doses of BP-3. The results indicated that BP-3 (2.

Near-infrared downshifting luminescence of CaLaTaO:Nd/Yb/K phosphors and their applications: solar cells and anti-counterfeiting.

A series of Nd/Yb co-doped CaLaTaO (CLTO) phosphors are synthesized by a high temperature solid phase method. Structural characterization confirms the successful incorporation of Nd and Yb ions into the CLTO host lattice. The photoluminescence excitation (PLE) spectra and photoluminescence (PL) spectra of CLTO:Nd and CLTO:Nd/Yb are investigated in detail.

Synthesis of 3-propargyl isoindolinones by Pd/Cu-catalyzed enantioselective Heck/Sonogashira reaction of enamides.

Herein, we report an enantioselective Pd/Cu-catalyzed sequential Heck/Sonogashira coupling reaction of electron-rich enamides with terminal alkynes as substrates. This transformation proceeds smoothly to afford 3-propargyl isoindolinone derivatives bearing quaternary stereogenic centers in moderate to good yields (43-77% yield) and good to excellent enantioselectivity (up to 93% ee). Functional groups such as halogen atoms (F, Cl, and Br), thienyl, and silyl moieties are tolerated well.

Perioperative tislelizumab with four cycles of neoadjuvant chemotherapy for resectable locally advanced esophageal squamous cell carcinoma: a phase 2 study.

Background: The application of neoadjuvant immunotherapy in the treatment of esophageal cancer needs further exploration. This study aimed to investigate the safety and effectiveness of tislelizumab, an anti-PD-1 antibody, combined with chemotherapy as neoadjuvant treatment for locally advanced esophageal squamous cell carcinoma (LA-ESCC).

Methods: In this phase II study, patients with clinical stages of II-IVA (T3-T4 and/or node positive) potentially resectable LA-ESCC were enrolled.

The SnRK2.2-ZmHsf28-JAZ14/17 module regulates drought tolerance in maize.

Abscisic acid (ABA) and jasmonic acid (JA) are important plant hormones in response to drought stress. We have identified that ZmHsf28 elevated ABA and JA accumulation to confer drought tolerance in maize; however, the underlying mechanism still remains elusive. The knockout line zmhsf28 is generated to confirm the positive role of ZmHsf28 in drought response.

Physiological Mechanism of EBR for Grain-Filling and Yield Formation of Tartary Buckwheat.

Tartary buckwheat is characterized by its numerous inflorescences; however, the uneven distribution of resources can lead to an overload in certain areas, significantly limiting plant productivity. Plant growth regulators effectively modulate plant growth and development. This study investigated the effects of three concentrations of brassinosteroids (EBR) on the Tartary buckwheat cultivar with high seed-setting rates, specifically Chuanqiao No.

One to All: Toward a Unified Model for Counting Cereal Crop Heads Based on Few-Shot Learning.

Accurate counting of cereals crops, e.g., maize, rice, sorghum, and wheat, is crucial for estimating grain production and ensuring food security.

Phlecarinatones H-N: Abietane-type diterpenoids from Phlegmariurus carinatus with proliferative inhibitory effect on U251 glioblastoma cells.

Thirteen abietane-type diterpenoids, including seven previously undescribed compounds and six known analogs, were isolated from the root and aerial parts of Phlegmariurus carinatus. Their structures were elucidated by comprehensive spectroscopic data analysis (UV, IR, NMR, and HRESIMS) and quantum chemical calculations (calculated ECD or C NMR). Notably, these compounds exhibited high structural diversity.

Global trends of schistosomiasis burden from 1990 to 2021 across 204 countries and territories: Findings from GBD 2021 study.

Introduction: The WHO aims to eliminate schistosomiasis as a public health problem by 2030. Based on the Global Burden of Disease 2021 (GBD 2021), this study assesses the global distribution of schistosomiasis burden to guide policy and resource allocation.

Methods: Schistosomiasis burden and social-demographic indexes (SDIs) data were extracted from GBD 2021 study.

Kaempferol Improved Rheumatoid Arthritis by Regulating the Immune Imbalance of Treg/Th17.

Objective: The objective of this study was to explore the therapeutic effects of kaempferol (Kae) on rheumatoid arthritis (RA) and to elucidate the underlying mechanisms.

Methods: The collagen-induced arthritis (CIA) model was established using collagen II to induce RA. Mice were treated with Kae at a dose of 25 or 50 mg/kg/day via gavage.

Palladium-Catalyzed Autotandem Ring-Opening of Cyclopropanols with Gem-Dibromoolefins for the Synthesis of β-Pyrrolo[1,2-]quinolinyl Ketones.

Herein, the palladium-catalyzed autotandem reaction of cyclopropyl alcohols with gem-dibromoolefins is described. This reaction system involves two distinct mechanistic processes, both efficiently catalyzed by the same palladium catalyst. This approach accommodates a wide substrate scope using readily available starting materials, offering a new and efficient method for synthesizing a series of β-pyrrolo[1,2-]quinolinyl ketones.

A novel annexin dimer targets microglial phagocytosis of astrocytes to protect the brain-blood barrier after cerebral ischemia.

Despite the vital role of astrocytes in preserving blood-brain barrier (BBB) integrity, their therapeutic potential as targets in ischemic stroke-induced barrier disruption remains underexplored. We previously reported externalization of phosphatidylserine (PS) on astrocytic membranes concurrent with the emergence of PS externalization in neurons. PS externalization of astrocytes induced microglial phagocytosis of astrocytes, resulting in reduced astrocyte-vascular coupling and subsequent BBB breakdown.

CRMP2 regulates mossy fiber sprouting and modulates microtubule dynamics in a pilocarpine induced rat model of epilepsy.

Objective: Our study aimed to investigate the role of CRMP2 in mossy fiber sprouting (MFS) using a pilocarpine-induced rat model of epilepsy.

Methods: First, the rats were sacrificed on the 1, 7, 14 and 28 day after pilocarpine injection. Quantitative Real-time PCR (qPCR) and Western blot (WB) were performed to assess mRNA and protein levels in the hippocampus and cortex.

Corrigendum: Case report: A golden tail of immunotherapy: significant tail effect in a chemotherapy-resistant advanced pulmonary sarcomatoid carcinoma patient treated by Sintilimab combined with Anlotinib.

[This corrects the article DOI: 10.3389/fimmu.2024.

Atypical carcinoid of the primary kidney with retroperitoneal metastasis 15 years later: A case report and literature review.

Primary renal neuroendocrine tumors (NETs) are extremely rare among renal malignancies. According to pathological manifestations, carcinoid can be divided into four types: typical carcinoid, atypical carcinoid, large cell and small cell neuroendocrine carcinoma. Primary or secondary retroperitoneal carcinoid is even rarer than renal carcinoid.