Bioactive surface-functionalized MXenes for biomedicine.

MXenes, with their good biocompatibility, excellent photovoltaic properties, excellent physicochemical properties, and desirable bioactivity, have broad application prospects in the field of tissue regeneration. MXenes have been used in a wide range of applications including biosensing, bioimaging, tumour/infection therapy, bone regeneration and wound repair. By applying bioactive materials to modify the surface of MXenes, a series of multifunctional MXene-based nanomaterials can be designed for different biomedical applications to achieve better therapeutic effects or more desirable biological functions.

Supporting vision-language model few-shot inference with confounder-pruned knowledge prompt.

Vision-language models are pre-trained by aligning image-text pairs in a common space to deal with open-set visual concepts. Recent works adopt fixed or learnable prompts, i.e.

Risk factors and prediction model of breast cancer-related lymphoedema in a Chinese cancer centre: a prospective cohort study protocol.

Introduction: Lymphoedema is a distressing and long-term complication for breast cancer survivors. However, the reported incidence of lymphoedema varies, and its risk factors remain underexplored. Currently, a well-established risk prediction model is still lacking.

The Prognostic Value of Right Ventricular End-Diastolic Basal Diameter Index by Echocardiography in Connective Tissue Diseases Associated With Pulmonary Artery Hypertension.

Background: Right ventricular (RV) failure is a well-recognized pivotal prognostic factor of adverse outcomes in pulmonary artery hypertension (PAH), while RV dilation provides significant implications for adaptive or maladaptive changes. PAH is a predominant cause of mortality among patients with connective tissue disease (CTD). This study aims to elucidate the prognostic significance of RV morphology, as assessed by echocardiography (ECHO), in with CTD associated with PAH (CTD-PAH).

Corticomuscular coherence existed at the single motor unit level.

The monosynaptic cortico-motoneuronal connections suggest the possibility of individual motor units (MUs) receiving independent commands from motor cortex. However, previous studies that used corticomuscular coherence (CMC) between electroencephalogram (EEG) signals and electromyogram (EMG) signals have not directly explored the corticospinal functionality at the single motoneuron level. The objective of this study is to find out whether synchronous activities exist between the motor cortex and individual MUs.

Metabolomic studies reveal and validate potential biomarkers of diabetic retinopathy in two Chinese datasets with type 2 diabetes: a cross-sectional study.

Background: Diabetic retinopathy (DR) is a major microvascular complication of diabetes mellitus and causes vision impairment and blindness. The presence of major risk factors for DR, such as high levels of HbA1c, does not predict all DR pathogenesis in the clinic, which suggests that uncovering the underlying mechanisms and identifying novel markers are needed. Previous evidence has shown that the serum metabolic signature of DR is unique and detectable compared with that of diabetes mellitus (DM).

Perceptions, beliefs, and anticipations regarding living wills among Master's degree nursing students in China: an exploratory qualitative study.

Background: Steeped in cultural heritage, the Chinese traditionally equate death with misfortune. This deeply rooted belief has led to a low rate of living will signings and poses challenges for implementing death education. Master's degree nursing students are instrumental in facilitating and promoting the adoption of living wills, leveraging their specialized knowledge in providing compassionate care.

Isolation and manipulation of meiotic spindles from mouse oocytes reveals migration regulated by pulling force during asymmetric division.

Spindles are essential for accurate chromosome segregation in all eukaryotic cells. This study presents a novel approach for isolating fresh mammalian spindles from mouse oocytes, establishing it as a valuable model system for a wide range of possible studies. Our method enables the investigation of the physical properties and migration force of meiotic spindles in oocytes.

Stanniocalcin-1 in tumor immunity: acts via macrophages.

Tumor immune escape has become a research hotspot in the field of cancer immunotherapy. Tumor-associated macrophages (TAMs) are the key component of tumor microenvironment, which play a pivotal role in tumor immune escape by regulating the immunity checkpoints, inhibiting the activity of T lymphocytes and natural killer (NK) cells, and modulating proportion of different T cells. Stanniocalcin-1(STC1)is ubiquitously expressed in human body, which is proven to involve with tumor progression and clinical prognosis.

A comprehensive review of antibiotics stress on anammox systems: Mechanisms, applications, and challenges.

Anaerobic ammonia oxidation (anammox), an energy-efficient technology for treating ammonium-rich wastewater, faces the challenge of antibiotic stress in sewage. This paper systematically evaluated the impact of antibiotics on anammox by considering both inhibitory effects and recovery duration. This review focused on cellular responses, including extracellular polymeric substances (EPS), quorum sensing (QS), and enzymes.

The role of DDR1 in cancer and the progress of its selective inhibitors.

Discoidin domain receptor 1 (DDR1) is a member of the receptor tyrosine kinase superfamily, which mainly activates downstream signaling pathways through binding to collagen. The abnormal expression of DDR1 is closely related to the occurrence and development of various tumors, and it is one of the potential targets for molecular targeted therapy. At present, specific antibodies and selective small molecule inhibitors against DDR1 have been approved for Phase I clinical trials.

[BCMA chimeric antigen receptor T cells therapy re-treatment of a patient with recurrent/refractory IgD multiple myeloma: A case report and literature review].

Multiple myeloma (MM) is a malignant plasma cell disease that currently cannot be cured. Several new drugs have continuously been introduced in the recent years. New drugs targeting B-cell maturation antigen (BCMA) have greatly improved the efficacy and prognosis of MM compared with traditional treatments.

The Role of Cholesterol during the Ovarian Maturation and Lipid Metabolism of Female Chinese Mitten Crab ().

In previous study, we found that the cholesterol requirement of was 0.27%, to further investigate the effects of cholesterol on health status, ovarian maturation, and lipid metabolism of female broodstock. Two diets containing 0% and 0.

Transformative applications of oculomics-based AI approaches in the management of systemic diseases: A systematic review.

Background: Systemic diseases, such as cardiovascular and cerebrovascular conditions, pose significant global health challenges due to their high mortality rates. Early identification and intervention in systemic diseases can substantially enhance their prognosis. However, diagnosing systemic diseases often necessitates complex, expensive, and invasive tests, posing challenges in their timely detection.

Haploid-Phased Chromosomal Telomere-to-Telomere Genome Assembly of Medicinal Plant Uncaria rhynchophylla Dissects Genetic Controls on the Biosynthesis of Bioactive Alkaloids.

Natural indole alkaloids provide important medicinal resources and defences to environmental stresses. The Uncaria genus is a recorded traditional medicinal woody plant with high alkaloids. Genomic insights into alkaloid variation remain elusive.

Lower Free Thyroxine Levels Are Associated with Diabetic Kidney Disease in Males with Type 2 Diabetes Mellitus: An Observational Cross-Sectional Study.

: We aimed to explore the correlation between thyroid function and diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM). : A total of 7516 T2DM patients were enrolled and grouped according to DKD status. Clinical parameters, including blood glucose parameters, thyroid function, and indicators of renal impairment, were collected and compared between the DKD and Non-DKD groups.

Phytochrome interacting factor 3 mediates low light signaling to regulate isorhynchophylline biosynthesis in Uncaria rhynchophylla.

Phytochrome interacting factors (PIFs) serve as crucial regulators in the light signal transduction pathway and also mediate light signals to regulate secondary metabolite synthesis in plants. However, the regulator role of PIFs in secondary metabolites often varies among different plants. Isorhynchophylline (IRN), an iconic secondary metabolite of Uncaria rhynchophylla, holds significant medicinal value.

Exploring the impacts of high-speed rail on technology-intensive manufacturing: the case of the Yangtze River Delta region, 2007-2016.

High-speed rail (HSR) may influence economic activities that rely heavily on innovation by facilitating skilled labour, face-to-face interactions, and knowledge spillovers. This study explores how HSR development affects the spatial distribution of technology-intensive manufacturing (TIM) in the Yangtze River Delta (YRD), China. Using a panel dataset including 24 cities for the period 2007-2016 and employing the output of communications equipment, computers, and other electronic equipment (CCOE) as a proxy for TIM's economic productivity at the city level, we apply the staggered difference-in-differences (DID) and spatial Durbin model (SDM) to measure the impacts of HSR's initial opening and connectivity on CCOE development and capture the spatial spillover effects of HSR connectivity.

Nitrogen plasma-induced phase engineering and titanium carbide/carbon nanotubes dual conductive skeletons endow molybdenum disulfide with significantly improved lithium storage performance.

MoS/TiC MXene composite has emerged as a promising anode material for lithium storage due to the synergistic combination of high specific capacity offered by MoS and conductive skeleton provided by TiC MXene. However, its two-dimensional/two-dimensional (2D/2D) structure is susceptible to collapse after long cycles, while the inherent low conductivity of MoS limits its rate performance. In this study, we developed a novel approach combining plasma-induced phase engineering with dual skeleton structure design to fabricate a unique P-MoS/TiC/CNTs anode material featuring highly conductive 1T phase MoS and a stable one-dimensional/two-dimensional (1D/2D) architecture.

Preoperative inter-arm differences and normative-based thresholds for lymphedema in Chinese breast cancer patients: Insights from a large cohort study.

Objective: Early detection and diagnosis of lymphedema are crucial for effective treatment and prevention of its progression. Normative-based diagnostic thresholds can enhance diagnostic accuracy in the absence of preoperative measurements. This study aimed to investigate preoperative inter-arm differences and the associated factors, as well as to determine normative-based thresholds for lymphedema in Chinese breast cancer patients.