Spinel-Based ZnAlO: 0.5%Cr Red Phosphor Ceramics for WLED.

To address the issue of the lack of red light in traditional Ce: YAG-encapsulated blue LED white light systems, we utilized spark plasma sintering (SPS) to prepare spinel-based Cr-doped red phosphor ceramics. Through phase and spectral analysis, the SPS-sintered ZnAlO: 0.5%Cr phosphor ceramic exhibits good density, and Cr is incorporated into [AlO] octahedra as a red emitting center.

Color Tunable Composite Phosphor Ceramics Based on SrAlSiN:Eu/LuAlO:Ce for High-Power and High-Color-Rendering-Index White LEDs/LDs Lighting.

LuAlO:Ce phosphor ceramics were fabricated by vacuum sintering. On this basis, a bi-layer composite phosphor was prepared by low-temperature sintering to cover the phosphor ceramics with a layer of SrAlSiN:Eu-phosphor-in-glass (PiG). The optical, thermal, and colorimetric properties of LuAG:Ce phosphor ceramics, SrAlSiN:Eu phosphors and SrAlSiN:Eu-PiG were studied individually.

PARP1 promotes NLRP3 activation via blocking TFEB-mediated autophagy in rotenone-induced neurodegeneration.

Rotenone, a widely used pesticide, causes dopaminergic neurons loss and increase the risk of Parkinson's disease (PD). However, few studies link the role of PARP1 to neuroinflammatory response and autophagy dysfunction in rotenone-induced neurodegeneration. Here, we identified that PARP1 overactivation caused by rotenone led to autophagy dysfunction and NLRP3-mediated inflammation.

The combination of RNA-seq transcriptomics and data-independent acquisition proteomics reveals the mechanisms underlying enhanced salt tolerance by the gene in [L.] Merr.

[L.] Merr. is one of the three most economically important species due to its strong salt tolerance and wide application.

Process optimization to enhance utilization efficiency of precipitants for chloride removal from flue gas desulfurization wastewater via Friedel's salt precipitation.

The treatment cost for Cl removal by Friedel's salt precipitation depended significantly on utilization rate of the precipitant aluminate. In this study, effects of Ca/Al molar ratio, reaction time, temperature and Al/Cl molar ratio were investigated to maximize Al utilization rate for Cl removal from flue gas desulfurization wastewater. Batch results showed that the maximum Al utilization rate of 55.

Recovering chemical sludge from the zero liquid discharge system of flue gas desulfurization wastewater as flame retardants by a stepwise precipitation process.

In this study, a five-stage stepwise precipitation process, including pre-sedimentation, magnesium removal, gypsum precipitation, ettringite precipitation and calcium removal, was proposed as a softening pretreatment for zero liquid discharge system for flue gas desulfurization wastewater. Batch tests and long-term bench-scale experiment showed that magnesium, sulfate and calcium were efficiently removed with efficiencies all above 98.0%, leaving a clean effluent majorly containing NaCl and NaOH.

Partial nitrification performance and microbial community evolution in the membrane bioreactor for saline stream treatment.

Effects of salinity level and gradient on partial nitrification performance, sludge properties and microbial activities were investigated using partial nitrification membrane bioreactors (PN-MBRs). PN-MBRs obtained stable nitrite accumulation rate of 91.1% and ammonia removal of 64.

A two-stage desalination process for zero liquid discharge of flue gas desulfurization wastewater by chloride precipitation.

A two-stage desalination process was developed to achieve zero liquid discharge (ZLD) of flue gas desulfurization (FGD) wastewater by precipitating chloride as Friedel's salt. Influential factors for Friedel's salt precipitation, including dosage, reaction time, concentration of sulfate, were investigate by batch tests. Batch results showed that at calcium to aluminum molar ratio of 3.

[Prognostic Value of CD14HLA-DR Myeloid Derived Suppressor Cells in Diffuse Large B Cell Lymphoma].

Objective: To investigate the role of myeloid-derived suppressor cells (MDSC) in the prognosis of patients with diffuse large B cell lymphoma (DLBCL).

Methods: The peripheral blood of 52 DLBCL patients and 30 healthy volunteers was collected. The CD14HLA-DR was used as the immune marker for MDSC.

Hypoxia-responsive block copolymer radiosensitizers as anticancer drug nanocarriers for enhanced chemoradiotherapy of bulky solid tumors.

Radiosensitizers play an important role in the clinical radiotherapy of hypoxic solid tumors to improve therapeutic efficacy. However, the in vivo performance of clinically used small-molecule radiosensitizers is commonly compromised by low bioavailability in hypoxic tumor regions. Herein, amphiphilic block copolymer radiosensitizers are prepared from clinically approved poly(ethylene glycol)-block-poly(l-glutamic acid) (PEG-b-PLG) and metronidazole (MN) to obtain MN-grafted PEG-b-PLG (PEG-b-P(LG-g-MN)) via condensation reaction, which can self-assemble into core-shell micelles as nanoparticle-formulated radiosensitizers in aqueous solution.

A bilaminated decellularized scaffold for islet transplantation: Structure, properties and functions in diabetic mice.

Ectopic transplantation of islets provides a beta cell-replacement approach that may allow the recovery of physiological regulation of the blood sugar level in patients with Type I diabetes (T1D). In development of new extrahepatic islet transplantation protocols in support of the islet engraftment, it is pivotal to develop scaffold materials with multifaceted functions to provide beneficial microenvironment, mediate host response in favor of vascularization/islet integration and maintain long-term islet function at the transplantation site. In this study, a new composite bilaminar decellularized scaffold (CDS) was fabricated with differential structural, degradation and mechanical properties by the combination of a fast-degrading porous collagen matrix and a mechanically supportive porcine pericardium.

Facile Preparation and Radiotherapy Application of an Amphiphilic Block Copolymer Radiosensitizer.

Radiosensitizer plays an important role in the cancer radiotherapy for efficient killing of hypoxic cancer cells at a low radiation dose. However, the commercially available small molecular radiosensitizers show low efficiency due to poor bioavailability in tumor tissues. In this report, we develop a novel amphiphilic block copolymer radiosensitizer, metronidazole-conjugated poly(ethylene glycol)--poly(γ-propargyl-l-glutamate) (PEG--P(PLG--MN)), which can be self-assembled into core-shell micelles (MN-Micelle) with an optimal size of ∼60 nm in aqueous solution.

Effect of postprocedural full-dose infusion of bivalirudin on acute stent thrombosis in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: Outcomes in a large real-world population.

Aim: This study aimed to evaluate the effect of prolonged full-dose bivalirudin infusion in real-world population with ST-elevation myocardial infarction (STEMI).

Background: Subgroup data as well as meta-analysis from randomized clinical trials have shown the potency of postprocedural full-dose infusion (1.75 mg/kg/h) of bivalirudin on attenuating acute stent thrombosis (ST) after primary percutaneous coronary intervention (PCI).

The effect of sex counselling in the sexual activity of acute myocardial infarction patients after primary percutaneous coronary intervention.

Background: Primary percutaneous coronary intervention has improved the outcome of acute myocardial infarction (AMI) patients. Counsel-guided sex rehabilitation efficacy in acute myocardial infarction patients receiving percutaneous coronary intervention remains unknown.

Objective: The aim of the study was to study counsel-guided sex rehabilitation efficacy in AMI patients receiving percutaneous coronary intervention.

Trimetazidine Prevention of Contrast-Induced Nephropathy in Coronary Angiography.

Background: Contrast-induced nephropathy (CIN) after coronary angiography is frequently observed in patients with chronic renal insufficiency and no effective measures have been developed for prevention of CIN. There is evidence showing that trimetazidine (TMZ) has renoprotective effect on CIN. This study was to evaluate the role of TMZ in the prevention of CIN in renal dysfunction patients undergoing coronary angiography.

Correlation of serum alanine aminotransferase and aspartate aminotransferase with coronary heart disease.

Objective: This study aimed to explore the relationship between different risk factors (especially serum alanine aminotransferase [ALT] and aspartate aminotransferase [AST]) and coronary heart disease (CHD).

Methods: A total of 610 inpatients were recruited. Initial coronary angiography (CAG) was performed to evaluate the severity of coronary lesions.

One-step repair for cartilage defects in a rabbit model: a technique combining the perforated decalcified cortical-cancellous bone matrix scaffold with microfracture.

Background: Cartilage repair still presents a challenge to clinicians and researchers alike. A more effective, simpler procedure that can produce hyaline-like cartilage is needed for articular cartilage repair.

Hypothesis: A technique combining microfracture with a biomaterial scaffold of perforated decalcified cortical-cancellous bone matrix (DCCBM; composed of cortical and cancellous parts) would create a 1-step procedure for hyaline-like cartilage repair.

Caffeine does not enhance radiosensitivity of normal liver tissue in vivo.

The aim of this study was to determine whether caffeine enhanced radiosensitivity of normal liver tissue in a rat radiation-induced liver disease model. Buffalo rat McA-RH7777 hepatocellular cancer cells and BRL3A normal liver cells were irradiated, and cell cycle distribution and apoptosis rates were analyzed. A rat model of radiation-induced liver disease was established, rats were randomized into four groups: control; caffeine alone; irradiation (IR) alone; and caffeine plus IR (Caff + IR) group.

Radiation-induced liver fibrosis is mitigated by gene therapy inhibiting transforming growth factor-β signaling in the rat.

Purpose: We determined whether anti-transforming growth factor-β (TGF-β) intervention could halt the progression of established radiation-induced liver fibrosis (RILF).

Methods And Materials: A replication-defective adenoviral vector expressing the extracellular portion of human TβRII and the Fc portion of immunoglobulin G fusion protein (AdTβRIIFc) was produced. The entire rat liver was exposed to 30 Gy irradiation to generate a RILF model (RILFM).

Caffeine enhances radiosensitization to orthotopic transplant LM3 hepatocellular carcinoma in vivo.

The aim of this study was to determine whether caffeine enhanced radiosensitization in an orthotopic transplant of LM3 human hepatocellular cancer in nude mice. LM3 hepatocellular carcinoma cells were infected with red fluorescent protein and irradiated, and cell cycle distribution and survival fraction were detected. A nude mouse model of orthotopic transplant of red fluorescent protein-expressing LM3 hepatocellular cancer was established.

Regenerative capacity of normal and irradiated liver following partial hepatectomy in rats.

Purpose: To investigate the regenerative capacity and proliferation related to cell cycle modulators in irradiated livers after partial hepatectomy (PH) in rats.

Methods And Materials: Two experimental groups were given a single dose of either 4-Gy or 8-Gy photon radiation to the whole liver following PH. The control group underwent only PH, without irradiation.