Systolic blood pressure modifies the effect of endovascular thrombectomy in acute ischemic stroke: a mediation analysis.

Background: Systolic blood pressure (BP) is a key factor in the outcomes of patients with acute ischemic stroke (AIS) receiving endovascular thrombectomy (EVT). However, the factors that mediate the association between BP and clinical outcome are unclear.

Methods: Consecutive patients with AIS in the anterior circulation underwent continuous blood pressure monitoring for 24 hours.

An interdisciplinary perspective of the built-environment microbiome.

The built environment provides an excellent setting for interdisciplinary research on the dynamics of microbial communities. The system is simplified compared to many natural settings, and to some extent the entire environment can be manipulated, from architectural design to materials use, air flow, human traffic, and capacity to disrupt microbial communities through cleaning. Here we provide an overview of the ecology of the microbiome in the built environment.

LncRNA HOXB3OS improves high glucose-mediated podocyte damage and progression of diabetic kidney disease through enhancing SIRT1 mRNA stability.

High glucose (HG)-mediated podocyte damage can be ameliorated by lncRNA HOXB3OS, and exosomes derived from adipose-derived mesenchymal stem cells (ADSCs-Exo) can ameliorate the progression of diabetic kidney disease (DKD) dependening on RNA. To investigate the mechanism by which HOXB3OS improves podocyte injury and the effects of engineered ADSCs-Exo with a high abundance of HOXB3OS on DKD progression, MPC5 cells stimulated with HG and db/db mice were used to develop a podocyte injury model and type II DKD mouse model, respectively. HOXB3OS expression and mRNA level of SIRT1 were detected by qRT-PCR.

Cropformer: An Interpretable Deep Learning Framework for Crop Genome Prediction.

Machine learning and deep learning have been employed in genomic selection (GS) to expedite the identification of superior genotypes and accelerate breeding cycles. However, a significant challenge for current data-driven deep learning models in GS is their low robustness and interpretability. To address this challenge, we developed Cropformer, a deep learning framework for predicting crop phenotypes and exploring downstream tasks.

Research on Environmental Risk Monitoring and Advance Warning Technologies of Power Transmission and Distribution Projects Construction Phase.

The threat power transmission and distribution projects pose to the ecological environment has been widely discussed by researchers. The scarcity of early environmental monitoring and supervision technologies, particularly the lack of effective real-time monitoring mechanisms and feedback systems, has hindered the timely quantitative identification of potential early-stage environmental risks. This study aims to comprehensively review the literature and analyze the research context and shortcomings of the advance warning technologies of power transmission and distribution projects construction period using the integrated space-sky-ground system approach.

Investigation of Mechanical Properties and Oil Resistance of Hydrogenated-Butadiene-Acrylonitrile-Rubber-Based Composites Across Various Temperatures.

The influence of molecular structure (acrylonitrile content) and formulation (carbon black and plasticizer dosage) on the rheological and mechanical properties of HNBR composites was systematically studied, with further discussion on ozone resistance and swelling behavior in transformer oil. The results demonstrated that the curing characteristics and rheological behavior of HNBR composites are closely linked to acrylonitrile content, carbon black, and plasticizer levels. Plasticizers significantly reduced the degree of crosslinking and the Payne effect, while fillers had the opposite impact.

A bibliometric analysis of root canal irrigation: From laboratory to clinical practice.

The study aims to conduct a bibliometric analysis on root canal irrigation to elucidate the development of this domain and pose the future research trends. Of 6722 articles retrieved from Clarivate Analytics' Web of Science Core Collection and PubMed, 6650 publications were included for bibliometric analysis. Irrigation field had received emerging attention for the last half century, peaking at 399 in 2022.

Chinese guidelines for minimally invasive donor hepatectomy in living donor liver transplantation (2024 edition).

Background: Minimally invasive surgeries are increasingly central to modern medicine, particularly in liver transplantation. These techniques, which offer reduced trauma, precise operations, minimal bleeding, and swift recovery, are, however, unevenly adopted across China. Only a limited number of centers routinely perform minimally invasive donor hepatectomies, indicating a significant imbalance in the development and application of these advanced procedures.

Enhancing rejection of short-chain per- and polyfluoroalkyl substances by tailoring the surface charge of nanofiltration membranes.

Nanofiltration (NF) effectively removes per- and polyfluoroalkyl substances (PFAS) from water but struggles with short-chain PFAS (i.e., those containing less than 6 perfluorinated carbons) due to size exclusion inefficiency.

Solids retention time modulates nutrient removal in pilot-scale anaerobic-aerobic-anoxic process: Carbon allocation patterns and microbial insights.

Anaerobic-aerobic-anoxic (AOA) process is a promising configuration to retrofit current wastewater treatment plants with intensified carbon utilization and nutrient removal, but lacks process optimization for scaling-up in real wastewater scenarios. Solids retention time (SRT) is a fundamental parameter of activated sludge process, but its roles in the AOA process remain vague. Here, we established a pilot-scale AOA process at different SRTs (10, 20, 30 d) to investigate the comprehensive responses and potential mechanisms.

An enzyme-mimicking reactive oxygen species scavenger targeting oxidative stress-inflammation cycle ameliorates IR-AKI by inhibiting pyruvate dehydrogenase kinase 4.

: Ischemia-reperfusion-induced acute kidney injury (IR-AKI), characterized by the abrupt decline in renal function, is distinguished by the intricate interplay between oxidative stress and inflammation. In this study, a reactive oxygen species (ROS) scavenger-CF@PDA was developed to effectively target antioxidant and anti-inflammatory pathways to disrupt the oxidative stress-inflammation cycle in IR-AKI. : UV-vis absorption spectra, FTIR spectra, and TEM were employed to determine the successful construction of CF@P.

Denitrifying anaerobic methane oxidation activity and microbial mechanisms in Riparian zone soils of the Yulin River, a tributary of the Three Gorges Reservoir.

Riparian zones are recognized as major sources of greenhouse gas emissions, particularly methane (CH). Denitrifying anaerobic methane oxidation (DAMO) has garnered growing attention due to its significant contribution to mitigating CH emissions in wetland environments. Nonetheless, the specific role and microbial mechanisms of DAMO in controlling CH release within riparian zones are still not well comprehended.

The near-complete genome assembly of hexaploid wild oat reveals its genome evolution and divergence with cultivated oats.

Avena sterilis, the ancestral species of cultivated oats, is a valuable genetic resource for oat improvement. Here we generated a near-complete 10.99 Gb A.

Assessing knowledge anxiety in researchers: a comprehensive measurement scale.

Background: The rapid pace of knowledge production has introduced a phenomenon termed "knowledge anxiety", a psychological state where researchers feel inadequate in keeping up with emerging information. This state can negatively affect productivity and mental well-being, yet there is no comprehensive tool to measure knowledge anxiety across different research domains.

Methods: We employed a mixed-methods approach to develop a multidimensional scale for assessing knowledge anxiety.

Association between uric acid to high-density lipoprotein cholesterol ratio and chronic kidney disease among Chinese middle-aged and older adults with abnormal glucose metabolism: a nationwide cohort study.

Background: Previous research has demonstrated a correlation between uric acid to high-density lipoprotein cholesterol ratio (UHR) and chronic kidney disease (CKD), yet the evidence remains unclear in individuals with abnormal glucose metabolism. The objective of this research was to investigate the correlation between UHR and the occurrence of CKD, as well as the rapid kidney function decline among individuals aged over 45 years with abnormal glucose metabolism, using data from the China Health and Retirement Longitudinal Study (CHARLS).

Methods: This study employed K-means clustering to categorize individuals based on UHR control levels into four classes.

Taxonomic insights and new geographic records of A. Evans (Metzgeriales, Metzgeriaceae): A re-assessment based on discoveries in Shennongjia National Park, China.

Background: , a genus established in 1818, has been the subject of various taxonomic studies, with revisions leading to the recognition of several genera within the Metzgeriaceae family. Recent research indicates that constitutes over 98% of the family's species, with broad global distribution.

New Information: During a bryophyte survey in Shennongjia National Park, A.

Urine PLA2R Antibody Detection in Hazard Stratification of PLA2R-Associated Membranous Nephropathy.

Context.—: M-type phospholipase A2 receptor (PLA2R) is the major autoantigen of membranous nephropathy (MN). As the specific antibodies of MN, the correlation between serum PLA2R antibody (sPLA2R-Ab) levels and PLA2R-associated MN (PMN) risk stratification is still controversial.

Programmable nonlinear optical neuromorphic computing with bare 2D material MoS.

Nonlinear optical responses in two-dimensional (2D) materials can build free-space optical neuromorphic computing systems. Ensuring the high performance and the tunability of the system is essential to encode diverse functions. However, common strategies, including the integration of external electrode arrays or photonic structures with 2D materials, and barely patterned 2D materials, exhibit a contradiction between performance and tunability.

Hepatic arterial infusion chemotherapy (HAIC) combined with Tislelizumab and Lenvatinib for unresectable hepatocellular carcinoma: a retrospective single-arm study.

Purpose: We aimed to explore the curative effects of hepatic arterial infusion chemotherapy (HAIC) combined with Tislelizumab and Lenvatinib on unresectable hepatocellular carcinoma (HCC).

Patients And Methods: From September 2021 to September 2023, 42 patients with unresectable HCC who were treated in the First Affiliated Hospital of Chongqing Medical University were enrolled in this retrospective single-arm study. They received HAIC combined with Tislelizumab and lenvatinib.

The multifaceted nature of diabetic erectile dysfunction: uncovering the intricate mechanisms and treatment strategies.

Background: One of the most common complications of diabetes mellitus is diabetic erectile dysfunction (DMED), a condition that has grown more common in recent years and has a significant impact on patients' daily lives. The complicated pathophysiological changes of DMED, involving vascular, neurological, muscular, and endocrine variables, have not been well addressed by any one treatment technique, and no widely approved treatment strategy has been developed.

Aim: The objective of this study was to thoroughly examine the complex nature of the pathogenic mechanism of DMED and discover new therapeutic approaches that could improve DMED symptoms.

Two machine learning-derived nomogram for predicting the occurrence and severity of acute graft-versus-host disease: a retrospective study based on serum biomarkers.

Background: Acute graft-versus-host disease (aGVHD) is a common complication after allogeneic hematopoietic cell transplantation (allo-HSCT), with high morbidity and mortality. Although glucocorticoids are the standard treatment, only half of patients achieve complete remission. Thus, there is an urgent need to screen biomarkers for the diagnosis of aGVHD to assist in the identification of individuals at risk of aGVHD.