Publications by authors named "Qiang Chao"
J Nanobiotechnology
June 2023
Article Synopsis
- Congenital disorders of glycosylation (CDGs) are complex genetic diseases linked to issues in glycan production, making diagnosis difficult due to their varied symptoms.
- Recent research focused on developing a liposome-based vaccine that includes specific biomarkers for ALG1-CDG and PMM2-CDG, enhancing immune responses and promoting the production of high-affinity IgG antibodies.
- The study found that the new vaccine platform effectively generated strong IgG responses targeted at CDG biomarkers, indicating potential for rapid diagnostic methods for these disorders.
Article Synopsis
- - Asparagine (N)-linked glycosylation is crucial for how proteins operate in the body, influencing their folding, stability, and movement between cells.
- - The chemo-enzymatic method offers a promising way to produce structurally uniform N-glycans efficiently compared to traditional chemical synthesis, and this review highlights recent advancements in this area.
- - The article addresses challenges and opportunities in the chemo-enzymatic synthesis of N-glycans, while also discussing practical applications like automated devices and the creation of consistent glycoproteins.
