The first report of subgenus Blacus Nees, 1819 (Hymenoptera, Braconidae, Brachistinae) from China.

The subgenus Blacus Nees, 1819 (Hymenoptera, Braconidae, Brachistinae, Blacini, Blacus) is reported from China for the first time. Eight new species, B. (B.

Risk factors of disease activity and renal damage in patients with systemic lupus erythematosus.

Purpose: To evaluate the clinical features of patients with Systemic Lupus Erythematosus (SLE) and explore the risk factors of disease activity and renal damage.

Methods: A retrospective study involving 194 patients were performed. Patients were divided into lupus nephritis (LN) group (63.

Review of the subgenus Tarpheion of the genus Blacus Nees (Hymenoptera, Braconidae, Brachistinae) from China, with description of nine new species and eight new records.

An updated key to the currently known species of the subgenus Tarpheion van Achterberg, 1976 (Hymenoptera, Braconidae, Blacus) in China is provided. Nine new species are proposed, B. (T.

Scavenger Receptor Class B Type I Deficiency Induces Iron Overload and Ferroptosis in Renal Tubular Epithelial Cells Hypoxia-Inducible Factor-1α/Transferrin Receptor 1 Signaling Pathway.

Scavenger receptor class B type I (SRBI) promotes cell cholesterol efflux and the clearance of plasma cholesterol. Thus, deficiency causes abnormal cholesterol metabolism and hyperlipidemia. Studies have suggested that ferroptosis is involved in lipotoxicity; however, whether deficiency could induce ferroptosis remains to be investigated.

The discovery of the subgenus Contochorus van Achterberg, 1976 (Hymenoptera, Braconidae, Brachistinae, Blacini, Blacus) in China.

The subgenus Contochorus van Achterberg, 1976 (Hymenoptera, Braconidae, Blacus) is newly recorded from China. Two new species are proposed, B. (C).

The discovery of the subgenus Hysterobolus Viereck, 1913 (Hymenoptera, Braconidae, Brachistinae, Blacini, Blacus) in China, with description of nine new species.

The subgenus Hysterobolus Viereck, 1913 (Hymenoptera, Braconidae, Blacus) is newly recorded from China. Nine new species are proposed, B. (H.

Empagliflozin attenuates the renal tubular ferroptosis in diabetic kidney disease through AMPK/NRF2 pathway.

Renal tubular damage plays a key role in the pathogenesis of diabetic kidney disease (DKD), and one of the main pathological process associated with DKD in diabetic mice is the ferroptosis, a novel form of cell death caused by iron-dependent lipid peroxidation. Several researches suggested that empagliflozin may treat renal injury, but its effects on diabetic-related ferroptosis and underlying mechanisms were not fully elucidated. In this study, the influence of empagliflozin on renal injury was evaluated in vivo and in vitro in a mouse model and in high-glucose (HG) or Erastin-stimulated renal HK-2 cell line, respectively.

Paraoxonase 1 Ameliorates Renal Lipotoxicity by Activating Lipophagy and Inhibiting Pyroptosis.

Several studies in recent years have shown that lipid overload causes lipotoxic damage to the kidney, and oxidative stress, inflammation, and autophagic arrest are all important mechanisms of renal lipotoxicity. However, effective measures with therapeutic effects on renal lipotoxicity are limited. The present study indicated the protective effect of the paraoxonase 1 (PON1) against renal lipotoxicity in high-fat diet-fed scavenger receptor class B type I-deficient (SR-BI) mice.