Publications by authors named "QianQian Lu"
Thiacloprid (THI) is a neonicotinoid insecticide, and its residues pose potential risks to the ecological environment and human health. In this study, computer simulation technology was applied to analyze THI haptens to ensure the similarity in spatial structure, charge properties, and potential distribution. And anti-THI monoclonal antibodies insensitive to matrix effects were prepared using sample extraction solution to simulate the matrix environment, with the half-maximal inhibitory concentration of 0.
View Article and Find Full Text PDFMutations in dental hypophosphatasia (HPP) have been reported less than those in other types of HPP because the symptoms are mild or the dental lesions are only partial manifestations of other types of HPP. In this case, we observe the clinical manifestation of dental hypoalkaline phosphatase by analyzing the genetic mutation and biochemical parameters in child. The clinical data of the child with odonto HPP were collected and analyzed.
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- Microemulsion systems can create nano/microstructures, but there's a lack of understanding in controlling how these structures form at the interface.
- The researchers propose a new method called nucleation-inhibited microemulsion interfacial assembly to create polydopamine microvesicles (PDA MVs), which resemble cell shapes and are about 1 µm in size.
- When modified with antibodies, these PDA MVs significantly boost T-cell activation compared to solid nanoparticles, demonstrating their potential as effective artificial antigen-presenting cells.
Article Synopsis
- The paper discusses a new approach to creating 1D branched magnetic nanochains made from magnetite and mesoporous silica, utilizing both physical and chemical processes for assembly.
- By combining magnetic-field-induced assembly and isotropic/anisotropic methods, the researchers achieved nanochains that are 2-3 µm long, composed of 150 nm diameter spheres with 300 nm branches.
- These nanochains demonstrate strong bacterial adhesion and can inhibit bacterial growth by over 60% at low concentrations, providing insights into micro-nanoscale assembly and potential applications in complex material designs.
Amitraz (AMT) is a broad-spectrum formamidine insecticide and acaricide. In this study, we produced an anti-AMT monoclonal antibody (mAb) with high performance. The half-maximal inhibitory concentration of the anti-AMT mAb was 4.
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- Histone modifications like H2B ubiquitination (H2Bub) and H3K4 trimethylation (H3K4me3) are linked to activating gene transcription, but their role in plant flowering remains unclear.
- This study identifies how H2Bub and H3K4me3 deposition interact with the factor VIP2 to regulate the transcription of the FLOWERING LOCUS C (FLC) gene, affecting flowering time in Arabidopsis.
- The findings show that proteins HUB1/2 and ATX1 are crucial for recruiting VIP2 to FLC, influencing gene expression and ultimately the timing of flowering in plants.
HMGA1 regulates the mitochondrial apoptosis pathway in sepsis-induced cardiomyopathy.
Cell Biochem Biophys
June 2024
Article Synopsis
- High mobility group protein AT-hook 1 (HMGA1) is a transcription factor that has been linked to cardiac remodeling but its specific role in cardiovascular diseases like sepsis-induced cardiomyopathy is not well understood.
- The study explored how HMGA1 influences lipopolysaccharide-induced cardiomyopathy in mice, using both overexpression and knockdown methods in cardiomyocytes.
- Results showed that overexpressing HMGA1 increased inflammation and apoptosis in cardiomyocytes after lipopolysaccharide treatment, while knocking it down reduced these harmful effects, indicating that HMGA1 may worsen cardiac damage through a mitochondria-dependent apoptotic pathway.
Article Synopsis
- This study compares two surgical techniques for treating Stanford type B aortic dissections with poor proximal landing zones: 3D printing-assisted extracorporeal pre-fenestration and Castor integrated branch stent.
- In a retrospective analysis of 84 patients, both methods had a 100% surgical success rate; however, the 3D printing group had longer surgery times.
- The 3D printing approach also showed lower rates of postoperative complications, like cerebral infarction, compared to the Castor method, indicating it may be a safer option despite the longer operative time.
Objective: To explore the predictive value of interleukin-6 (IL-6) combined with human neutrophil lipocalin (HNL) of stroke-associated pneumonia (SAP) in patients who were diagnosed with acute ischemic stroke (AIS).
Methods: 108patients were divided into two groups: pneumonia group (52 cases) and non-pneumonia group (56 cases), according to whether the patients developed SAP within 7 days of admission. General information was compared between the two groups, like age, gender, history of hypertension, diabetes mellitus, cardiovascular disease, dysphagia, smoking and alcoholhistory.
Article Synopsis
- The study used density functional theory to investigate how cycloadditions of tetrachloro-o-benzoquinone and 6,6-dimethylfulvene occur at the molecular level.
- It identified that primary interactions help stabilize certain transition states, specifically in the endo reaction pathways.
- The results showed that these transition states lead to various types of adducts that can transform into each other through specific shift reactions, and the effect of substituents on the selectivity of the reactions was also looked into.
Article Synopsis
- The Lautens group discovered a palladium-catalyzed three-component domino reaction that effectively synthesizes indenes from -iodostyrene, ONBD, and phenylboronic acid.
- Density functional theory (DFT) calculations were used to investigate the reaction mechanism, revealing that two potential pathways are competitive, with the alkene-insertion-first mechanism being slightly more favorable.
- Further studies on the substituents of ONBD highlighted how noncovalent interactions and electronic effects influence the rate-determining retro-Diels-Alder step, contributing to the understanding of this catalytic process for future applications.
Article Synopsis
- Flupyradifurone (FPF) is a neonicotinoid insecticide that targets various agricultural pests effectively.
- Researchers developed a specific immunochromatographic assay using an anti-FPF monoclonal antibody to detect FPF residues in grapes, blueberries, and tomatoes, with varying cut-off values.
- The assay demonstrated high sensitivity and recovery rates, proving to be a reliable method for quick screening of FPF residues in these fruits.
Article Synopsis
- The study compared two techniques for repairing the Left Subclavian Artery in patients with Stanford Type B Aortic Dissection, focusing on outcomes of 3D-printing-assisted extracorporeal fenestration versus conventional extracorporeal fenestration.
- A total of 57 patients were reviewed, highlighting key metrics such as operative time, complication rates, and aortic remodeling, with findings indicating that the 3D-printing technique had a shorter operative time and lower endoleak risk.
- Both methods were deemed safe and effective, with 3D-printing providing advantages in certain outcomes, while the conventional method showed benefits in stent modification time.
Article Synopsis
- Ferroptosis is a regulated cell death mechanism linked to treatment resistance and poor outcomes in hepatocellular carcinoma (HCC), emphasizing the need to understand its biological processes.
- The study focuses on the circular RNA hsa_circ_0128505, which enhances ferroptosis in HCC cells under treatment with lenvatinib by modulating ER-phagy through reactive oxygen species (ROS) and malondialdehyde (MDA).
- It identifies poly (A) binding protein cytoplasmic 4 (PABPC4) as a key protein in the process, acting as an antagonist to nonsense-mediated mRNA decay (NMD), and reveals its interaction with the circRNA as a possible novel
In recent years, tremendous progress has been made in the development of nanomedicines for advanced therapeutics, yet their unsatisfactory targeting ability hinders the further application of nanomedicines. Nanomaterials undergo a series of processes, from intravenous injection to precise delivery at target sites. Each process faces different or even contradictory requirements for nanoparticles to pass through biological barriers.
View Article and Find Full Text PDFThe ring-closing metathesis reaction of diene plays an important role in the construction of cyclic compounds. In this research, density functional theory (DFT) calculations were conducted to elucidate the mechanisms and origins of the selectivity of ring-closing metathesis and homometathesis. The computational results suggest that the selectivity is determined by the substrate conformation.
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- * A hybrid Machine Learning model combining Random Forest and Logistic Regression was developed to evaluate I&E quality in 25 leading higher education institutions across China, focusing on constructing a quality index and ranking educational indicators.
- * Findings show universities are successfully integrating entrepreneurship into their curricula, which improves curriculum development rankings and helps identify growth areas to enhance economic development and I&E skills among students.
Article Synopsis
- * An immunochromatographic assay was created to screen for CDM in cucumbers and tomatoes, achieving high sensitivity and specific limits of detection.
- * The assay demonstrated excellent recovery rates, confirming its accuracy and efficiency for detecting CDM residues in these crops.
Article Synopsis
- The study focused on understanding genetic traits of sorghum-sudangrass hybrids by obtaining an F2 population through controlled breeding methods to analyze their heterosis and essential yield characteristics.
- Quantitative trait locus (QTL) mapping was performed on various plant traits across different environments, identifying 55 QTLs that explain significant phenotypic variation important for yield improvement.
- The research highlighted 17 high-frequency yield-related QTLs, identifying candidate genes for breeding efforts, and suggested that certain QTLs may enhance the understanding of genetic mechanisms in these hybrids.
The synergistic activity of SBC3 in combination with Ebselen against infection.
Front Pharmacol
December 2022
Article Synopsis
- The text discusses a study on a major clinical isolate in China that causes over 160 million dysentery cases and one million deaths annually.
- It highlights the effectiveness of a drug combination involving SBC3 and Ebselen, which shows strong antibacterial properties without harming mammalian cells.
- The combo works by inhibiting key bacterial processes, leading to cell death, and proves effective against several hard-to-treat Gram-negative bacteria.
Impacts of a bacterial algicide on metabolic pathways in Chlorella vulgaris.
Ecotoxicol Environ Saf
January 2023
Article Synopsis
- * Atrazine-desethyl (AD), identified as a potent algicide from strain M1, shows significant algicidal effects and induces damage to Chlorella vulgaris cells, impacting morphology, chlorophyll production, gene expression, and causing oxidative stress.
- * The study reveals that AD exposure alters algal metabolism, reducing levels of amino acids and affecting pathways related to osmotic pressure and oxidative stress, suggesting a complex defensive response from Chlorella
Clinicopathological and prognostic significance of COX-2 in glioma patients: a meta-analysis.
Arq Neuropsiquiatr
December 2022
Article Synopsis
- Recent studies have identified cyclooxygenase-2 (COX-2) as a marker related to cancer stem cells in gliomas, but its significance in patient prognosis is still debated.
- A meta-analysis of 11 studies with 641 patients revealed that high COX-2 expression correlates with poorer overall survival rates in glioma patients, with consistent results across different ethnic groups.
- The findings suggest that COX-2 could serve as an important pathological and prognostic biomarker in clinical settings.
Article Synopsis
- Selenium shows promising antitumor effects but is less effective in the low-oxygen environments of solid tumors, prompting researchers to explore combining selenium with oxygen therapy to enhance its efficacy.
- In experiments with tumor-bearing mice, two selenium compounds significantly reduced tumor growth, and when paired with oxygen therapy, they decreased tumor volume by approximately 50%.
- The study also revealed that oxygen levels influence how selenium affects cancer cells, with hyperoxia enhancing apoptosis (cell death) and altering key cellular signaling pathways, offering new strategies for treating hypoxic tumors.
Article Synopsis
- The study created an ultra-high-density genetic linkage map for the sorghum-sudangrass hybrid using 150 F2 individuals and high-throughput whole genome resequencing.
- Over 5,656 high-quality single nucleotide polymorphism markers were identified, leading to a map that covers about 2,192.84 cM with an average marker interval of 0.39 cM.
- This is the first genetic linkage map of its kind for this hybrid, providing useful insights for future research on species evolution, quantitative trait loci mapping, and marker-assisted breeding.
Article Synopsis
- The study investigates the impact of Akkermansia muciniphila (A. muciniphila), a promising probiotic, on cadmium-induced intestinal damage in mice.
- Mice treated with A. muciniphila exhibited less intestinal damage, improved body weight, longer colon length, reduced inflammation, and increased levels of glutathione and goblet cells.
- The research suggests that A. muciniphila enhances melatonin production, which helps mitigate cadmium toxicity by scavenging harmful reactive oxygen species and promoting goblet cell growth.