Publications by authors named "Qian-ming Xia"

Background: Acute ischemic stroke (AIS) is the major type of stroke, which highly risks human health and life quality. Governor vessel acupuncture (GV Ac) is one specific acupoint selection treatment. This study aimed to systematically evaluate the clinical value of GV Ac in AIS patients.

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Objective: To investigate the efficacy and safety of domestic tiotropium inhalation capsule in patients with chronic obstructive pulmonary disease (COPD) with multi-center randomized clinical trial.

Methods: Patients with stable slight to moderate COPD were randomized into trial group (n=109) with tiotropium 18 pg Qd or control group (n =111) with ipratropium 40 µg Qid for a treatment of four weeks. The spirometry and scoring questionaire were recorded at different visits during the treatment.

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Levofloxacin (LVFX), a fluoroquinolone agent, has a broad spectrum that covers Gram-positive and -negative bacteria and atypical pathogens. It demonstrates good clinical efficacy in the treatment of various infections, including lower respiratory tract infections (LRTIs) and urinary tract infections (UTIs). To evaluate the efficacy and safety of oral LVFX 500 mg once daily, a large open-label clinical trial was conducted in 1266 patients (899 with LRTIs and 367 with UTIs) at 32 centers in China.

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Article Synopsis
  • - The study investigated how the antibiotic levofloxacin (LVFX) works in Chinese patients with respiratory infections, aiming to establish 500 mg once daily as the best treatment plan through pharmacokinetic-pharmacodynamic (PK-PD) analysis.
  • - Researchers analyzed 1052 plasma samples from 164 patients and identified that kidney function (creatinine clearance) and body weight significantly impacted how LVFX was processed in the body.
  • - Results suggested that patients with various levels of kidney function (especially those with lower kidney function) may require dosage adjustments, but no relationship was found between drug parameters and side effects.
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