Publications by authors named "Qian-Yu Gao"
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is significantly upregulated in glioblastoma (GBM) and plays a crucial role in cell apoptosis and drug resistance. Micheliolide (MCL) is a natural product with a variety of antitumour activities, and the fumarate salt form of dimethylamino MCL (DMAMCL; commercial name ACT001) has been tested in clinical trials for recurrent GBM; this compound suppresses the proliferation of GBM cells by rewiring aerobic glycolysis. Herein, we demonstrated that MCL directly targets GAPDH through covalent binding to the cysteine 247 (Cys247) residue.
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- Artificial solid electrolyte interphase (SEI) layers protect lithium metal anodes from corrosion, and this study develops a new SEI using dense LiLaZrTaO (LLZTO) nanoparticles mixed with polymerized rubber.
- The LLZTO-based SEI film enhances lithium deposition uniformity and speeds up electrochemical reactions due to its high lithium conductivity and mechanical strength.
- Results show that Li anodes with the LLZTO SEI maintain stable performance with low overpotential over long cycles, suggesting this approach could lead to better lithium battery designs.
[Authentication of Age of Bloodstains Using UV Visible Reflection Spectrum].
Guang Pu Xue Yu Guang Pu Fen Xi
August 2015
The age of bloodstains is tightly related to the time elapsed since the crime was committed. The inference of the time that the crime was committed is of great significance to solve the case, and it was also a difficult problem in judicial authentication. Therefore, establishing a method of rapid determination of bleeding time is very necessary.
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