Publications by authors named "Qian-Tong Dong"
Article Synopsis
- The study compares the newly introduced AWGC criteria for cachexia and GLIM criteria for malnutrition in gastric cancer patients who had radical gastrectomy, aiming to see which diagnosis better predicts patient outcomes.
- Out of 1420 patients, those diagnosed with either AWGC-cachexia or GLIM-malnutrition, or both, were found to have a higher risk of postoperative complications and lower overall survival rates.
- Both diagnosis criteria proved to be useful independently, with patients who had both conditions facing the worst prognosis, highlighting their value in preoperative nutritional assessments.
Article Synopsis
- Cachexia is common in cancer patients, but existing diagnostic criteria may not apply well to Asian populations, prompting this study to compare AWGC criteria with Fearon's criteria.
- The study analyzed data from 1330 patients who underwent radical gastrectomy, finding that those diagnosed with AWGC-cachexia had distinct characteristics and higher risks for complications and mortality compared to those diagnosed with Fearon’s criteria.
- Results suggest that AWGC criteria are more effective for diagnosing cancer cachexia in Asians and offer improved prognostic insights than Fearon's criteria.
Background: Preoperative albumin-bilirubin (ALBI) grade has been proposed and applied in recent years to evaluate the prognosis of liver cancer, but its role in gastric cancer (GC) is still unclear. This research aimed to examine the prognostic value of ALBI grade after gastrectomy among patients with GC complicated with metabolic syndrome (MetS).
Methods: There were 628 patients who received radical resection for GC.
Background: Sarcopenia, overweight and obesity are all dynamic changes in body composition, which may have a negative effect on the prognosis for patients with colorectal cancer. The aim of this study was to investigate the predictive role of sarcopenia on overweight or obese patients with colorectal cancer.
Methods: We conducted an observative study on the population of overweight or obese patients with colorectal cancer who underwent curative surgeries in two centers between 2015 and 2021.
Article Synopsis
- * Results indicate that patients who underwent laparoscopic surgery experienced fewer complications, shorter hospital stays, and improved overall and disease-free survival rates.
- * Key risk factors for complications and survival include hypoalbuminemia, older age, and TNM stage, with laparoscopic surgery being a significant protective factor against adverse outcomes.
Background: Malnutrition and sarcopenia are common in elderly gastric cancer patients, which are also interrelated and affect each other. We aimed to determine the characteristics of coexistence of malnutrition and sarcopenia in the elderly gastric cancer patients and investigate the predictive roles of malnutrition and sarcopenia on clinical outcomes.
Methods: Between 2014 and 2019, a total of 742 elderly gastric cancer patients were enrolled.
Purpose: Patients with gastric cancer after gastrectomy often suffer from a decline in their quality of life (QoL), but the relationship between body composition (BC) and physical function on QoL has rarely been studied. This study aims to evaluate and determine the changes in QoL after gastrectomy and the impact of BC and physical function on QoL.
Methods: A total of 311 gastric cancer patients completed EORTC QLQ-C30 and EORTC QLQ-STO22 questionnaires before and 1, 3, 6 months post-surgery.
Background: Malnutrition is common in colorectal cancer patients. Malnutrition is recognized as a risk factor for adverse postoperative outcomes, yet there are no consistent diagnostic criteria for it. Thus, the Global Leadership Initiative on Malnutrition published new universal criteria.
View Article and Find Full Text PDFBackground: Sarcopenia and cachexia are two predictors of adverse clinical outcomes, but they are partly overlapping. We aimed to compare the characteristics and prognostic value of cachexia and sarcopenia in patients after gastrectomy.
Methods: From 2014 to 2019, a total of 1215 gastric cancer patients were enrolled.
[Multiple Gastrointestinal Stromal Tumor with Neurofibromatosis Type Ⅰ:Report of One Case].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
October 2021
Article Synopsis
- Gastrointestinal stromal tumors (GISTs) are rare, especially when occurring in the stomach, duodenum, and rectum, and even more uncommon in patients with neurofibromatosis type I (NF-Ⅰ).
- A patient with a family history of NF-Ⅰ presented with several symptoms, including chest tightness and black stools, leading to hospitalization and further examination.
- Enhanced CT scans revealed multiple tumors in the abdomen, which were ultimately confirmed as wild-type GISTs through surgical pathology and genetic testing, with the patient experiencing a good recovery nearly a year post-operation.
Background: Sarcopenia is a nutrition-related disease and has a profound effect on the long-term overall survival (OS) of patients with gastric cancer. Its diagnostic criterion is critical to clinical diagnosis and treatment. However, previous research reported widely differing sarcopenia prevalence due to different criteria.
View Article and Find Full Text PDFObjective: The present study aims to determine the correlations between Global Leadership Initiative in Malnutrition (GLIM)-defined malnutrition and body composition and functional parameters, and to comprehensively analyze the predictive value of GLIM-defined malnutrition for postoperative outcomes in the context of detailed measurement of body composition and functional parameters in elderly patients who underwent radical gastrectomy for gastric cancer.
Methods: Elderly patients (aged ≥65 years) who underwent radical gastrectomy for gastric cancer from August 2014 to June 2019 were included. Malnutrition was diagnosed using the GLIM criteria.
Objectives: We investigated whether measurement of muscle quantity/quality has additional predictive value for postoperative complications and long-term survival after gastrectomy for gastric cancer in patients with probable sarcopenia, as defined by the new European Working Group on Sarcopenia in Older People 2 consensus.
Methods: We conducted a prospective study of patients who underwent a radical gastrectomy for gastric cancer between August 2014 and June 2019. Muscle strength was measured using a handgrip dynamometer.
Background: The present study aims to investigate the prognostic value of Global Leadership Initiative in Malnutrition (GLIM)-defined malnutrition in overweight patients who underwent gastrectomy for gastric cancer, and to explore whether the addition of muscle quality, strength and gait speed could improve the predictive power for postoperative outcomes.
Methods: Overweight patients (body mass index (BMI) ≥23 kg/m) who underwent radical gastrectomy for gastric cancer were included in this study. Malnutrition was diagnosed using the two-step approach following the GLIM criteria.
Background: The skeletal muscle mass index (SMI) and skeletal muscle radiodensity (SMD) are important components of sarcopenia and malnutrition. However, their assessment requires additional resources in cancer patients, which is inconvenient for the early detection of sarcopenia and malnutrition.
Objectives: This study aimed to develop and validate nomograms for the prediction of low muscle mass and muscle radiodensity and to examine the application value of the nomograms in the diagnoses of sarcopenia and malnutrition.
Background: Few studies have comprehensively analyzed the correlations among body composition parameters, muscle strength, and physical performance, as well as the influence of these factors on the postoperative complications and survival after radical gastrectomy for gastric cancer.
Methods: A prospective study was conducted including patients who underwent radical gastrectomy for gastric cancer from August 2014 to June 2019. Skeletal muscle index (SMI), skeletal muscle density (SMD), visceral fat area (VFA), subcutaneous fat area (SFA) was obtained by measurement of preoperative computed tomography (CT) images.
Nutritional risk and sarcopenia are both associated with increased postoperative morbidity and mortality following elective surgery. This study aimed to investigate whether sarcopenia has additional predictive value for postoperative complications and long-term survival besides nutritional screening tools. Clinical data of patients underwent radical gastrectomy for gastric cancer was prospectively collected.
View Article and Find Full Text PDFPurpose: The applicability of laparoscopic-assisted radical gastrectomy for elderly patients with gastric cancer is still not well clarified. The aim of this double-center study was to explore the feasibility and effectiveness of laparoscopic-assisted radical gastrectomy on elderly patients with gastric cancer.
Methods: We prospectively collected data of patients who underwent gastrectomy for cancer in two centers from June 2016 to December 2019.
This study aims to explore the impact of nuclear factor erythroid 2-related factor 2 (Nrf2) deficiency on skeletal muscle autophagy and the development of sarcopenia. LC3b, P62, Bnip3, Lamp-1, and AMPK protein levels were measured in muscle from young, middle-aged, old Nrf2-/- (knockout, KO) mice and age-matched wild-type (WT) C57/BL6 mice. Autophagy flux was measured in young WT, young KO, old WT, old KO mice, using colchicine as autophagy inhibitor.
View Article and Find Full Text PDFBackground: Sarcopenia is a negative predictor for postoperative recovery. This study was performed to evaluate the short-term outcomes of laparoscopic surgery in colorectal cancer patients with sarcopenia.
Methods: We conducted a study of patients who underwent curative surgeries for colorectal cancer in two centers from July 2014 to July 2018.
Background: In 2010, the European Working Group on Sarcopenia in Older People (EWGSOP) reached a consensus on sarcopenia (EWGSOP1). In 2018, the EWGSOP met again (EWGSOP2) to update original definition of sarcopenia. This study aimed to investigate the association of sarcopenia and survival and compare the prognostic effects of sarcopenia as defined by EWGSOP1 and EWGSOP2 after gastrectomy.
View Article and Find Full Text PDFBackground: We aimed to determine the safety and effectiveness of laparoscopic-assisted surgery (LAS) in visceral obesity patients with colorectal cancer (CRC).
Patients And Methods: We retrospectively collected the clinical data of consecutive patients who underwent colorectal surgery for CRC between August 2014 and July 2018. The third lumbar vertebra visceral fat area was measured to diagnose visceral obesity.
Background/aim: The aim of this prospective double-center study was to explore the effect of nutritional risk on short-term outcomes in the patients who had gastric cancer and underwent a laparoscopic-assisted gastrectomy.
Patients And Methods: We conducted a study of patients who underwent laparoscopic-assisted gastrectomy in two large centers between June 2014 and April 2017. Patients' demographic and clinical characteristics and postoperative short-term outcomes were prospectively analyzed.
Background: Postoperative fatigue syndrome (POFS) is a common clinical complication followed by almost every major abdominal surgery. Ginsenoside Rb1 (GRb1), a principle ginsenoside in ginseng, could exert a potent anti-fatigue effect on POFS. However, the mechanism is still unknown.
View Article and Find Full Text PDF