Publications by authors named "Qian-Ting Yuan"
GPR84 regulates pulmonary inflammation by modulating neutrophil functions.
Acta Pharmacol Sin
August 2023
Acute lung injury (ALI) is an acute, progressive hypoxic respiratory failure that could develop into acute respiratory distress syndrome (ARDS) with very high mortality rate. ALI is believed to be caused by uncontrolled inflammation, and multiple types of immune cells, especially neutrophils, are critically involved in the development of ALI. The treatment for ALI/ARDS is very limited, a better understanding of the pathogenesis and new therapies are urgently needed.
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- GPR84, a G protein-coupled receptor found in myeloid immune cells, is significantly increased during inflammation and may contribute to inflammatory diseases.
- Research shows that GPR84 is upregulated in active ulcerative colitis (UC) patients and in mice with induced colitis, with a notable rise in GPR84-expressing macrophages in the affected colon tissues.
- Antagonizing GPR84 with CLH536 decreases inflammation by inhibiting the activation of pro-inflammatory macrophages, indicating GPR84 as a potential therapeutic target for UC.