P22077 inhibits LPS-induced inflammatory response by promoting K48-linked ubiquitination and degradation of TRAF6.

Inflammation is a biological process associated with multiple human disorders such as autoimmune diseases and metabolic diseases. Therefore, alleviation of inflammation is important for disease prevention or treatment. Recently, deubiquitinating enzymes (DUBs), especially ubiquitin specific protease-7 (USP7) attracts increasing attention as a potential drug target for inflammation.

Metabolites as Probes to Identify a COX-2 Active Site and as in Vitro and in Vivo Anti-Inflammatory Agents.

(±)-Dispirocochlearoids A-C (-), meroterpenoids with a 6/6/5/6/6/6 ring system, were isolated from . - are selective COX-2 inhibitors with an IC value of (-)- at 386 nM. Site-directed mutagenesis identified His351 as a COX-2 active site.