Publications by authors named "Qian-Nan Sun"
Background: Scarce research has reported the efficacy and safety of laparoscopic distal gastrectomy in elderly patients. This retrospective study aimed to compare the outcomes of laparoscopic and open distal gastrectomy for advanced gastric cancer in elderly patients.
Methods: A total of 303 elderly patients who underwent distal gastrectomy for advanced gastric cancer from June 2017 to June 2021 were enrolled.
Purpose: Scarce research has reported the comparison between robotic and laparoscopic surgery in mid-low rectal cancer. Therefore, this meta-analysis is aimed to compare the safety and efficacy of the two surgical approaches.
Methods: A comprehensive search of the databases (PubMed, EMBASE, Cochrane, and Web of Science) was performed for studies comparing robotic and laparoscopic surgery.
Article Synopsis
- This study compared two surgical techniques (intracorporeal vs. extracorporeal) used in left hemicolectomy to see which is more effective.
- The analysis reviewed data from 7 studies, looking at various outcomes such as surgery time and recovery rates.
- Results showed that the intracorporeal method led to shorter incisions, fewer complications, faster recovery times, and shorter hospital stays compared to the extracorporeal method.
Scarce research has been performed to assess the safety and efficacy of anastomosis technique on robotic-assisted sigmoidectomy. This study was designed to evaluate the difference between intracorporeal and extracorporeal techniques during robotic-assisted sigmoidectomy. Clinical data of 193 cases who received robotic-assisted sigmoidectomy were retrospectively collected and analyzed.
View Article and Find Full Text PDFThe present study aimed to investigate the potential molecular mechanisms by which galectin‑1 (Gal‑1) and glucose‑regulated protein 78 (GRP78) influence the development of malignant gastric cancer (GC). Immunohistochemistry and western blotting were used to map the expression and location of the Gal‑1 gene in the 80 paraffin‑embedded GC samples, 16 fresh samples and surrounding tissues. Gal‑1 was overexpressed and knocked down using lentiviral vectors in the human GC cell lines HGC‑27 and AGS.
View Article and Find Full Text PDFLow Tumor Infiltrating Mast Cell Density Reveals Prognostic Benefit in Cervical Carcinoma.
Technol Cancer Res Treat
June 2022
Article Synopsis
- The study investigates the role of mast cells (MCs) in the immune response to cervical carcinoma (CC), utilizing data from The Cancer Genome Atlas (TCGA) to evaluate their prognostic significance.
- Findings reveal that low mast cell density (MCD) correlates with better overall survival in patients, indicating that high infiltration of MCs may have a negative impact on patient outcomes.
- Additionally, the research identifies key genes related to inflammatory and immune responses, suggesting that the interaction between MCs and cytokines in the tumor microenvironment could serve as potential targets for prognostic evaluation and immunotherapy in CC.
Article Synopsis
- Endometrial cancer (EC) is a common type of cancer in women, and one of the main problems is that it can spread to other parts of the body, making it harder to treat.
- A gene called eIF4E is found in high amounts in EC, which is linked to worse outcomes for patients, while two microRNAs, miR-320a and miR-340-5p, are lower in EC and may help stop cancer growth.
- When miR-320a and miR-340-5p are increased in EC cells, they can slow down the cancer's ability to move and invade other areas by lowering certain proteins that help with these processes.