Sodium butyrate protects against lipopolysaccharide-induced liver injury partially via the GPR43/ β-arrestin-2/NF-κB network.

Background: Butyrate acts as a regulator in multiple inflammatory organ injuries. However, the role of butyrate in acute liver injury has not yet been fully explored. In the present study, we aimed to investigate the association between butyrate and lipopolysaccharide (LPS)-induced acute liver injury and the signaling pathways involved.

β-arrestin 2 attenuates lipopolysaccharide-induced liver injury inhibition of TLR4/NF-κB signaling pathway-mediated inflammation in mice.

Aim: To study the role and the possible mechanism of β-arrestin 2 in lipopolysaccharide (LPS)-induced liver injury and .

Methods: Male β-arrestin 2 and β-arrestin 2 C57BL/6J mice were used for experiments, and the mouse macrophage cell line RAW264.7 was used for experiments.