A novel effect of imidazole derivative KK-42 on increasing survival of Aeromonas hydrophila challenged prawn Macrobrachium nipponense.

Imidazole derivative KK-42 is well known as the insect growth regulator. Here we find that KK-42 pretreatment could promote the survival of Macrobrachium nipponense infected with Aeromonas hydrophila, which is considered to be possibly related to the prophenoloxidase (proPO), a conserved copper-containing enzyme that plays an important role in defense against pathogens. In this study, a full-length of proPO gene from M.

[Progress in the research of antizyme].

Antizyme is a small protein induced by elevated intracellular polyamines. Antizyme binds specifically to ornithine decarboxylase (ODC) , targeting ODC for ubiquitin-independent degradation by the 26S protosome, which consequently reduces polyamine synthesis. Polyamine transport may also be regulated by antizyme, through which the cellular polyamine levels are maintained.

Expression patterns and action analysis of genes associated with drug-induced liver diseases during rat liver regeneration.

Aim: To study the action of the genes associated with drug-induced liver diseases at the gene transcriptional level during liver regeneration (LR) in rats.

Methods: The genes associated with drug-induced liver diseases were obtained by collecting the data from databases and literature, and the gene expression changes in the regenerating liver were checked by the Rat Genome 230 2.0 array.