Nanoparticles targeting OPN loaded with BY1 inhibits vascular restenosis by inducing FTH1-dependent ferroptosis in vascular smooth muscle cells.

Vascular restenosis following angioplasty continues to pose a significant challenge. The heterocyclic trioxirane compound [1, 3, 5-tris((oxiran-2-yl)methyl)-1, 3, 5-triazinane-2, 4, 6-trione (TGIC)], known for its anticancer activity, was utilized as the parent ring to conjugate with a non-steroidal anti-inflammatory drug, resulting in the creation of the spliced conjugated compound BY1. We found that BY1 induced ferroptosis in VSMCs as well as in neointima hyperplasia.

The Synthesis, Bonding, and Transformation of a Ligand-Protected Gold Nanohydride Cluster.

Gold does not react with H to form bulk hydrides. Here we report the synthesis and characterization of a gold nanohydride protected by diphosphine ligands, [Au H (dppo) ] [dppo=1,8-bis(diphenylphosphino)octane]. The Au core consists of two Au units bonded by eight Au atoms not coordinated by the diphosphine ligands.

Halogen effects on the electronic and optical properties of Au nanoclusters.

We report an experimental and theoretical investigation of the electronic and optical properties of a series of icosahedral Au nanoclusters, protected using different halogen ligands (Cl, Br, and I), as well as 1,2-bis(diphenylphosphino)ethane (dppe) ligands. All three clusters are comprised of the same Au kernel with two halogens coordinated to the poles of the icosahedral cluster along with five dppe ligands. UV-vis absorption spectra indicate a systematic red shift from Cl to Br to I, as well as a sudden enhancement of the second excitonic peak for the I-coordinated cluster.

Nitrogen-containing flavonoid and their analogs with diverse B-ring in acetylcholinesterase and butyrylcholinesterase inhibition.

In this study, a series of new flavones (2-phenyl-chromone), 2-naphthyl chromone, 2-anthryl-chromone, or 2-biphenyl-chromone derivatives containing 6 or 7-substituted tertiary amine side chain were designed, synthesized, and evaluated in acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition. The results indicated that the alteration of aromatic ring connecting to chromone scaffold brings about a significant impact on biological activity. Compared with flavones, the inhibitory activity of 2-naphthyl chromone, 2-anthryl-chromone derivatives against AChE significantly decreased, while that of 2-biphenyl chromone derivatives with 7-substituted tertiary amine side chain is better than relative flavones derivatives.

Recyclable and superior selective CO adsorption of CB and Ca@CB: a new category of perfect cubic heteroborospherenes.

The capture and separation of CO2 have attracted significant interest as a strategy to control the global emission of greenhouse gases. From the perspective of environmental protection, it is crucial to explore high-performance adsorbents that can efficiently capture CO2. Herein, we report a density functional theory study on the viability of the heteroborospherene C4B32 for the first time.

Toward Solution Syntheses of the Tetrahedral Au Pyramid and Atomically Precise Gold Nanoclusters with Uncoordinated Sites.

A long-standing objective of cluster science is to discover highly stable clusters and to use them as models for catalysts and building blocks for cluster-assembled materials. The discovery of catalytic properties of gold nanoparticles (AuNPs) has stimulated wide interests in gaseous size-selected gold clusters. Ligand-protected AuNPs have also been extensively investigated to probe their size-dependent catalytic and optical properties.

Probing the interaction between the encapsulated water molecule and the fullerene cages in HO@C and HO@CN.

We report a high-resolution photoelectron imaging study of cryogenically-cooled HO@C and HO@CN endohedral fullerene anions. The electron affinity (EA) of HO@C is measured to be 2.6923 ± 0.

Elucidation of the Formation Mechanisms of the Octahydrotriborate Anion (BH) through the Nucleophilicity of the B-H Bond.

Boron compounds are well-known electrophiles. Much less known are their nucleophilic properties. By recognition of the nucleophilicity of the B-H bond, the formation mechanism of octahydrotriborate (BH) was elucidated on the bases of both experimental and computational investigations.

[(CpM)BH] (M = Zr or Hf): early transition metal 'guarded' heptaborane with strong covalent and electrostatic bonding.

Among the series of stable -borate dianions, [B H ], the X-ray crystallographic structure of [BH] was determined only in 2011. To explore its chemistry and stability, we have isolated and structurally characterized two new transition metal complexes of the heptaborane, [(CpM)BH] (Cp = η-CH; M = Zr or Hf). The structures of [(CpM)BH] contain a pentagonal bipyramidal B core, coordinated by two {CpM} and two {BH} units equatorially.

High-Resolution Photoelectron Imaging of Cryogenically-Cooled CN and (CN) Azafullerene Anions.

We report a photoelectron imaging study of cryogenically cooled CN and (CN) anions produced from electrospray ionization. High-resolution photoelectron spectra are obtained for CN for the first time, allowing seven vibrational frequencies of the CN azafullerene to be measured. The electron affinity of CN is determined accurately to be 3.

Diphosphine-Protected Au Nanoclusters on Oxide Supports Are Active for Gas-Phase Catalysis without Ligand Removal.

Investigation of atomically precise Au nanoclusters provides a route to understand the roles of coordination, size, and ligand effects on Au catalysis. Herein, we explored the catalytic behavior of a newly synthesized Au(L) nanocluster (L = 1,8-bis(diphenylphosphino) octane) with in situ uncoordinated Au sites supported on TiO, CeO, and AlO. Stability of the supported Au nanoclusters was probed structurally by in situ extended X-ray absorption fine structure (EXAFS) and high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM), and their ability to adsorb and oxidize CO was investigated by IR absorption spectroscopy and a temperature-programmed flow reaction.

Chiral phosphoric acid-catalyzed asymmetric transfer hydrogenation of 3-trifluoromethylthioquinolines.

A chiral phosphoric acid-catalyzed asymmetric transfer hydrogenation of 3-trifluoromethylthioquinolines has been successfully developed, providing direct and facile access to chiral 2,3-disubstituted 1,2,3,4-tetrahydroquinoline derivatives containing a stereogenic trifluoromethylthio group with up to 99% enantioselectivity.

Catalyst design based on agostic interactions: synthesis, characterization, and catalytic activity of bis(pyrazolyl)borate copper complexes.

Agostic interactions are often used to activate inert C-H bonds, and thus facilitate new reactions. We report the first example of designed catalysts based on the agostic interaction. Novel copper(i) complexes [BBN(pz(x))2]Cu(PPh3)n (BBN = 9-borabicyclo[3.

Polymorphism of Phosphine-Protected Gold Nanoclusters: Synthesis and Characterization of a New 22-Gold-Atom Cluster.

A new Au22 nanocluster, protected by bis(2-diphenyl-phosphino)ethyl ether (dppee or C28 H28 OP2 ) ligand, has been synthsized and purified with high yield. Electrospray mass spectrometry shows that the new cluster has a formula of Au22 (dppee)7 , containing 22 gold atoms and seven dppee ligands. The cluster is found to be stable as a solid, but metastable in solution.

Synthesis and structure determination of a new Au(20) nanocluster protected by tripodal tetraphosphine ligands.

We report the synthesis and structure determination of a new Au20 nanocluster coordinated by four tripodal tetraphosphine (PP3) ligands {PP3 = tris[2-(diphenylphosphino)ethyl]phosphine}. Single-crystal X-ray crystallography and electrospray ionization mass spectrometry show that the cluster assembly can be formulated as [Au20(PP3)4]Cl4. The Au20 cluster consists of an icosahedral Au13 core and a seven-Au-atom partial outer shell arranged in a local C3 symmetry.

Controlling gold nanoclusters by diphospine ligands.

We report the synthesis and structure determination of a new Au22 nanocluster coordinated by six bidentate diphosphine ligands: 1,8-bis(diphenylphosphino) octane (L(8) for short). Single crystal X-ray crystallography and electrospray ionization mass spectrometry show that the cluster assembly is neutral and can be formulated as Au22(L(8))6. The Au22 core consists of two Au11 units clipped together by four L(8) ligands, while the additional two ligands coordinate to each Au11 unit in a bidentate fashion.