Therapeutic Effects and Mechanisms of Alcohol Extracts from Polygala fallax Hemsl on Endometriosis in Rats.

Endometriosis is a chronic estrogen-dependent inflammatory disease that significantly affects women's health. Polygala fallax Hemsl. (PFH), a traditional Zhuang medicine, has been frequently used for gynecological disorders.

Exploring the Dual Nature of Integrated Crop-Livestock Systems: A Review of Environmental Benefits and Risk Challenges.

Integrated crop-livestock systems (ICLS) are acknowledged as both productive and environmentally sustainable, with notable potential to optimize resource use, enhance ecosystem services, and boost crop yields. However, manure application, a critical component of ICLS, may amplify negative environmental impacts, particularly the risks associated with emerging pollutants, which remain underexplored and insufficiently understood. This comprehensive review seeks to thoroughly evaluate the environmental benefits of ICLS.

Incidence of arterial and venous thromboembolism in cancer patients- insights from more than 5,000,000 patients.

The reported incidence of arterial thromboembolism (ATE) and venous thromboembolism (VTE) after cancer varies. A meta-analysis was performed to define the incidence of thromboembolism (TE) in cancer patients. Articles were searched in PubMed and Embase from inception to November 1, 2023.

Pd-O-Ti dual sites for efficient electrochemical active hydrogen generation and bromate reduction.

Atomic hydrogen (H*) plays a crucial role in electrochemical reduction technology towards various environmental and energy applications, but suffers from low utilization efficiency arisen from the undesirable H-H dimerization and the competitive adsorption between water molecule with reactants on the traditional adjacent catalytic sites. Herein, we anchored Pd single atoms on the naturally formed titanium oxide of titanium foam to construct Pd-O-Ti dual-site electrocatalyst with spatially isolated water dissociation and H* utilization site, which synchronously inhibits the H-H dimerization and the competitive adsorption of water molecule and targeted reactants. Experiments and theoretical calculations revealed that the Ti-O sites could synergistically dissociate water to H*, which overflowed to nearby Pd single-atom sites for designed reduction reactions and utilization benefiting from the hydrogen spillover ability of titanium oxide substrate.

Quantitative Ultrasonic Backscatter Evaluation of Elastic and Mechanical Property in a Rabbit Tendinopathy Healing Model.

Objective: This study investigates the feasibility of non-invasive ultrasound backscatter techniques for quantitative tendon characterization.

Methods: Sixty-six New Zealand white rabbits were divided into three groups: normal control group (NC group), model control group (MC group), and low-intensity pulsed ultrasound (LIPUS) treatment group (LT group). Tendinopathy models were induced in MC and LT groups, with the LT group receiving LIPUS intervention and the MC group receiving sham ultrasound therapy.

The impact of integrated genomic analysis on molecular classifications and prognostic risk stratification in endometrial cancer: a Chinese experience.

Background: The molecular classification of endometrial cancer (EC), as proposed by The Cancer Genome Atlas (TCGA), has transformed tumor classification, but there is a lack of extensive research on the molecular profiles and subtyping of endometrial cancer patients in China.

Methods: 200 EC patients were classified into the following four molecular types: (i) POLEmut; (ii) MSI-H; (iii) TP53mut; (iv) NSMP. This study aimed to investigate the molecular characteristics of EC patients at a single center by large-scale next generation sequencing(NGS), including clinicopathological features and gene mutations in patients with distinct molecular types, and to assess the relevance of molecular subtyping for postoperative adjuvant therapy.

Predicting Surgical and Non-surgical Curvature Correction by Radiographic Spinal Flexibility Assessments for Patients With Adolescent Idiopathic Scoliosis: A Systematic Review and Meta-Analysis.

Study Design: Systematic Review and Meta-analysis.

Objectives: This systematic review and meta-analysis aimed to: (1) synthesize the prevalent application ratios of 2 radiographic spinal flexibility assessment methods in AIS patients treated with PSF or bracing; and (2) quantitatively evaluate the accuracy of these methods in predicting post-intervention correction outcomes.

Methods: A systematic search was conducted across 5 electronic databases: CINAHL, Embase, Ovid, PubMed, and Web of Science.

Predictors of para-aortic lymph node metastasis based on pathological diagnosis via surgical staging in patients with locally advanced cervical cancer: A multicenter study.

Para-aortic lymph node (PALN) metastasis of patients with locally advanced cervical cancer (LACC) is associated with multiple risk factors. This study aimed to identify risk factors and develop a predictive model for PALN metastasis based on the pathological diagnosis via surgical staging to determine the patient-population suitable for extended-field irradiation (EFRT) and clarify the prognosis of patients with LACC. Five parameters were identified as predictors by logistic regression analysis.

Solar-driven selective conversion of millimolar dissolved carbon to fuels with molecular flux generation.

The direct utilization of dissolved inorganic carbon in seawater for CO conversion promises chemical production on-demand and with zero carbon footprint. Photoelectrochemical (PEC) CO reduction (COR) devices promise the sustainable conversion of dissolved carbon in seawater to carbon products using sunlight as the only energy input. However, the diffusion-dominant transport mechanism and the near-zero concentration of CO(aq) (CO dissolved in aqueous solution) in static seawater has made it extremely challenging to achieve high solar-to-fuel (STF) efficiency and high carbon-product selectivity.

Design of Intrinsic Transparent Conductors from a Synergetic Effect of Symmetry and Spatial-Distribution Forbidden Transitions.

Intrinsic transparent conductors (ITCs) correspond to a unique class of TCs that do not need intentional doping. This character can provide ITCs significant advantages by avoiding severe "doping bottlenecks" and dopant scattering usually encountered in conventional transparent conducting oxides (TCOs). However, the realization of ITCs generally requires the minimization of photon absorption and reflection in metallic conductors, which is difficult due to the gapless nature of their band structures.

A Multi-Component Reaction Peptide Augmenting the Anti-Aging Benefits of Non-Ablative Laser Procedure.

Background: Laser resurfacing is one of the most popular aesthetic procedures that address a wide range of skin conditions and overall skin rejuvenation. To reduce downtime and improve the clinical efficacy of the procedures, it is important to design post-procedure care routines to complement them. Towards fulfilling that consumer need, a peptide synthesized from multi-component reaction (MCP) has been developed.

Hit to lead optimization of the 4-trifluoromethylquinoline derivatives as novel SGK1 inhibitors with potent anti-prostate cancer activity.

Prostate cancer (PCa) remains a significant health concern for males, and serum/glucocorticoid-regulated kinase-1 (SGK1) plays a crucial role in its pathogenesis. This provides a promising target for the development of novel therapies against PCa. Herein, we reported the structural optimization of the hit compound H1, which was discovered in our previous work as an SGK1 inhibitor.

Bio-plausible reconfigurable spiking neuron for neuromorphic computing.

Biological neurons use diverse temporal expressions of spikes to achieve efficient communication and modulation of neural activities. Nonetheless, existing neuromorphic computing systems mainly use simplified neuron models with limited spiking behaviors due to high cost of emulating these biological spike patterns. Here, we propose a compact reconfigurable neuron design using the intrinsic dynamics of a NbO-based spiking unit and excellent tunability in an electrochemical memory (ECRAM) to emulate the fast-slow dynamics in a bio-plausible neuron.

BMAL1 rescued the hippocampus-dependent recognition memory induced by sleep deprivation.

Sleep plays an important role in the process of memory. This study investigated the role of the circadian clock gene, BMAL1 of the master circadian clock in mediating the impairment of hippocampus-dependent recognition memory caused by sleep deprivation. After 4 weeks of sleep deprivation, the novel object recognitiontask was used to evaluate the recognition memory of mice, the expression levels of circadian clock genes, and Nrf2 and PKA/CREB/BDNF signal pathways were detected by Western blot, Realtime-qPCR, and immunofluorescence.

Multi-scale comparison of the formation mechanisms in landscape genes of traditional villages.

The relationship between traditional village landscape genes and the geographical environment is closely intertwined, exhibiting notable spatial differences and cultural characteristics during scale transformations. To effectively elucidate the formation mechanisms of these landscape genes, it is essential to construct a multi-scale analytical framework that integrates multiple dimensions. This paper address these challenges by expanding the sample selection range and combining both qualitative and quantitative analyses of landscape genes across various scales.

Dapagliflozin alleviated seizures and cognition impairment in pilocarpine induced status epilepticus via suppressing microglia-mediated neuroinflammation and oxidative stress.

Background: Status epilepticus (SE) is a neurological emergency with prolonged seizures leading to chronic epilepsy, cognitive impairment, and neuronal damage. Microglial activation, subsequent neuroinflammation and oxidative stress contribute to SE-induced neuronal injury. Single-cell sequencing has delineated the pro-inflammatory microenvironment in epileptic lesions, characterized by widespread microglial activation.

Advancing the Fight Against Cervical Cancer: The Promise of Therapeutic HPV Vaccines.

Human papillomavirus (HPV) is a major global health issue and is recognized as the leading cause of cervical cancer. While prophylactic vaccination programs have led to substantial reductions in both HPV infection rates and cervical cancer incidence, considerable burdens of HPV-related diseases persist, particularly in developing countries with inadequate vaccine coverage and uptake. The development of therapeutic vaccines for HPV represents an emerging strategy that has the potential to bolster the fight against cervical cancer.

Histological and Molecular Manifestations of Cleft Myopathy.

Objective: Apart from rupture and displacement of muscle fibers, structural defects exist in cleft muscles but have not been adequately investigated. This study aimed to examine the histological and molecular features of the cleft muscles.

Design: Orbicularis oris (OO) and tensor fasciae latae (TFL) muscle samples were obtained from patients with cleft lip and alveolar.

High-efficiency Pb removal by hydroxy-sodalite for point-of-use drinking water purification.

The development of cost-effective point-of-use (POU) devices that effectively remove lead (Pb) from drinking water is imperative in mitigating the threat of Pb contamination to public health in underdeveloped regions. Herein, we have successfully transformed inexpensive natural kaolinite as hydroxy-sodalite (HySOD) via a simple hydrothermal process, achieving an impressive yield of 91.5 %.

Oligo-FISH barcode chromosome identification system provides novel insights into the natural chromosome aberrations propensity in the autotetraploid cultivated alfalfa.

Alfalfa is one of the most economically valuable forage crops in the world. However, molecular cytogenetic studies in alfalfa lag far behind other cash crops and have reached a bottleneck. Here, we developed a novel chromosome identification system by designing 21 oligo probes in specific regions of each chromosome, which can be used as a barcode to simultaneously distinguish all chromosomes in a cell.

Highly proliferating cancer cells function as novel prognostic biomarkers for lung adenocarcinoma with particular usefulness for stage IA risk stratification.

Background: The refinement of risk stratification in lung adenocarcinoma (LUAD) plays a pivotal role in advancing precision medicine; however, the current staging classification falls short of comprehensiveness, particularly in the case of stage IA patients. We aimed to molecularly stratify LUAD patients especially for stage IA.

Methods: We analysed tumour heterogeneity and identified highly proliferating cancer cells (HPCs) in LUAD by performing single-cell RNA sequencing (scRNA-seq) analysis, immunohistochemical (IHC) staining using a tissue microarray, flow cytometry and biological experiments.

Effect of Asphalt Granulation on the Performance of Artificial Graphite Anode Materials for Lithium-Ion Batteries.

In order to investigate the effects of the softening point, the addition ratio, and the median particle size (D50) of the asphalt on the performance of secondary particles of artificial graphite anode materials prepared by granulation, ten-kilogram orthogonal experiments were designed. D50 and powder orientation index (OI) value of the prepared secondary particles of artificial graphite anode materials were employed as evaluation index, and the results of the orthogonal experiments were subjected to polarity analysis, analysis of variance (ANOVA), and multiple linear regression analysis. It is demonstrated that the addition ratio of the asphalt exerts the most pronounced influence on D50 and powder OI value of secondary granular artificial graphite anode materials, followed by the softening point.

Comparison of two different secondary rhinoplasties in patients with complete unilateral cleft lip and palate.

Background: The purpose of this study was to analysis the nostril symmetry and nasal stability following secondary rhinoplasty performed with either nasal septal cartilage implantation (G1) or simple alar cartilage suspension and internal fixation (G2) in patients with unilateral secondary cleft nasal deformity.

Methods: Nostril and alar symmetry were analyzed retrospectively in 13 consecutive patients in G1 and 17 in G2. Assessment of three indexes was first performed using photogrammetric measurements of photographs at pre-operation(T1), 7 days after repair (T2), and at least 6 months after repair (T3).

Precise diagnosis and prognosis assessment of malignant lung nodules: a narrative review.

Background And Objective: Pulmonary nodules (PNs) are small (≤3 cm) radiographic opacities within lung parenchyma. The use of low-dose computed tomography (LDCT) has led to a significant increase in the identification of solitary nodules. Malignant lung nodules comprise only 5% of all nodules, with management differing greatly from benign cases.

Transglutaminase 2 regulates endothelial cell calcification via IL-6-mediated autophagy.

Introduction: Endothelial cell (EC) calcification is an important marker of atherosclerotic calcification. ECs play a critical role not only in atherogenesis but also in intimal calcification, as they have been postulated to serve as a source of osteoprogenitor cells that initiate this process. While the role of transglutaminase 2 (TG2) in cellular differentiation, survival, apoptosis, autophagy, and cell adhesion is well established, the mechanism underlying the TG2-mediated regulation of EC calcification is yet to be fully elucidated.