Apatinib Mesylate Inhibits Cell Proliferation and the Metastasis of Esophageal Squamous Cell Carcinoma Through ERK/ELK-1/Snail Pathway.

This study aimed to evaluate the impact of apatinib (APT) mesylate on the growth, migration ability, and underlying mechanisms in esophageal squamous cell carcinoma (ESCC) cell lines Kyse30 and Kyse150. Additionally, the anti-metastatic effects of APT mesylate were further validated in a nude mouse xenograft metastasis model. In vitro, APT mesylate treatment significantly reduced cell viability and migration ability in both cell lines in a dose- and time-dependent manner.

LcMYB5, an R2R3-MYB family gene from Lonicera caerulea L., enhances drought and salt tolerance in transgenic tobacco and blue honeysuckle.

MYB transcription factors exert crucial functions in enhancing plant stress tolerance, which is impacted by soil drought and salinity. In our study, the R2R3-type MYB transcription factor gene LcMYB5 from blue honeysuckle (Lonicera caerulea L.) was successfully cloned and identified, and confirmed its nuclear localization.

High-Quality SnSe Thin Films for Self-Powered Devices and Multilevel Information Encryption.

As semiconductor technology advances toward miniaturization and portability, thin films with excellent thermoelectric performance have garnered increasing attention, particularly for applications in self-powered devices and temperature-responsive sensors. The high Seebeck coefficient of SnSe thin films makes them promising for temperature sensing, but their poor electrical conductivity limits their potential as thermoelectric generators. In this work, high-quality -axis oriented SnSe thin films were deposited on quartz substrates by using magnetron sputtering.

F-CPI: A Multimodal Deep Learning Approach for Predicting Compound Bioactivity Changes Induced by Fluorine Substitution.

Fluorine (F) substitution is a common method of drug discovery and development. However, there are no accurate approaches available for predicting the bioactivity changes after F-substitution, as the effect of substitution on the interactions between compounds and proteins (CPI) remains a mystery. In this study, we constructed a data set with 111,168 pairs of fluorine-substituted and nonfluorine-substituted compounds.

Development and evaluation of pH-sensitive Euryale ferox starch-based films containing nano-SiO and Chinese rose (Rosa chinensis) extract for freshness monitoring of chicken breast meat.

In this study, smart films of EFS, EFS-SiO and EFS-SiO-CRE were successfully developed by using Euryale ferox starch (EFS), nano-SiO and Chinese rose extract (CRE). The Chinese rose flower had a high content of anthocyanins (1.73 mg/g) and CRE exhibited different colors in varying pH buffers (2-13).

Dynamic formation of melanoidins and parallel competitive pathways during sludge thermal hydrolysis affected by heating temperature.

The melanoidins formed through the Maillard reaction during thermal hydrolysis pretreatment (THP) of sludge contribute to darkening, refractoriness, and inhibition of effective wastewater and sludge treatment. However, the dynamic production and structural evolution of THP-derived melanoidins are not fully understood. This study aimed to investigate the factors influencing melanoidins production and the associated mechanisms during THP.

Establishment of a risk prediction model for peripherally inserted central catheter-related bloodstream infections based on a systematic review and meta-analysis of 20 cohorts.

Background: Peripherally inserted central catheters (PICCs) are commonly used for extended intravenous therapy but are associated with a significant risk of bloodstream infections (BSIs), which increase morbidity and healthcare costs.

Aim: The aim of this study was to identify patients at high risk of developing PICC-related bloodstream infections (PICC-RBSIs) to establish new and more specific targets for precise prevention and intervention.

Methods: A search was conducted from the earliest available record to May 2024 among the following databases: Embase, MEDLINE, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web of Science, Scopus, and Chinese National Knowledge Infrastructure (CNKI).

AI-driven system for non-contact continuous nocturnal blood pressure monitoring using fiber optic ballistocardiography.

Continuous monitoring of nocturnal blood pressure is crucial for hypertension management and cardiovascular risk assessment. However, current clinical methods are invasive and discomforting, posing challenges. These traditional techniques often disrupt sleep, impacting patient compliance and measurement accuracy.

Water-soluble polysaccharides from Torreya grandis nuts: Structural characterization and anti-inflammatory activity.

Torreya grandis (T. grandis) nuts are widely consumed as a functional food in China. In this study, we investigated the structural characteristics of T.

The effect of maternal dietary polyphenol consumption on offspring metabolism.

The early intrauterine environment of mothers during pregnancy significantly affects the metabolic health of their offspring. Existing studies suggest that poor maternal nutrition during pregnancy increases the risk of obesity or diabetes in offspring, so it is highly important to intervene during pregnancy to prevent metabolic disorders in mothers and their offspring. Polyphenols with anti-inflammatory and antioxidant properties are found in many foods and have protective effects on obesity, diabetes, cancer, and cardiovascular disease.

Current status of vocational delay of gratification among practicing nursing students and its influencing factors: a cross-sectional study.

Background: Practicing nursing students play a critical role in addressing the nursing workforce shortage. Their vocational delay of gratification influences career planning and practice quality. This study aimed to assess the level of vocational delay of gratification among nursing students and identify its influencing factors.

Continuous renal replacement therapy with adsorbing filter oXiris in the treatment of sepsis associated acute kidney injury: a single-center retrospective observational study.

Background And Objective: Critical bedside ultrasound is widely used in clinical practice, and it can monitor renal perfusion. The reduction of renal perfusion and inflammatory injury are two contributing factors to sepsis-associated acute kidney injury (SA-AKI).The aim of this study was to examine whether the oXiris filter was useful in the continuous renal replacement therapy(CRRT) treatment of SA-AKI patients.

Transcriptomics and metabolomics insights into the seasonal dynamics of meat quality in yak on the Qinghai-Tibetan Plateau.

Background: Meat quality in yak is influenced by the fluctuation of nutritional composition in different grazing seasons on the Qinghai-Tibetan Plateau. However, the molecular mechanism underlying in yak meat remains unknown. Therefore, this study aimed to investigate the seasonal dynamics of meat quality in yak by transcriptomics and metabolomics techniques.

Prognostic feature based on androgen-responsive genes in bladder cancer and screening for potential targeted drugs.

Objectives: Bladder cancer (BLCA) is a tumor that affects men more than women. The biological function and prognostic value of androgen-responsive genes (ARGs) in BLCA are currently unknown. To address this, we established an androgen signature to determine the prognosis of BLCA.

Relationships among Helicobacter pylori seropositivity, the triglyceride-glucose index, and cardiovascular disease: a cohort study using the NHANES database.

Background: Helicobacter pylori (H. pylori), a widely prevalent pathogen that can be cured through relatively simple medical methods, is thought to be potentially associated with the risk of cardiovascular diseases (CVD), although controversy remains. Currently, it is unclear whether the triglyceride-glucose index (TGI), a classic indicator of insulin resistance, influences the relationship between H.

Optimal Combination of Different Selection and Mating Strategies on Exploiting Genetic Diversity and Genetic Gain in Small Pig Conservation Populations.

Both selection and mating systems are essential tools for breeders to conserve the genetic variance and improve the performance of livestock animals. How to effectively balance the genetic gain and inbreeding has always been an important issue in quantitative genetics research. In this study, a total of 11 selection methods, including random and truncation selection, six conventional selection methods, three different optimal contribution selection (OCS) methods and three mating strategies including random mating, minimum-coancestry mating based on pedigree (MCPed) and genomic information (MCmarker), were performed using stochastic simulations.

PLEK2: a potential biomarker for metastasis and prognostic evaluation in uveal melanoma.

Background: Uveal melanoma (UVM) is an aggressive tumor known for its high metastatic rate, making it necessary to delineate potential molecules that may promote the development of UVM. PLEK2 has been found to promote the progression and metastasis of some tumors, but its role in UVM has not yet been reported. Through this study, we hope to explore the effect of PLEK2 on the prognosis of UVM patients and to discover the potential functional role and intrinsic mechanism of PLEK2.

Identification and characterization of PpUGT91BP1 as a trillin synthase from Paris polyphylla.

Polyphyllins are the active ingredients of the medicinal plant Paris polyphylla. The biosynthesis of different types of polyphyllins all require the catalysis of glycosyltransferases. Even though significant efforts have been made to identify PpUGTs capable of catalyzing the initial glycosylation reaction, the specific glycosyltransferases responsible for the synthesis of trillin have not been reported in P.

Inappropriate Diet Exacerbates Metabolic Dysfunction-Associated Steatotic Liver Disease via Abdominal Obesity.

Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a refined categorization of non-alcoholic fatty liver disease (NAFLD), highlighting the intricate relationship between hepatic steatosis and metabolic dysfunction. Abdominal obesity (AO), a key diagnostic criterion for metabolic dysfunction, predominantly results from inappropriate diet and unhealthy dietary habits. To comprehensively investigate which dietary factors contribute to MASLD through AO and to understand the underlying biological mechanisms, we initially conducted a systematic review of meta-analysis articles in the PubMed database from the past decade, summarizing dietary factors that affect AO.

Influence of Elevated Potassium Fertilization on Structural and Functional Properties of Sweet Potato Root Tuber Starch.

Nine sweet potato varieties with different flesh colors were cultivated under uniform environmental conditions with potassium (K) fertilizer treatments at levels of 0, 22.5, and 45 kg/ha. The structural and functional properties of the starches were subsequently analyzed.

Unveiling van Hove Singularity-Boosted Photothermoelectric Response for Wearable Human-Radiation Detection.

Van Hove singularity (vHs), the singularity point of density of states (DOS) in crystalline solids, is a research hotspot in emerging phenomena such as light-matter interaction, superconducting, and quantum anomalous Hall effect. Although the significance of vHs in photothermoelectric (PTE) effect has been recognized, its integral role in electron excitation and thermoelectric effect is still unclear, particularly in the mid-infrared band that suffers from Pauli blockade in semimetals. Here, we unveil the Fermi-level-modulated PTE behavior in the vicinity of vHs in carbon nanotubes, employing ionic-liquid gating.

A common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity.

Autosomal recessive deficiency of the IFNAR1 or IFNAR2 chain of the human type I IFN receptor abolishes cellular responses to IFN-α, -β, and -ω, underlies severe viral diseases, and is globally very rare, except for IFNAR1 and IFNAR2 deficiency in Western Polynesia and the Arctic, respectively. We report 11 human IFNAR1 alleles, the products of which impair but do not abolish responses to IFN-α and -ω without affecting responses to IFN-β. Ten of these alleles are rare in all populations studied, but the remaining allele (P335del) is common in Southern China (minor allele frequency ≈2%).

Optical Zitterbewegung effect in arrays of helical waveguides.

Owing to its topological properties and band collapse, Floquet helical photonic lattices have gained increasing attention as a purely classical setting to realize the optical analogues of a wide variety of quantum phenomena. We demonstrate both theoretically and numerically that light propagation in an appropriately designed helical superlattice can exhibit spatial photonic Zitterbewegung effect, i.e.

Hyperbilirubinemia in a Patient Receiving Alectinib for Anaplastic Lymphoma Kinase Positive Non-Small-Cell Lung Cancer: A Histological Features.

Background: Alectinib is a second generation of anaplastic lymphoma kinase (ALK) inhibitor that has been approved for the treatment of advanced non-small-cell lung cancer (NSCLC) with ALK rearrangements. Hepatotoxicity is the most common adverse drug reaction. However, there is currently no published report on the pathologic findings of alectinib-induced hyperbilirubinemia.

Mimic metalloenzymes with atomically dispersed Fe sites in covalent organic framework membranes for enhanced CO photoreduction.

The massive CO emissions from continuous increases in fossil fuel consumption have caused disastrous environmental and ecological crises. Covalent organic frameworks (COFs) hold the potential to convert CO and water into value-added chemicals and O to mitigate this crisis. However, their activity and selectivity are very low under conditions close to natural photosynthesis.