Publications by authors named "Qian Yuan"

Impaired glucose uptake regulated by suppressed insulin receptor signaling is a key driving force of podocytopathies. The identification of potential therapeutic targets that mediate podocyte insulin receptor signaling holds significant clinical importance. Here, we observed a substantial reduction in PR domain-containing 16 (PRDM16) expression within damaged podocytes in both humans and mice.

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The degradation of animal carcasses can lead to rapid waste release (e.g., pathogenic bacteria, viruses, prions, or parasites) and also result in nutrient accumulation in the surrounding environment.

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Antibiotic resistance genes (ARGs) are a persistent harmful environmental pollutant, epidemic of ARGs thought to be a result of antibiotic misuse. Tannin acid (TA) is a natural plant compounds with bactericidal properties. Nowadays, TA is considered to be a potential replacement of antibiotics.

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Objective: This study aims to evaluate the diagnostic efficacy of a novel system called contrasted enhanced ultrasound thyroid imaging reporting and data system (CEUS TI-RADS) for benign and malignant thyroid nodules. We also seek to assess inter-observer agreement.

Methods: The study recruited 433 patients who underwent thyroid ultrasound (US) and CEUS between January 2019 and June 2023 at Affiliated Hospital of Guangdong Medical University.

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The rising demand for plant-based meat analogues presents challenges in replicating the sensory qualities of animal meat. This study investigates the impact of Pichia-derived porcine myoglobin (PMb) and bovine hemoglobin (BHb) on the flavor profile, sensory attributes, macrostructure, color, and texture of high-moisture extruded soy protein concentrate-wheat gluten. The addition of PMb and BHb significantly altered the flavor profile by decreasing aldehyde content (hexanal and nonanal), while the contents of ketones (2,3-octanedione and 3,5-octadien-2-one), pyrazines (2-ethyl-6-methylpyrazine), and furans (2-pentylfuran) were increased.

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Hydrogen evolution from water, catalyzed by solar energy, is a promising yet challenging endeavor. Small-sized catalysts usually exhibit high utilization and high performance in the hydrogen evolution field. However, the high surface energy tends to make them aggregate.

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Parathyroid hormone (PTH) is critical for regulating calcium and phosphate homeostasis, and its dysregulation contributes to osteoporosis. Current methods for precise control of PTH secretion are limited. This study explores chemogenetic tools to regulate PTH secretion in parathyroid chief cells via Gq/Gi signaling.

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Objectives: The relationship between sugar-sweetened beverage (SSB) intake and phenotypic age acceleration (PhenoAgeAccel) is unclear. The aim of this study was to explore the associations between the energy and timing of SSB intake and PhenoAgeAccel in adults.

Methods: A cross-sectional analysis was conducted using data from the National Health and Nutrition Examination Survey (NHANES) 2007-2010, which involved U.

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Ionic conductive hydrogels have attracted great attention due to their good flexibility and conductivity in flexible electronic devices. However, because of the icing and water loss problems, the compatibility issue between the mechanical properties and conductivity of hydrogel electrolytes over a wide temperature range remains extremely challenging to achieve. Although, antifreezing/water-retaining additives could alleviate these problems, the reduced performance and complex preparation methods seriously limit their development.

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Article Synopsis
  • Postoperative cognitive dysfunction (POCD) is a complication related to surgery involving cognitive decline, potentially influenced by neuroinflammation, ferroptosis, and mitochondrial fatty acid metabolism, particularly via the protein Carnitine palmitoyl transferase 1a (CPT1A).
  • The study used SVG P12 astrocytes to explore how CPT1A affects mitochondrial function, inflammation, and neuron damage by overexpressing or knocking down CPT1A and assessing the resulting changes in cellular conditions.
  • Results showed that higher levels of CPT1A improved mitochondrial function and reduced oxidative stress and inflammation in astrocytes, which benefitted neuron health, while these effects depended on functional mitochondrial respiration, as demonstrated when treatments disrupted this process.
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Background: The link between regional body fat distribution and overactive bladder (OAB) in prior epidemiological research has been uncertain. Our objective is to assess the relationship between increased regional body fat and the prevalence of OAB.

Methods: Within this analysis, 8,084 individuals aged 20 years and older were selected from NHANES surveys conducted from 2011 to 2018.

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Background: Kabuki syndrome is a genetic syndrome that affects multiple organs and systems. Gene mutations are the main cause of KS. Mutations in the KMT2D and KDM6A genes have been reported as two relatively clear pathogenic pathways.

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Introduction: Chronic kidney disease (CKD) is a substantial global health issue with high morbidity and mortality. Yishen Paidu Pills (YSPDP) are effective concentrated water pills composed of four herbs developed by Wuhan Union Hospital to treat CKD. However, the mechanism of YSPDP action is largely unknown.

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We sought to prospectively evaluate whether food protein-induced allergic proctocolitis (FPIAP) during infancy is associated with increased constipation later in childhood. Using the Gastrointestinal Microbiome and Allergic Proctocolitis (GMAP) cohort, we reviewed charts of children with prospective parent-reported constipation after age 3 to confirm the diagnosis of constipation. A diagnosis of FPIAP was based on pediatrician diagnosis and required guaiac-positive or grossly bloody stools, as previously published.

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Article Synopsis
  • The paper highlights the significant global health challenge posed by depression and explores how exercise can serve as an effective treatment option to mitigate this issue.
  • It outlines the mechanisms through which exercise, such as yoga and strength training, exerts antidepressant effects by influencing neurotransmitters, neuroplasticity, and hormone levels.
  • The study emphasizes the importance of personalized exercise programs tailored to individual needs to enhance treatment outcomes and calls for further research to fully understand exercise's impact on depression.
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Background: Immunoglobulin E (IgE) plays a pivotal role in the pathogenesis of allergic diseases by engaging with FcεRI and FcεRII receptors, triggering allergic responses. The development of anti-IgE antibodies, such as omalizumab, has introduced a targeted approach to allergy treatment by neutralizing free IgE and dampening the allergic cascade.

Summary: This review synthesizes the current understanding of IgE's role in allergic diseases and evaluates the clinical utility of omalizumab.

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Nonalcoholic fatty liver disease (NAFLD) has become a common health care burden worldwide. The high heterogeneity of NAFLD remains elusive and impairs outcomes of clinical diagnosis and pharmacotherapy. Several NAFLD classifications have been proposed on the basis of clinical, genetic, alcoholic, or serum metabolic analyses.

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Article Synopsis
  • Myoglobin from engineered fermentation is used as a color additive in meat alternatives, but its allergy potential is not well understood.
  • A study found no allergy-related proteins in porcine myoglobin, and simulated digestion indicated it was not very resilient to digestive processes.
  • Sensitization was observed in mice with specific antibodies showing allergic reactions, suggesting that the non-myoglobin protein part may cause these allergies, emphasizing the need for better purification methods.
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Head-to-tail sequences have been reported in human bocavirus (HBoV) 1-4. To reveal their features and functions, HBoV DNA was screened among respiratory specimens from pediatric patients with an acute respiratory infection (ARI) between April 2020 and December 2022, followed by HBoV genotyping. Head-to-tail sequences were detected using nested PCR, TA cloning, and Sanger sequencing, and these findings were confirmed by mNGS and amplicon sequencing.

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We previously reported that the peptide ST2-104 (CBD3, for Ca2+ channel-binding domain 3), derived from the collapsin response mediator protein 2 (CRMP2)-a cytosolic phosphoprotein, protects neuroblastoma cells against β-amyloid (Aβ) peptide-mediated toxicity through engagement of a phosphorylated CRMP2/NMDAR pathway. Abnormal aggregation of Aβ peptides (e.g.

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Background: Systemic immune-inflammation index (SII) is a novel comprehensive inflammatory marker. Inflammation is associated with impaired lung function. We aimed to explore the possible relationship between SII and lung function to examine the potential of SII in predicting lung function decline.

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Benefiting from the good electromechanical performance, ionic conductive hydrogel can easily convert the deformation into electrical signals, showing great potential in wearable electronic devices. However, due to the high water content, icing and water evaporation problems seriously limit their development. Although additives can ease these disadvantages, the accompanying performance degradation and complex preparation processes couldn't meet application needs.

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Spread through air spaces (STAS) represents a relatively novel concept in the pathology of lung cancer, and it specifically refers to the dissemination of tumour cells into the parenchymal air spaces adjacent to the primary tumour. In 2015, the World Health Organization (WHO) classified STAS as a new invasive form of lung adenocarcinoma (LUAD). Many studies investigated the role of STAS and revealed its association with the prognosis of LUAD and its influence on the outcomes of other malignant pulmonary neoplasms.

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