Still a long way to go, the potential of ChatGPT in personalized dietary prescription, from a perspective of a clinical dietitian.

Background: Prominent large language models, such as OpenAI's ChatGPT, have shown promising implementation in the field of nutrition. Special care should be taken when using ChatGPT to prescribe protein restricted diets for kidney impaired patients. The objective of the current study is to simulate a chronic kidney disease (CKD) patient and evaluate the capabilities of ChatGPT in the context of dietary prescription, with a focus on protein contents of the diet.

A novel spider toxin as a selective antagonist of the Kv1 subfamily of voltage-gated potassium channels through gating modulation.

Members of the voltage-gated potassium channel subfamily (Kv1) are essential for the nervous and immune systems, necessitating novel modulators and deeper insights into their structure-function relationships. While all known peptide inhibitors targeting Kv1 channels are pore blockers, we identified MrVIII (κ-HxTx-MrVIII), a novel peptide toxin from the venom of spider Macrothele raveni, as the first voltage-gating modifier antagonist with selective activity against Kv1 channels. MrVIII exhibits high-affinity inhibition of Kv1.

Integration of generalized additive models and hyperspectral imaging for quality prediction in Chaoshan beef meatballs: A comprehensive "raw materials-processing-quality-sensory" model.

Maintaining consistent quality of Chaoshan beef meatballs (CBMs) is challenging due to the intricate production processes and stringent raw material requirements, with no effective method currently available for real-time monitoring during production. In this study, a comprehensive "raw materials-processing-quality-sensory" network model to predict CBMs quality attributes by integrating generalized additive model (GAM) with (HSI) was developed. GAM showed strong predictive performance for key attributes such as the pH (R = 0.

Telemedicine in home enteral nutrition: a structured survey exploring acceptability, preferences and experiences among patients.

Background: Given that Telemedicine are widespread in China, and we have developed home enteral nutrition service with telemedicine (HENST) to satisfy HEN requirement of patients. However, only little is known about patient's experience of HENST model. The objective of this interview study was to explore patient's experiences and improvement direction of the HENST model.

Social contact patterns and their impact on the transmission of respiratory pathogens in rural China.

Introduction: Social contact patterns significantly influence the transmission dynamics of respiratory pathogens. Previous surveys have quantified human social contact patterns, yielding heterogeneous results across different locations. However, significant gaps remain in understanding social contact patterns in rural areas of China.

Injectable supramolecular hydrogel co-loading abemaciclib/NLG919 for neoadjuvant immunotherapy of triple-negative breast cancer.

The efficacy of cancer immunotherapy relies on a sufficient amount of functional immune cells. Triple-negative breast cancer lacks enough immune cell infiltration, and adjuvant therapy is necessary to prime anti-tumor immunity. However, the improvement in efficacy is unsatisfactory with concern about inducing systemic immunotoxicity.

Simultaneous monitoring of two comprehensive quality evaluation indexes of frozen-thawed beef meatballs using hyperspectral imaging and multi-task convolutional neural network.

The quality of beef meatballs during repeated freeze-thaw (F-T) cycles was assessed by multiple indicators. This study introduced a novel quality evaluation method using hyperspectral imaging (HSI) and multi-task learning. Seventeen quality indicators were analyzed to assess the impact of F-T cycles.

Serum exosomal small nucleolar RNA (snoRNA) signatures as a predictive biomarker for benign and malignant pulmonary nodules.

Low-dose CT (LDCT) is increasingly recognized as the preferred method for detecting pulmonary nodules. However, distinguishing whether a nodule is benign or malignant often necessitates repeated scans or invasive tissue sampling procedures. Therefore, there is a pressing need for non-invasive techniques to minimize unnecessary interventions.

Identification of candidate single-nucleotide polymorphisms (SNPs) and genes associated with sugarcane leaf scald disease.

Leaf scald, caused by Xanthomonas albilineans, is a severe disease affecting sugarcane worldwide. One of the most practical ways to control it is by developing resistant sugarcane cultivars. It is essential to identify genes associated with the response to leaf scald.

Muscle density, but not size, is independently associated with cognitive health in older adults with hip fractures.

Emerging evidence indicates a complex interplay between skeletal muscle and cognitive function. Despite the known differences between muscle quantity and quality, which can be measured via computed tomography (CT), the precise nature of their associations with cognitive performance remain underexplored. To investigate the links between muscle size and density and cognitive impairment (CI) in the older adults with hip fractures, we conducted a post hoc, cross-sectional analysis within a prospective cohort study on 679 patients with hip fractures over 65.

Integrated analysis of transcriptome and miRNAome reveals the heat stress response of Pinellia ternata seedlings.

Pinellia ternata (Thunb.) Briet., a valuable herb native to China, is susceptible to the "sprout tumble" phenomenon because of high temperatures, resulting in a significant yield reduction.

Assembly and comparative analysis of the complete mitochondrial genome of .

Pinellia ternata is an important natural medicinal herb in China. However, it is susceptible to withering when exposed to high temperatures during growth, which limits its tuber production. Mitochondria usually function in stress response.

Thyrotropin induces atherosclerosis by upregulating large conductance Ca-activated K channel subunits.

Hypothyroidism is associated with elevated levels of serum thyrotropin (TSH), which have been shown to promote abnormal proliferation of vascular smooth muscle cells and contribute to the development of atherosclerosis. However, the specific mechanisms underlying the TSH-induced abnormal proliferation of vascular smooth muscle cells remain unclear. The objective of this study was to investigate the role of TSH in the progression of atherosclerosis.

Unveiling the importance of VOCs from pesticides applicated in main crops for elevating ozone concentrations in China.

Volatile organic compounds (VOCs) are considered as important precursors of ozone in the air, while the contribution of VOCs from pesticide application (PVOCs) to ozone production is unknown. Utilizing data from the Ministry of Agriculture and Rural Affairs of the People's Republic of China and ChinaCropPhen1km, this paper developed PVOC emission inventories with a resolution of 1 km for the main crops (rice, maize, and wheat) from 2012 to 2019 in China. The results revealed that pesticide application is an important VOC emission source in China.

Risk prediction models for deep venous thrombosis in patients with acute stroke: A systematic review and meta-analysis.

Background: The number of risk prediction models for deep venous thrombosis (DVT) in patients with acute stroke is increasing, while the quality and applicability of these models in clinical practice and future research remain unknown.

Objective: To systematically review published studies on risk prediction models for DVT in patients with acute stroke.

Design: Systematic review and meta-analysis of observational studies.

Effectiveness of nonpharmacological multi-component intervention on depressive symptoms in patients with mild cognitive impairment and dementia: A systematic review and meta-analysis.

Patients with mild cognitive impairment (MCI) and dementia are more prone to depression than people without MCI or dementia. Some studies have found nonpharmacological multi-component intervention to be more effective than single-component intervention in improving the condition of patients with MCI and dementia; however, their effect on depressive symptoms is still inconsistent. Therefore, it is necessary to explore the effectiveness of nonpharmacological multi-component intervention in improving depressive symptoms in patients with MCI and dementia.

A method of gas-related pollution source layout based on multi-source data: A case study of shaanxi province, China.

The location and layout of enterprises have an important impact on local air quality. However, a few studies on exploring of the optimal layout of gas-related enterprises from the perspective of optimizing the layout of air pollution sources. This study developed a method for the evaluation of air pollution source layout based on air pollutant emission inventory data, atmospheric self-purification capacity data, and satellite remote sensing air quality data.

Transcriptome Analysis Reveals Long Non-Coding RNAs Involved in Shade-Induced Growth Promotion in .

Background: High temperature and drought environments are important limiting factors for growth, whereas shading can promote growth by relieving these stresses. However, the mechanism of growth promotion by shading in . is unknown.

A fluorescent probe based on modulation of ESIPT signaling for the highly selective detection of NH and cell-imaging.

The broad occurrence of the hydrazine (NH) residues in aqueousenvironment is a potential threat to human health. Currently, the mainstream strategy for designing NH-specific probes is to functionalize a fluorophore with nucleophilic sites for the reductionreaction with NH. In this work, we designed and synthesized an excited-state intermolecular proton transfer (inter-ESPT) fluorescent dye(2-amino-4-(4-methoxyphenyl)-7,8-dihydro-5H-spiro[quinoline-6,2'-[1,3]dioxolane]-3-carbonitrilem, DQN) and used it as a probe to sense NH.

Application of machine learning to predict hospital visits for respiratory diseases using meteorological and air pollution factors in Linyi, China.

Urbanization and industrial development have resulted in increased air pollution, which is concerning for public health. This study evaluates the effect of meteorological factors and air pollution on hospital visits for respiratory diseases (pneumonia, acute upper respiratory infections, and chronic lower respiratory diseases). The test dataset comprises meteorological parameters, air pollutant concentrations, and outpatient hospital visits for respiratory diseases in Linyi, China, from January 1, 2016 to August 20, 2022.

Theoretical investigation of the magnetic and optical properties in a transition metal-doped GaTeCl monolayer.

We investigate the structural, magnetic, electronic and optical properties of a transition metal-doped GaTeCl monolayer, denoted as M@GaTeCl (M = V, Cr, Mn, Fe and Co), by using first-principles calculations. It is found that the magnetic ground state can be regulated by different M elements. In the meantime, the electronic structure is different with the doping of different M metal atoms, and thus the optical absorption changes correspondingly.

A multi-block data approach to assessing beef quality: ComDim analysis of hyperspectral imaging, H NMR, electronic nose and quality parameters data.

Several factors affect the quality of beef. In the field of chemometrics, multi-block data analysis methods are useful for examining multiple sources of information from a sample. This study focuses on the application of ComDim, a multi-block data analysis method, to evaluate beef from different parts of hyperspectral spectrum and image texture information, H NMR fingerprints, quality parameters and electronic nose.