Unraveling the Degradation and Air-Induced Healing Mechanisms of Halide Perovskites under Proton Irradiation.

As exceptional potential candidates for future-generation space photovoltaics, perovskite solar cells (PSCs) have been proven to be radiation-tolerant and recoverable under proton irradiation. Nevertheless, a key point, the influence of the atmosphere, has often been overlooked in ground-based irradiation experiments. Here, the atmosphere-dependent radiation tolerance and healing of perovskite materials under MeV proton irradiation are demonstrated by utilizing in situ electrical characterizations.

Multimodal photoacoustic microscopy and optical coherence tomography ocular biomarker imaging in Alzheimer's disease in mice.

Alzheimer's disease (AD) is a neurodegenerative disease characterized by amyloid beta (Aβ)-containing extracellular plaques and tau-containing intracellular neurofibrillary tangles. Reliable and more accessible biomarkers along with associated imaging methods are essential for early diagnosis and to develop effective therapeutic interventions. Described here is an integrated photoacoustic microscopy (PAM) and optical coherence tomography (OCT) dual-modality imaging system for multiple ocular biomarker imaging in an AD mouse model.

A novel water-soluble NIR-II cyanine dye for fast targeted through-skull fluorescence imaging of orthotopic glioma.

A novel NIR-II cyanine dye denoted as Sulfo-1100 was designed and synthesized to realize high-fidelity imaging of orthotopic glioma. The dye in FBS (10%) and PBS showed NIR-I absorptions (866 nm and 776 nm, respectively) and NIR-II fluorescence emissions (1114 nm and 1120 nm). To realize specific imaging for orthotopic glioma , Sulfo-1100 was assembled with holo-Tf to form hT-Sulfo-1100 nanoparticles (NPs).

Extrachromosomal circular DNA and their roles in cancer progression.

Extrachromosomal circular DNA (eccDNA), a chromosome-independent circular DNA, has garnered significant attention due to its widespread distribution and intricate biogenesis in carcinoma. Existing research findings propose that multiple eccDNAs contribute to drug resistance in cancer treatments through complex and interrelated regulatory mechanisms. The unique structure and genetic properties of eccDNA increase tumor heterogeneity.

The Characterization of R2R3-MYB Genes in Water Lily Reveals the Involvement of NcMYB25 in Regulating Anthocyanin Synthesis.

, valued for its diverse flower colors and attractive shapes, is a popular ornamental aquatic plant. Anthocyanins provide color to flowers, and their biosynthesis is regulated by the R2R3-MYB transcription factor. In this study, we identified and analyzed the R2R3-MYB genes in , focusing on their structure, evolution, expression patterns, regulatory mechanisms, and biological functions.

Improving cabbage resistance to via crosses with .

Unlabelled: Cabbage is a widely cultivated leafy vegetable, but head rot disease caused by the fungus can seriously reduce its yield and quality. There are currently not any cabbage varieties that are completely immune to the disease, but its wild relative is very resistant. In this study, cabbage resistance was improved by backcrossing a highly resistant accession (C01) with a susceptible cabbage cultivar (F416).

Targeting erbB Pathways in Breast Cancer: Dual Kinase Inhibition for Brain Metastasis and Prevention of p185HER2/Neu Tumor Development.

Background: Breast cancer predominantly affects women and poses challenges in the treatment of both local and advanced diseases. In a previous study, we reported the effectiveness of ER121, a structurally resolved small compound specifically designed to target human cancers expressing or overexpressing mutant EGFR and HER2.

Purpose: The objective of this study is to assess the efficacy and toxicity of ER121 in metastatic and triple negative breast cancer (TNBC, HER2+) cells and tumor models.

Liquid biopsy with plasma Epstein-Barr virus DNA characterizes biological relapse for the prediction of cancer recurrence in non-disseminated nasopharyngeal carcinoma.

Purpose: To investigate whether a bounce in plasma Epstein-Barr virus (EBV) DNA during posttreatment surveillance of nasopharyngeal carcinoma (NPC) informs the risk of clinical recurrence and its implication for early therapeutic intervention.

Methods: 950 non-disseminated NPC patients with completed remission in 3 months after treatment were retrospectively screened. Detectable EBV DNA with no evidence of clinical relapse during follow-up was deemed as DNA bounce.

Processing Solid Hydrogels into Hollow Structures by Infrared Laser Light for Highly-Efficient Drug Loading and Controlled Release.

Hollow hydrogels, characterized by their three-dimensional networks akin to biological tissues, are extensively utilized in artificial blood vessels, drug delivery, and nerve conduits due to their superior biocompatibility and fluid-transportation capacity. Nonetheless, the fabrication of hollow hydrogels presents significant challenges, including intricate steps, costly equipment, and structural instability. Consequently, refining the preparation techniques for hollow hydrogels remains paramount to surmounting the limitations of conventional methods.

Synergistic effect of venetoclax and ibrutinib on ibrutinib-resistant ABC-type DLBCL cells.

Despite the widespread use of R-CHOP therapy in diffuse large B-cell lymphoma (DLBCL), the therapeutic efficacy for this disease remains suboptimal, primarily due to the heterogeneity of refractory and/or relapsed diseases. To address this challenge, optimization of DLBCL treatment regimens has focused on the strategy of combining an additional drug "X" with R-CHOP to enhance efficacy. However, the failure of R-CHOP combined with the BTK inhibitor ibrutinib in treating ABC-type DLBCL patients has raised significant concerns regarding ibrutinib resistance.

Neuroendoscopic surgery for brainstem hemorrhage: Technical notes and preliminary clinical results.

Background: Brainstem hemorrhage accounts for a relatively small proportion of spontaneous intracerebral hemorrhages (∼10 %) but tends to occur earlier in life and has poorer prognosis. Numerous studies support the therapeutic potential of minimally invasive hematoma evacuation for intracerebral hemorrhage; however, there have been few assessments of the benefits for brainstem hemorrhage.

Methods: We evaluated the safety and efficacy of a minimally invasive approach under neuroendoscopic guidance with pneumatic arm fixation for removing the hematoma in severe brainstem hemorrhage patients.

Adipose-Derived Stem-Cell-Membrane-Coated PLGA-PEI Nanoparticles Promote Wound Healing via Efficient Delivery of miR-21.

miRNAs have been shown to be involved in the regulation of a variety of physiological and pathological processes, but their use in the treatment of diseases is still limited due to their instability. Biomimetic nanomaterials combine nanomaterials with cellular components that are readily modifiable and biocompatible, making them an emerging miRNA delivery vehicle. In this study, adipose-derived MSC membranes were wrapped around PLGA-PEI loaded with miR-21 through co-extrusion and later transplanted into C57BL/6 mice wounds.

A Comparative Analysis of U-Net and Vision Transformer Architectures in Semi-Supervised Prostate Zonal Segmentation.

The precise segmentation of different regions of the prostate is crucial in the diagnosis and treatment of prostate-related diseases. However, the scarcity of labeled prostate data poses a challenge for the accurate segmentation of its different regions. We perform the segmentation of different regions of the prostate using U-Net- and Vision Transformer (ViT)-based architectures.