Determination and prediction of net energy of soybean meal fed to pregnant sows by indirect calorimetry.

Objective: The study was conducted to investigate the appropriate substitution level of soybean meal (SBM) for determining its net energy (NE), and establish NE prediction equation of SBM based on the determined NE values for pregnant sows.

Methods: In Exp. 1, eighteen pregnant sows (Landrace×Yorkshire; parity, 2 to 3) with an initial body weight (BW) of 221.

Multimodal abnormalities of brain function in chronic low back pain: a systematic review and meta-analysis of neuroimaging studies.

Objectives: Neuroimaging investigations into chronic low back pain (CLBP) have detected functional abnormalities across a spectrum of brain regions, yet the findings have often been inconsistent. In this meta-analysis, we integrated the existing data, delineating a pattern of coherent results from the encompassed studies.

Methods: A systematic search of neuroimaging studies investigating the brain activity differences between CLBP and Healthy controls (HCs) was conducted in seven databases up to December 22, 2024.

Enzymatic production of chitooligosaccharides with high degree of polymerisations and their potential application to soy sauce preservation.

Chitooligosaccharides (COSs) with a high degree of polymerisation (DP 5-10) have been reported to possess diverse bioactivities. Thus, the development of novel methods for the acquisition of high-DP COSs has become increasingly significant. In the study, a novel GH family 46 chitosanase gene (ThCsn46) was expressed and characterized.

Short-term probabilistic microcystin prediction using Bayesian model averaging.

We present a dynamic modeling approach for predicting the risk of high microcystin concentrations in Western Lake Erie. At the center of our model is an empirical model based on a basic mechanistic assumption about microcystin production in lakes (i.e.

Structural insights into transcription regulation of the global OmpR/PhoB family regulator PhoP from Mycobacterium tuberculosis.

As a global transcription activator or repressor, the representative OmpR/PhoB family response regulator PhoP plays a crucial role in regulating bacterial pathogenicity and stress adaptation. However, the molecular mechanisms underlying the transcriptional regulation that define its differential functions remain largely unclear. In the present study, we determine three cryo-EM structures of Mycobacterium tuberculosis (Mtb) PhoP-dependent transcription activation complexes (PhoP-TACs) and build one preliminary cryo-EM structure model of Mtb PhoP-dependent transcription repression complex (PhoP-TRC).

Research on intelligent routing with VAE-GAN in the internet of body.

The "Internet of Body" is an emerging technology that is centered on the human body and connected to the Internet. It can monitor a variety of human data (such as heart rate, blood oxygen content, etc.) and communicate with digital pills, wearable devices, etc.

TWIST1 Regulates FOXM1/β-Catenin to Promote the Growth, Migration, and Invasion of Ovarian Cancer Cells by Activating MFAP2.

TWIST1 is aberrantly expressed in ovarian cancer (OC). MFAP2 is a downstream target of TWIST1, and we previously found MFAP2 facilitated OC development by activating FOXM1/β-catenin. We planned to investigate the mechanisms of TWIST1 in OC.

Shear-Mediated Stabilization of Spin Spiral Order in Multiferroic NiI.

Type-II multiferroicity from non-collinear spin order is recently explored in the van der Waals material NiI. Despite the importance for improper ferroelectricity, the microscopic mechanism of the helimagnetic order remains poorly understood. Here, the magneto-structural phases of NiI are investigated using resonant magnetic X-ray scattering (RXS) and X-ray diffraction.

Transcutaneous electrical acupoint stimulation for upper limb spasticity after stroke: effect and feasibility-a randomised pilot study.

Importance: Limb spasticity is a common issue among stroke patients. Transcutaneous electrical acupoint stimulation (TEAS) is recommended as an alternative therapy for managing upper limb spasticity after stroke; however, its potential effects and feasibility remain uncertain.

Objective: To investigate the potential effects and feasibility of TEAS on motor function in patients with upper limb spasticity after stroke.

Sexually dimorphic dopaminergic circuits determine sex preference.

Sociosexual preference is critical for reproduction and survival. However, neural mechanisms encoding social decisions on sex preference remain unclear. In this study, we show that both male and female mice exhibit female preference but shift to male preference when facing survival threats; their preference is mediated by the dimorphic changes in the excitability of ventral tegmental area dopaminergic (VTA) neurons.

Active Vitamin D Ameliorates Arsenite-Induced Thyroid Dysfunction in Sprague-Dawley Rats by Inhibiting the Toll-like Receptor 4/NF-KappaB-Mediated Inflammatory Response.

Arsenic, a well-known environmental endocrine disruptor, exerts interference on the body's endocrine system. Our previous investigations have demonstrated that chronic exposure to sodium arsenite (NaAsO) can induce thyroid damage and dysfunction in Sprague-Dawley (SD) rats. Vitamin D (VD) is an indispensable fat-soluble vitamin that plays a crucial role in maintaining thyroid health.

A forecasting tool for optimized emission control strategies to achieve short-term air quality attainment.

Optimizing an emergency air pollution control strategy for haze events presents a significant challenge due to the extensive computational demands required to quantify the complex nonlinearity associated with controls on diverse air pollutants and regional sources. In this study, we developed a forecasting tool for emergency air pollution control strategies based on a predictive response surface model that quantifies PM responses to emission changes from different pollutants and regions. This tool is equipped to assess the effectiveness of emergency control measures corresponding to various air pollution alerts and to formulate an optimized control strategy aimed at specific PM targets.

[Advances in the application of comprehensive behavioral intervention in tic disorder].

Tic disorder is a neurodevelopmental disorder that occurs in children or adolescents, often attracting the attention of others due to involuntary, repetitive, and non-rhythmic tics, and drug therapy often causes negative emotions in children and their families due to its significant adverse reactions, poor compliance, and tendency of recurrence after drug withdrawal. In recent years, comprehensive behavioral intervention has shown great potential as a safe and effective treatment modality for tic disorders, with few adverse reactions. This article reviews the advances in the application of comprehensive behavioral intervention for tic disorder in China and abroad in the past 5 years, in order to provide a reference for clinical application.

Hepatic TM6SF2 activates antitumour immunity to suppress metabolic dysfunction-associated steatotic liver disease-related hepatocellular carcinoma and boosts immunotherapy.

Background: Transmembrane 6 superfamily member 2 (TM6SF2) has a protective role against metabolic dysfunction-associated steatotic liver disease (MASLD).

Objective: We aim to investigate the mechanistic role and therapeutic potential of hepatic TM6SF2 in MASLD-related hepatocellular carcinoma (HCC).

Design: Hepatocyte-specific knockout ( ) mice were fed with high-fat/high-cholesterol (HFHC) diet or diethylnitrosamine plus HFHC diet to induce MASLD-HCC.

Molecular disturbances and thyroid gland dysfunction in rats chronically exposed to a high dose of NaAsO₂: Insights from proteomic and phosphoproteomic analyses.

Arsenic is a ubiquitous hazardous metalloid that poses a significant threat to human health. Although researchers have investigated the detrimental effects of arsenic on the thyroid, a comprehensive exploration of its toxicological impact and underlying molecular mechanisms remains to be conducted. Both this study and our previous reports demonstrated that chronic exposure to sodium arsenite (NaAsO) results in histological impairment and dysfunction of the thyroid glands in Sprague-Dawley (SD) rats.

Regional transport characteristics of PM pollution events in Beijing during 2018-2021.

Although air pollutant emissions have sharply reduced in recent years, the occurrence of PM pollution events remains an intractable environmental problem in Beijing, and regional transport is the key influence factor. However, it has been difficult to identify regional transport characteristics and the main contributors to pollution events in recent years. In this study, the relative contribution of regional transport was quantified (61.

Impact of layoffs on mortality and physical health in transitional China 1989-2015.

This study examines the long-term health impacts of massive layoffs from State-Owned Enterprises (SOEs) in transitional China, a period characterized by significant economic, cultural, and policy transformation. Utilizing the China Health and Nutrition Survey data from 1989 to 2014, we employ a life course framework to analyze how macro and interpersonal contexts influence mortality and physical health following job loss. Our analysis reveals that, despite short-term income disruptions and persistent income volatility, laid-off workers restored income and gained improved access to various types of health insurance over two decades.

Multi-fusion strategy network-guided cancer subtypes discovering based on multi-omics data.

Introduction: The combination of next-generation sequencing technology and Cancer Genome Atlas (TCGA) data provides unprecedented opportunities for the discovery of cancer subtypes. Through comprehensive analysis and in-depth analysis of the genomic data of a large number of cancer patients, researchers can more accurately identify different cancer subtypes and reveal their molecular heterogeneity.

Methods: In this paper, we propose the SMMSN (Self-supervised Multi-fusion Strategy Network) model for the discovery of cancer subtypes.

SIFusion: Lightweight infrared and visible image fusion based on semantic injection.

The objective of image fusion is to integrate complementary features from source images to better cater to the needs of human and machine vision. However, existing image fusion algorithms predominantly focus on enhancing the visual appeal of the fused image for human perception, often neglecting their impact on subsequent high-level visual tasks, particularly the processing of semantic information. Moreover, these fusion methods that incorporate downstream tasks tend to be overly complex and computationally intensive, which is not conducive to practical applications.

Trimester-specific exposure to triclocarban during pregnancy: Associations with oxidative stress and size at birth.

Triclocarban (TCC) is an extensively used antimicrobial agent that exhibits endocrine disrupt potential, but its effects on fetal growth remain largely unknown. Herein, we measured TCC, its four hydroxylated metabolites and two dechlorination products, as well as the oxidative stress biomarker 8-hydroxy-2'-deoxyguanosine (8-OHdG) in maternal urine samples collected across three trimesters of pregnancy in Wuhan, China. Linear mixed-effect models and multiple linear regression models were applied for correlation analysis.

Psychometric Properties of Different Short Forms of Social Interaction Anxiety Scale in Chinese College Students.

Background: There exist four short forms of the Social Interaction Anxiety Scale (SIAS): 10-item version (SIAS-10), 6-item version by Peters et al (SIAS-6P), 6-item version by Fergus et al (SIAS-6F), and 5-item version (SIAS-5). This study aims to comprehensively examine the psychometric properties of the SIAS-10, SIAS-6P, SIAS-6F, and SIAS-5 and to determine which one performs relatively better in Chinese population.

Methods: This study enrolled 733 Chinese college students.