General (hetero)polyaryl amine synthesis via multicomponent cycloaromatization of amines.

(Hetero)polyaryl amines are extensively prevalent in pharmaceuticals, fine chemicals, and materials but the intricate and varied nature of their structures severely restricts their synthesis. Here, we present a selective multicomponent cycloaromatization of structurally and functionally diverse amine substrates for the general and modular synthesis of (hetero)polyaryl amines through copper(I)-catalysis. This strategy directly constructs a remarkable range of amino group-functionalized (hetero)polyaryl frameworks (194 examples), including naphthalene, binaphthalene, phenanthren, benzothiophene, dibenzothiophene, benzofuran, dibenzofuran, quinoline, isoquinoline, quinazoline, and others, which are challenging or impossible to obtain using alternative methods.

Exposure to polystyrene microplastics during lactational period alters immune status in both male mice and their offspring.

The widespread use of microplastics and their harmful effects on the environment have emerged as serious concerns. However, the effect of microplastics on the immune system of mammals, particularly their offspring, has received little attention. In this study, polystyrene microplastics (PS-MPs) were orally administered to male mice during lactation.

How do social and parasocial relationships on TikTok impact the well-being of university students? The roles of algorithm awareness and compulsive use.

Social media now has emerged as one of the most widely used communication channels. The objective of this work is to verify the factors that influence the compulsive use of TikTok, as well as the mediating role of algorithm awareness, and to identify the predictors of well-being related to the use of TikTok. In the present work, the relevance of the study of PSRs and FoMO that affect the compulsive use of TikTok in young people is discussed.

FGF19-Based Mini Probe Targeting FGFR4 for Diagnosis and Surgical Navigation of Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is a frequent malignancy that has a high death rate and a high rate of recurrence following surgery, owing to insufficient surgical resection. Furthermore, HCC is prone to peritoneal metastasis (HCC-PM), resulting in a significant number of tiny cancer lesions, making surgical removal more challenging. As a potential imaging target, FGFR4 is highly expressed in tumors, especially in HCC, but is less expressed in the normal liver.

Transcriptome Profiling of Male Adult .

Background: The pathogen of angiostrongyliasis is the parasite and the transcriptome profiling of the male adult was unclear. We aimed to understand how the male adults adapt, so the expression profile of adult males was analyzed.

Methods: In order to improve the understanding of the transcriptome of adult males, RNA from three groups of male adult was extracted and reverse transcribed to construct cDNA libraries.

"Guess You Like It" - How personalized recommendation timing and product type influence consumers' acceptance: An ERP study.

Personalized recommendation has been increasingly used in online shopping environment, and improving the effectiveness of personalized recommendation is an important issue. On the basis of two-stage decision theory and preference inconsistency theory, our study adopted the neuroscientific methodology of event-related potential to investigate the decision-making process and psychological mechanism of consumers for personalized recommendation under different recommendation timings (browsing and decision stages) and recommended product types (similar and related). Behavioral results showed that consumers' acceptance of similar product recommendations was higher than that of related product recommendations during the browsing stage, whereas no difference was observed in consumers' acceptance of the two product types during the decision stage.

Effects of Background Fitting of e-Commerce Live Streaming on Consumers' Purchase Intentions: A Cognitive-Affective Perspective.

Purpose: The purpose of this paper is to explore the effects of the background fitting of e-commerce live streaming on consumers' purchase intentions and the relevant internal psychological mechanism from the cognitive-affective perspective.

Methods: In this study, a theoretical framework model of SOR comprising six variables is established. SPSS and SmartPLS are used to test the model and analyze data collected from a comprehensive questionnaire survey of 424 Chinese online consumers.

Integrative genomics analysis of the ever-shrinking pectin methylesterase (PME) gene family in foxtail millet ().

Pectin methylesterase (PME) plays a vital role in the growth and development of plants. Their genes can be classified into two types, with Type-1 having an extra domain, PMEI. PME genes in foxtail millet (Setaria italica L.

CFVisual: an interactive desktop platform for drawing gene structure and protein architecture.

Background: When researchers perform gene family analysis, they often analyze the structural characteristics of the gene, such as the distribution of introns and exons. At the same time, characteristic structural analysis of amino acid sequence is also essential, for example, motif and domain features. Researchers often integrate these analyses into one image to dig out more information, but the tools responsible for this integration are lacking.

Dioscin exhibits protective effects on in vivo and in vitro asthma models via suppressing TGF-β1/Smad2/3 and AKT pathways.

Dioscin is a natural product that possesses protective effects on multiple chronic injuries, but its effects on asthma are not fully understood. Herein, we evaluated its effects on asthmatic mice established by ovalbumin (OVA) sensitization and challenges and further explored the mechanism. Inflammatory cells in bronchoalveolar lavage fluids (BALFs) were analyzed using Diff-Quik staining.

Cu(i) catalysis for selective condensation/bicycloaromatization of two different arylalkynes: direct and general construction of functionalized C-N axial biaryl compounds.

Selective condensation/bicycloaromatization of two different arylalkynes is firstly developed under ligand-free copper(i)-catalysis, which allows the direct synthesis of C-N axial biaryl compounds in high yields with excellent selectivity and functional group tolerance. Due to the critical effects of Cu(i) catalyst and HFIP, many easily occurring undesired reactions are suppressed, and the coupled five-six aromatic rings are constructed the selective formation of two C(sp)-N(sp) bonds and four C(sp)-C(sp) bonds. The achievement of moderate enantioselectivity verifies its potential for the simplest asymmetric synthesis of atropoisomeric biaryls.

Filter-membrane treatment of flowing antibiotic-containing wastewater through peroxydisulfate-coupled photocatalysis to reduce resistance gene and microbial inhibition during biological treatment.

The direct biological treatment of antibiotics containing wastewater brings about a potential risk of antibiotic resistance genes (ARGs) spread. Although advanced oxidation technologies based on photocatalysis generally appear effective at degrading antibiotics in wastewater, the fate of ARGs in succeeding biological treatment system is still unknown. Herein, a filter-membrane-like carbon cloth-immobilized FeO/g-CN photocatalyst is fabricated through immersion-calcination method.

pyDRMetrics - A Python toolkit for dimensionality reduction quality assessment.

High-dimensional data are pervasive in this bigdata era. To avoid the curse of the dimensionality problem, various dimensionality reduction (DR) algorithms have been proposed. To facilitate systematic DR quality comparison and assessment, this paper reviews related metrics and develops an open-source Python package pyDRMetrics.

Highly efficient oxidative-alkaline-leaching process of vanadium-chromium reducing residue and parameters optimization by response surface methodology.

Vanadium-chromium reducing residue was not only a typical solid waste in the steel industry but also a valuable secondary source for recovery of vanadium and chromium. A highly efficient oxidative-alkaline-leaching technology with NaSO was applied in this work. The effect of experimental factors including m(NaOH)/m(Residue), liquid-to-solid ratio, reaction temperature, m(NaSO)/m(Residue) and reaction time, on the leaching process were investigated.

Differential Effects of Monetary and Social Rewards on Product Online Rating Decisions in E-Commerce in China.

Humans can change their behaviors to obtain environmental rewards (e.g., money, food, and sex).

Oxidative Leaching Kinetics of Vanadium from the Vanadium-Chromium-Reducing Residue with KCrO.

Oxidative-alkaline leaching of vanadium from vanadium-chromium-reducing residues with KCrO was investigated in this paper. The effects of processing parameters including dosage of NaOH, dosage of KCrO, reaction time, and reaction temperature on the leaching efficiency of vanadium were studied. The results simulated by response surface methodology indicated that vanadium leaching was affected significantly by the dosage of KCrO and NaOH, and the processing parameters that affected the leaching efficiency of vanadium followed the order (NaOH)/(residue) > (KCrO)/sssss(residue) > reaction temperature > reaction time.

Step-Adsorption of Vanadium (V) and Chromium (VI) in the Leaching Solution with Melamine.

The vanadium (V) and chromium (VI) was hard to separate directly due to the similar nature. In this paper, separation and recovery of vanadium (V) and chromium (VI) from a leaching solution was investigated by adsorption of vanadium (V) with melamine, followed by electro-reduction of chromium (VI) and adsorption of chromium (III) with melamine, respectively. The effects of experimental parameters including dosage of melamine, reaction temperature and reaction time on the adsorption process were investigated.

Low-Order Webpage Layout in Online Shopping Facilitates Purchase Decisions: Evidence from Event-Related Potentials.

Introduction: In online shopping, the webpage layout plays an important part in the consumer's experience. The present study aims to investigate whether the webpage order and which order level (high order vs low order) facilitate consumers' instant purchase decisions for products.

Methods: Fourteen right-handed healthy undergraduates and graduate students participated in the experiment as paid participants.

General Oxidative Aryl C-P Bond Formation through Palladium-Catalyzed Decarbonylative Coupling of Aroylhydrazides with P(O)H Compounds.

Oxidative C-C/P-H cross-coupling is achieved via Pd-catalyzed decarbonylative cross-coupling of aroylhydrazides with P(O)H compounds. The unique cooperative reaction system, especially the Brønsted acid and bidentate phosphine ligand, allows the selective activation of the inert C-C bond and the suppression of the undesired oxidation and coordination of >P(O)-H compounds, leading to a general oxidative synthesis of aryl phosphorus compounds from easily available substrates.