Measurement of Λ_{b}^{0}, Λ_{c}^{+}, and Λ Decay Parameters Using Λ_{b}^{0}→Λ_{c}^{+}h^{-} Decays.

A comprehensive study of the angular distributions in the bottom-baryon decays Λ_{b}^{0}→Λ_{c}^{+}h^{-}(h=π,K), followed by Λ_{c}^{+}→Λh^{+} with Λ→pπ^{-} or Λ_{c}^{+}→pK_{S}^{0} decays, is performed using a data sample of proton-proton collisions corresponding to an integrated luminosity of 9  fb^{-1} collected by the LHCb experiment at center-of-mass energies of 7, 8, and 13 TeV. The decay parameters and the associated charge-parity (CP) asymmetries are measured, with no significant CP violation observed. For the first time, the Λ_{b}^{0}→Λ_{c}^{+}h^{-} decay parameters are measured.

aPD-L1-facilitated theranostic and tumor microenvironment remodeling of pancreatic cancer via docetaxel-loaded phase-transformation nanoparticles triggered by low-intensity pulsed ultrasound.

Early diagnosis of pancreatic ductal adenocarcinoma (PDAC) is challenging because of its depth, which often leads to misdiagnosis during ultrasound examinations. The unique PDAC tumor microenvironment (TME) is characterized by significant fibrous tissue growth, and high interstitial pressure hinders drug penetration into tumors. Additionally, hypoxia and immune suppression within the tumor contribute to poor responses to radiotherapy and chemotherapy, ultimately leading to an unfavorable prognosis.

Emerging Physics in Magnetic Organic-Inorganic Hybrid Systems.

The hybrid magnetic heterostructures and superlattices, composed of organic and inorganic materials, have shown great potential for quantum computing and next-generation information technology. Organic materials generally possess designable structural motifs and versatile optical, electronic, and magnetic properties, but are too delicate for robust integration into solid-state devices. In contrast, inorganic systems provide robust solid-state interface and excellent electronic properties but with limited customization space.

Polylactic acid microplastics before and after aging induced neurotoxicity in zebrafish by disrupting the microbiota-gut-brain axis.

Polylactic acid (PLA) is a biodegradable alternative to traditional plastics due to its excellent biocompatibility. However, PLA is challenging to fully degrade and can easily become microplastics (MPs) in surface water, a process accompanied by aging. This study found that aged PLA (APLA) MPs exhibited increased surface roughness, decreased surface potential, and more oxygen-containing functional groups compared to PLA.

Tuning the Acid Hardness Nature of Cu Catalyst for Selective Nitrate-to-Ammonia Electroreduction.

Electrocatalytic nitrate reduction reaction (NO3RR) in alkaline electrolyte presents a sustainable pathway for energy storage and green ammonia (NH3) synthesis. However, it remains challenging to obtain high activity and selectivity due to the limited protonation and/or desorption processes of key intermediates. Herein, we propose a strategy to regulate the acid hardness nature of Cu catalyst by introducing appropriate modifier.

Retinal vascular geometry and its association to silent brain infarction.

Objective: To examine the relationship between retinal vascular geometry and silent brain infarction (SBI) in the Chinese population.

Methods: We conducted a cross-sectional study that retrospectively analyzed the fundus photographs, MRI and other clinical data of 227 SBIs and 227 controls who visited Shanghai Health And Medical Center for physical examination. The retinal vessel fractal dimension (FD), retinal artery fractal dimension (FDa), retinal vein fractal dimension (FDv), central retinal artery diameter in the region from 0.

Cola beverage reduces risk of lead poisoning from accidental ingestion of contaminated soil particles in rat and swine models.

Accidental ingestion of lead (Pb)-contaminated soils represents a major route of Pb exposure for both adults and children, and the development of accessible and cost-effective solutions to reduce Pb poisoning is urgently required. Here, we present an effective and straightforward technique, involving the consumption of cola beverages, for the purpose of lowering blood Pb levels following the ingestion of contaminated soils in animal models. This method facilitated the direct passage of Pb in contaminated soil through the digestive system, enhancing its elimination without absorption into systemic circulation.

Clinical events associated with poor CD4 T-cell recovery in people living with HIV following ART: A systematic review and meta-analysis.

Background: Antiretroviral therapy (ART) has significantly improved outcomes for people living with HIV (PLWH), but poor CD4 T-cell recovery remains a challenge. This study aimed to evaluate the relationship between poor CD4 T-cell recovery and the morbidity of clinical events (CEs) in PLWH after ART initiation.

Methods: We conducted a comprehensive search of the EMBASE, PubMed, Web of Science, and Cochrane Library databases up to February 19, 2024, and included studies that reported the number of CEs along with the CD4 count at the time of the CEs or the most recent CD4 count prior to the CEs.

Ultra-high electrostriction and ferroelectricity in poly (vinylidene fluoride) by 'printing of charge' throughout the film.

Electrostriction is an important electro-mechanical property in poly (vinylidene fluoride) (PVDF) films, which describes the proportional relation between the electro-stimulated deformation and the square of the electric field. Generally, traditional methods to improve the electrostriction of PVDF either sacrifice other crystalline-related key properties or only influence minimal regions around the surface. Here, we design a unique electret structure to fully exploit the benefits of internal crystal in PVDF films.

Benzenedialdehyde-crosslinked gelatin nanoparticles for Pickering emulsion stabilization.

In this work, three types of benzenedialdehydes (1,2-, 1,3-, and 1,4-BDAs) were used to prepare BDA-crosslinked gelatin nanoparticles and the 1,2-BDA-crosslinked gelatin nanoparticle was explored to stabilize fish oil-loaded Pickering emulsions. The nanoparticle preparation was dependent on both pH and crosslinker types. 1,2-BDA and preparation pH of 12.

Feasibility, Acceptability, and Preliminary Efficacy of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Adolescents in China: A Pilot Study.

Currently, there is a lack of cost-effective and accessible intervention resources for Chinese adolescents with emotional disorders. The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Adolescents (UP-A), which aims to apply transdiagnostic treatment principles to target core dysfunctions across a range of emotional disorders with a single protocol, could fill this gap. We first modified the UP-A for use in the Chinese cultural context and then assessed its feasibility, acceptability, and preliminary efficacy using a single-arm design.

Myristoylated Eepd1 Enhances Lipolysis and Thermogenesis through PKA Activation to Combat Obesity.

Middle-aged obesity, characterized by excessive fat accumulation and systemic energy imbalance, often precedes various health complications. Recent research has unveiled a surprising link between DNA damage response and energy metabolism. Here, we explore the role of Eepd1, a DNA repair enzyme, in regulating adipose tissue function and obesity onset.

Targeted Analysis of VOCS in Exhaled Breath of Coal Workers' Pneumoconiosis Patients, An Exploratory Study.

Introduction: Pneumoconiosis represents the most prevalent occupational disease in China, with coal workers' pneumoconiosis (CWP) showing the highest incidence. Analysis of volatile organic compounds (VOCs) in the exhaled breath of CWP patients may provide novel insights into its pathogenesis.

Methods: Study data were collected through questionnaires and medical examinations.

Coal Worker's Pneumoconiosis-Targeted Lipidomics Reveals Aberrant Phospholipid Metabolism for Early-Stage Diagnosis.

Introduction: Pneumoconiosis is the most prevalent occupational disease in China, with coal worker pneumoconiosis (CWP) demonstrating the highest incidence. Studies have indicated that phospholipids may be associated with CWP.

Methods: In this study, serum was obtained from 62 patients with pneumoconiosis, 105 coal dust-exposed workers, and 50 healthy individuals and analyzed via targeted lipidomics using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).

Efficacy of internet-based cognitive behavioral therapy for medicated adults with attention-deficit/hyperactivity disorder (ADHD): A randomized controlled trial.

Background: Cognitive behavioral therapy (CBT) is an effective treatment for adults with attention-deficit/hyperactivity disorder (ADHD), but its use is limited by poor accessibility and time constraints-barriers that internet-based CBT (iCBT) may help overcome. This trial aimed to explore the short- and long-term efficacy of iCBT in medicated adults with ADHD.

Methods: Eighty-six adults with ADHD were randomized into two groups: the iCBT combined with medication group (iCBT+M, n = 43) and the medication-only group (n = 43).

Enhancing CO Electroreduction to Multicarbon Products by Modulating the Surface Microenvironment of Electrode with Polyethylene Glycol.

Modulating the surface microenvironment of electrodes stands as a pivotal aspect in enhancing the electrocatalytic performance for CO electroreduction. Herein, we propose an innovative approach by incorporating a small amount of linear oligomer, polyethylene glycol (PEG), into CuO catalysts during the preparation of the Cu electrode. The Faradaic efficiency (FE) toward multicarbon products (C) increases from 69.

The MYB61-STRONG2 module regulates culm diameter and lodging resistance in rice.

Lodging reduces grain yield and quality in cereal crops. Lodging resistance is affected by the strength of the culm, which is influenced by the culm diameter, culm wall thickness, and cell wall composition. To explore the genetic architecture of culm diameter in rice (Oryza sativa), we conducted a genome-wide association study (GWAS).

A nested case-control study on the effect of sarcopenia on mild cognitive impairment using the CHARLS database.

Objective: This study aimed to assess the influence of sarcopenia on mild cognitive impairment (MCI) through a nationally representative survey.

Method: Participants in this nested case-control study were from the China Health and Retirement Longitudinal Study (CHARLS) cohort. In 2015, 3222 participants were included, with 2304 participants were followed up in 2018.

OsNCED5 confers cold stress tolerance through regulating ROS homeostasis in rice.

Cold stress is one of the most serious abiotic stresses that affects the growth and yield in rice. However, the molecular mechanism by which abscisic acid (ABA) regulates plant cold stress tolerance is not yet clear. In this study, we identified a member of the OsNCED (9-cis-epoxycarotenoid dioxygenase) gene family, OsNCED5, which confers cold stress tolerance in rice.

The Developments and Prospects of Plant Super Pangenomes: Demands, Approaches and Applications.

By integrating genomes of different accessions, the pangenome can offer more comprehensive and reference-bias-free population genetic information in a species than a single reference genome. With the rapid accumulation of genomic sequencing data and the expanding scope of plant research, the focus of plant pangenomics research has gradually evolved from a single species to multiple species in recent years, giving rise to the concept of super pangenome that cover all genomic sequences of a genus-level taxonomic groups. By integrating more cultivated and wild species, the super pangenome has made significant contributions to the resolution of multiple research areas such as plant genetic diversity, evolution, domestication, and molecular breeding.

Natural variation in an HD-ZIP factor identifies its role in controlling apple leaf cuticular wax deposition.

Natural variation is an invaluable genetic resource for plant trait improvement. Here, we performed a genome-wide association study (GWAS) analysis and identified MdHDG5, which controls apple leaf cuticular wax. An A-to-G single-nucleotide polymorphism (SNP) on the HDG5 promoter is associated with HDG5 expression and hexacosanol content (a component of leaf cuticular wax).