Circulating plasma derived exosomes from systemic lupus erythematosus aggravate lupus nephritis through miR-122-5p/FOXO3-mediated macrophage activation.

Systemic lupus erythematosus (SLE) is a chronic and systemic autoimmune disease characterized by dysregulation in both innate and adaptive immunity. Polarization of macrophages into M1/M2 macrophages affects the development of lupus. Exosomes-miRNA plays a crucial role in disease progression.

Disease burden and health inequality of older adults with edentulism and the projected trend until 2040: based on the global burden of disease study 2021.

Objectives: To comprehensively analyze the current situation and the trends over the next 21 years, focusing on health inequalities related to edentulism among the elderly across global regions.

Materials And Methods: Data on edentulism in older adults were collected from the 2021 global burden of disease (GBD) study. Disease burden trends were analyzed using a joinpoint model.

Excessive Daytime Sleepiness as a Risk Factor for Impulse Control Disorders in Parkinson's Disease.

Purpose: Impulse control disorders (ICDs) and excessive daytime sleepiness (EDS) are common symptoms in Parkinson's disease (PD). Few longitudinal studies have focused on the association between EDS and ICDs. This longitudinal study aimed at assessing association between EDS and ICDs in PD.

Prediction model of stock return on investment based on hybrid DNN and TabNet model.

With the development of the social economy, research on stock market prediction is in full swing. However, the fluctuations in stock price and returns are influenced by many factors, including political policies, market environment, investor psychology, and so on. The traditional analysis method, based on subjective experience, requires significant time and effort, and its prediction accuracy is often poor.

Mechanism study of the effect of copper ions on the stability of As(III) sulfuration precipitation in acidic copper smelting wastewater.

Sulfide precipitation is considered as a very efficient method for removing arsenic from actual copper smelting acidic wastewater. However, the arsenic removal process can be affected by copper ions. This study focuses on the mechanism of copper ions' influence on the stability of As(III) sulfuration precipitation.

Comprehensive characterization of neddylation related genes in cutaneous melanoma identified a novel prognostic signature for treatment outcomes, immune landscape.

Neddylation, as a post-translational modification, has garnered significant attention in various tumor types recently. Few studies have investigated the involvement of neddylation-related genes (NRGs) in cutaneous melanoma (CM). Our study aims to identify prognostic NRGs and investigate their potential roles in CM.

Effect of high amylose starch on the incorporation of thymol into electrospun pullulan nanofibers.

High amylose starch (HAMS) was employed as an effective carrier to incorporate thymol within pullulan nanofibers. Aqueous solutions with HAMS concentrations of 0 % - 5 % were investigated to study their effect on the incorporation of thymol during electrospinning. As a result, the loading capacity was significantly improved by the addition of HAMS, increasing from 2.

Modulating the local electron density at built-in interface iron single sites in Fe-CN/MoO heterostructure for enhanced CO reduction to CH and photo-Fenton reaction.

The catalytic efficiency of heterogeneous photocatalytic CO reduction and photo-Fenton HO activationisclosely related to the local electron density of reaction center atoms. However, electron-hole recombination from random charge transfer significantly restricts the targeted electron delivery to the active center. Herein, Fe-CN/MoO heterojunction with interfacial coordination of atomically dispersed Fe-N sites with the O interface of MoO was synthesized by simple hydrothermal method.

Deciphering the Therapeutic Efficacy and Underlying Mechanisms of Polysaccharides in the Intervention of Alzheimer's Disease Mice: Insights from Metabolomics and Microbiome.

As a traditional drug-food homologous plant, is widely recognized for its nutritional and medicinal value. Specifically, polysaccharide (DOP) has garnered attention as a potential prebiotic for its protective effects on gut microbiota and the nervous system. However, the underlying mechanism by which DOP improves cognitive dysfunction in Alzheimer's disease (AD) remains unclear.

Evaluating AGS efficiency in PHA synthesis and extraction integrated with nutrient removal: The impact of COD concentrations.

As natural and biodegradable biopolymers, Polyhydroxyalkanoates (PHA) were synthetized by aerobic granules sludge (AGS) in a sequential batch reactor in this study. The effect of different COD concentrations on PHA accumulation and nutrients removal were investigated. At the same time, different pretreatment methods for PHA extraction, including NaClO pretreatment for extracellular polymeric substances (EPS) removal, NaCO pretreatment for EPS recovery, and grinding pretreatment to reduce particle size and augment the surface area available for interaction with the extraction solvent, were compared.

Neutrophil Extracellular Traps Participate in the Pathogenesis of Lupus Through S100A10-Mediated Regulatory T-Cell Differentiation and Functional Abnormalities.

In systemic lupus erythematosus (SLE), neutrophil dysregulation and neutrophil extracellular traps (NETs) formation contribute to disease pathogenesis, potentially worsening the autoimmune response. Although research indicates NETs' involvement in various autoimmune conditions, their relationship with regulatory T cells (Tregs) in SLE remains elusive. In this study, in vivo experiments were involved in administering NET injections to C57BL/6 and MRL/Ipr mice.

Development and validation of a droplet digital PCR method for quantifying lentiviral vector infectious titer.

Lentiviruses, with their high transduction efficiency and gene expression levels, are widely used as gene delivery vectors in the development of chimeric antigen receptor T cells (CAR-T) and other genetically modified cell therapies. Accurate determination of the lentiviral vector infectious titer is essential to ensure effective transduction and product consistency. In this study, we developed an efficient method for lentiviral vector titration based on digital droplet polymerase chain reaction (ddPCR) technology, enabling absolute quantification of the target gene.

Preventing and treating neurotrophic keratopathy by a single intrastromal injection of AAV-mediated gene therapy.

Purpose: Neurotrophic keratopathy (NK) is a degenerative corneal condition resulting from corneal nerve injury. Current therapies, including the recombinant human nerve growth factor (rhNGF) therapy, requires continuous administration. This study aims to develop a novel and highly effective gene therapy strategy for the prevention and treatment of NK.

Multi-Scale Meteorological Impact on PM Pollution in Tangshan, Northern China.

Tangshan, a major industrial and agricultural center in northern China, frequently experiences significant PM pollution events during winter, impacting its large population. These pollution episodes are influenced by multi-scale meteorological processes, though the complex mechanisms remain not fully understood. This study integrates surface PM concentration data, ground-based and upper-air meteorological observations, and ERA5 reanalysis data from 2015 to 2019 to explore the interactions between local planetary boundary layer (PBL) structures and large-scale atmospheric processes driving PM pollution in Tangshan.

VHL synthetic lethality screens uncover CBF-β as a negative regulator of STING.

Clear cell renal cell carcinoma (ccRCC) represents the most common form of kidney cancer and is typified by biallelic inactivation of the von Hippel-Lindau () tumour suppressor gene. Here, we undertake genome-wide CRISPR/Cas9 screening to reveal synthetic lethal interactors of , and uncover that loss of Core Binding Factor β (CBF-β) causes cell death in -null ccRCC cell lines and impairs tumour establishment and growth . This synthetic relationship is independent of the elevated activity of hypoxia inducible factors (HIFs) in -null cells, but does involve the RUNX transcription factors that are known binding partners of CBF-β.

Myosteatosis and the clinical outcomes of patients with liver cirrhosis: A meta-analysis.

Objectives: This study aimed to examine the potential correlation between myosteatosis and the prognosis of patients diagnosed with liver cirrhosis by a meta-analysis.

Methods: Cohort studies of relevance were acquired through comprehensive searches of the Medline, Web of Science, and Embase databases. To account for heterogeneity, a random-effects model was employed to combine the findings.

Relationship between internal structure and in vitro digestibility of A- and B-type wheat starch revealed by chemical surface gelatinization.

In this study, the properties of remaining starch granules obtained with different degrees of exfoliation were explored by removing the outer layers of A- and B-type wheat starch (AWS and BWS) granules with chemical surface gelatinization. SEM images revealed significant morphological variations with increasing exfoliation. CLSM and amylose content analysis indicated a predominance of lipid complexes in the outer granule layers, particularly in BWS.

Rupr. roots: a comprehensive review of botany, traditional uses, phytochemistry, pharmacology, quality control, and toxicology.

Rupr. is a traditional herb generally distributed in most areas of China, north Korea and Japan. The dried roots of Rupr.

Effects of home-based telemedicine and mHealth interventions on blood pressure in stroke patients: a systematic evaluation and meta-analysis of randomized controlled trials.

Background: Stroke is a common cerebrovascular disease. Elevated blood pressure is the most significant manageable factor for both initial and recurrent strokes. Despite the potential benefits of telemedicine and mobile health technology (mHealth) in managing blood pressure among stroke patients, there remains skepticism.

Global burden, risk factor analysis, and prediction study of leukaemia from 1990 to 2030.

Background: Leukaemia is a devastating disease with an incidence that progressively increases with advancing age. The World Health Organization has designated 2021-30 as the decade of healthy ageing, highlighting the need to address age-related diseases. We estimated the disease burden of leukaemia and forecasted it by 2030.

Engineered Mitochondrial Transplantation as An Anti-Aging Therapy.

Aging is an inevitable and complex biological process involving multi-factorial mechanisms. Mitochondrial dysfunction is a critical factor in the aging process, characterized by a decline in mitochondrial quality and activity, leading to aging and aging-related diseases. Therefore, mitochondria have become an attractive target in anti-aging therapies.