Publications by authors named "Qian He"

Systemic lupus erythematosus (SLE) is a chronic and systemic autoimmune disease characterized by dysregulation in both innate and adaptive immunity. Polarization of macrophages into M1/M2 macrophages affects the development of lupus. Exosomes-miRNA plays a crucial role in disease progression.

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Background: The assessment of lung adenocarcinoma significantly depends on the proportion of solid components in lung nodules. Traditional one-dimensional consolidation tumor ratio (1D CTR) based on ideal, uniformly dense solid components lacks precision. There is no consensus on the CT threshold for evaluating invasiveness using the threshold segmentation method.

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Large yellow croaker (Larimichthys crocea) has been demonstrated to be divided into three geographical stocks from south to north along the coast of China, including Nanhai, Mindong, and Daiqu. Although multiple versions of L. crocea have been published, no high-quality Nanhai and Daiqu genomes have been assembled, hampering the assessment of the fine-scale genetic structure and adversely affecting wild stock conservation, fishery management, and germplasm exploitation of large yellow croaker.

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Pulmonary mucormycosis is a rare and aggressive invasive fungal infection that predominantly affects immunocompromised individuals, such as those with diabetes mellitus or those undergoing immunosuppressive therapy. This case describes a severe instance of pulmonary mucormycosis resulting in progressive tracheal wall destruction in a young, previously healthy male. A 20-year-old male with a denied history of diabetes mellitus was admitted to a local hospital with abdominal pain for 9 days and diagnosed with acute pancreatitis and diabetic ketoacidosis (DKA).

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Gastric cancer (GC) is one of the common malignant tumors, and most patients with advanced GC often develop chemotherapy resistance, resulting in poor chemotherapy efficacy. Therefore, it is crucial to clarify the specific mechanisms of their chemotherapy resistance. In this study, we analyzed the correlation between fos-related antigen-1 (Fra-1) and chemotherapy resistance in GC using bioinformatics, cell counting kit-8 (CCK8), and 5-ethynyl-2'-deoxyuridine (EDU) combined with flow cytometry; furthermore, we used energy metabolomics sequencing, combined with ChIP-qPCR technology, to elucidate the specific role of Fra-1 in chemotherapy resistance of GC cells and its related mechanisms.

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Concerns over food safety arising from conventional plastic and resin-based corrosion barriers cannot be underestimated, particularly in light of the potential for plasticizer migration. We introduce an environmental-friendly and sustainable approach to develop superhydrophobic and anticorrosion coatings. This involved a unique process where glutenin, post-reduction with tris(2-carboxyethyl)phosphine, underwent a phase transition, naturally adhering to diverse surfaces to form a foundational primer.

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Lung cancer is the leading cause of cancer-related fatalities globally, related to inflammatory and gut microbiota imbalance. L. polysaccharide (BP) is a functional compound, which is utilized by the gut microbiota to regulate immunity and metabolism.

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The diazidation of alkenes through an iron-catalyzed, ligand-free system has been established, providing straightforward access to structurally vicinal diazides in good yields at room temperature with TMSN as the azido source. The ratio of BuOOH to TMSN was essential for the reaction: one equivalent TMSN was needed to react with BuOOH to form HN as a nucleophile in the reaction ultimately achieving the diazidation of alkenes.

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Orbital angular momentum (OAM) beams have demonstrated significant potential in the fields of communication, imaging and quantum information science. In particular, active OAM metasurfaces enable flexible and on-demand control of OAM beams without altering their structures, significantly enriching the applications of OAM beams. However, due to the limitations of electrode wiring and unit structure efficiency, most existing active metasurface designs are reflective, hindering the further development of this field.

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In-sensor computing, which integrates sensing, memory and processing functions, has shown substantial potential in artificial vision systems. However, large-scale monolithic integration of in-sensor computing based on emerging devices with complementary metal-oxide-semiconductor (CMOS) circuits remains challenging, lacking functional demonstrations at the hardware level. Here we report a fully integrated 1-kb array with 128 × 8 one-transistor one-optoelectronic memristor (OEM) cells and silicon CMOS circuits, which features configurable multi-mode functionality encompassing three different modes of electronic memristor, dynamic OEM and non-volatile OEM (NV-OEM).

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Neurodevelopmental abnormalities are considered to be one of the important causes of schizophrenia. The offspring of methylazoxymethanol acetate (MAM)-exposed mice are recognized for the dysregulation of neurodevelopment and are well-characterized with schizophrenia-like phenotypes. However, the inhibition-related properties of the medial prefrontal cortex (mPFC) and hippocampus throughout adolescence and adulthood have not been systematically elucidated.

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Background: With the rising incidence of pulmonary nodules (PNs), lung adenocarcinoma in situ (AIS) is a critical early stage of lung cancer, necessitating accurate diagnosis for early intervention. This study applies artificial intelligence (AI) for quantitative imaging analysis to differentiate AIS from atypical adenomatous hyperplasia (AAH) and minimally invasive adenocarcinoma (MIA), aiming to enhance clinical diagnosis and prevent misdiagnosis.

Methods: The study analyzed 1215 PNs with confirmed AAH, AIS, and MIA from six centers using the Shukun AI diagnostic module.

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Background: Primary pulmonary diffuse large B-cell lymphoma (PP-DLBCL) is a rare extranodal non-Hodgkin's lymphoma (EN-NHL). Its prognosis as an aggressive lymphoma is abysmal, and predictive models are still lacking.

Methods: We screened patients diagnosed with PP-DLBCL between 2010 and 2019 from the Surveillance, Epidemiology, and End Results (SEER) database.

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Nociceptors, crucial sensory receptors within biological systems, are essential for survival in diverse and potentially hazardous environments. Efforts to replicate nociceptors through advanced electronic devices, such as memristors and neuromorphic transistors, have achieved limited success, capturing basic nociceptive functions while more advanced characteristics like various forms of central sensitization and analgesic effect remain out of reach. Here, we introduce a vertical multigate, multichannel electrolyte-gated transistor (Vm-EGT), designed to mimic nociceptors.

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Injectable hydrogels, which are polymeric materials that are characterized by their ability to be injected in a liquid form into cavities and subsequently undergo in situ solidification, have garnered significant attention. These materials are extensively used in a range of biomedical applications. This study synthesized several injectable composite hydrogels through the mild Schiff base reaction while imposing different concentrations of quaternary ammonium chitosan and oxidized pullulan.

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There was arising osteoporosis from an imbalance in bone remodeling, with excessive differentiation of bone marrow mesenchymal stem cells (BMSCs) into adipocytes instead of osteoblasts. In this study, we found IKKε was upregulated in osteoporotic bone and knockdown promoted osteoblast differentiation. We explored amlexanox (AM), a novel IKKε inhibitor, for its effects on osteogenic differentiation and bone homeostasis.

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A novel method coupling solid-phase microextraction (SPME) to solid-phase dielectric barrier discharge (SPDBD) vapor generation was proposed and used for the sensitive detection of trace mercury (Hg) in seawater with atomic fluorescence spectrometry (AFS) in this work. The method proposed herein offers the unique advantages of integrating desorption and chemical vapor generation into one step, eliminating the use of elution reagents, and reducing the analysis time. SPME with multiwalled carbon nanotubes (MWCNTs) coated on the glass tube was used to extract Hg in seawater.

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Article Synopsis
  • The LMNA gene encodes lamin A/C proteins, essential for the nuclear lamina, which plays vital roles in cell structure, gene regulation, mechanosensing, and motility.
  • Mutations or improper expression of the LMNA gene can lead to "laminopathies," a group of diseases directly linked to its dysfunction.
  • The review highlights recent research on LMNA's role in diseases, especially tumors, examining how alterations in the gene affect cancer and the associated signaling pathways, offering new insights for future studies.
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  • Biological neurons process information in complex ways, outperforming traditional models in neuromorphic computing, especially in Boolean algebra operations.
  • A single-transistor neuron utilizing graphene's properties can execute multiple Boolean operations efficiently, unlike conventional circuits that need many transistors for certain tasks.
  • This research lays the groundwork for advanced computations at the transistor level, aiming for more scalable and efficient neural networks that mimic brain functions.
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  • The study explored the connection between the neutrophil-to-lymphocyte ratio (NLR) and mortality risks in chronic obstructive pulmonary disease (COPD) patients, aiming to clarify its role as a potential biomarker for systemic inflammation and immune activation.
  • Data from the National Health and Nutrition Examination Survey (NHANES) was used to analyze 716 COPD patients over a median follow-up of 111.5 months, determining the impact of higher NLR (≥2.56) on mortality rates.
  • Results indicated that patients with higher NLR had more than double the risk of all-cause mortality (HR = 2.07) and cardiovascular mortality (HR = 3.03) compared to those
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Article Synopsis
  • High-entropy layered double hydroxides (HE-LDHs) are promising materials, but they typically lack thermal stability, limiting their use in thermo-catalysis.
  • A new method for creating HE-LDHs is introduced, which involves carefully controlling the nucleation of metal ions to improve thermal stability and prevent phase issues at high temperatures.
  • The resulting HE-LDHs can withstand temperatures up to 300 °C, maintain essential acidic properties, and effectively remove unwanted compounds from fuel oils in catalytic reactions, showcasing their enhanced stability and potential for practical applications.
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Rheumatoid arthritis (RA) is an autoimmune-mediated disease with the highest disability rate. Sporidiobolus pararoseus polysaccharides (SPP) have been demonstrated to have anti-rheumatoid and microbiota-modulatory effects; however, the underlying mechanisms remain unclear. This study employed collagen-induced arthritis (CIA) mice to explore the metabolic and genetic pathways.

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