Focal pyroptosis-related genes and are prognostic markers for triple-negative breast cancer with brain metastases.

Background: Extensive research has shown the role of pyroptosis in the occurrence, progression, and prognosis of breast cancer. The study sought to screen important pyroptosis-related genes and their role in the prognosis of triple-negative breast cancer (TNBC) patients with brain metastasis (BM).

Methods: The Gene Expression Omnibus database was used to obtain transcriptome data from primary TNBC and from TNBC BM patients.