Publications by authors named "Qia Liu"
Article Synopsis
- PROTACs are a promising new tool for drug discovery and understanding protein functions, but developing them is currently slow and labor-intensive.
- A new strategy aims to streamline the synthesis of PROTAC libraries by using a process that allows the reaction products to be directly tested in cell-based assays, eliminating the need for painstaking purification.
- This technique demonstrated success by identifying effective PROTACs that inhibit tumor growth in triple-negative breast cancer, showcasing its potential for high-throughput synthesis and speeding up the discovery process.
Resveratrol (3,5,4'-trihydroxy-trans-stilbene), a polyphenol found in the skin of the grape and red wine, has been found to have chemopreventitive effects in some carcinogenic models. The effects of resveratrol on the initiation of Barrett's metaplasia and the carcinogenic progression to esophageal adenocarcinoma have not been evaluated. The aim of this study was to evaluate the effects of resveratrol on the transition from reflux esophagitis to Barrett's metaplasia to dysplasia to esophageal adenocarcinoma in an established rat model.
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