Cadherin 23 is a prognostic marker of pancreatic cancer and promotes cell viability in floating culture conditions.

: Pancreatic cancer has the worst prognosis of all common cancers worldwide. Cadherin plays important roles in cancer cell invasion and metastasis. This study investigated the role and mechanism of Cadherin 23 (CDH23) action in the viability of pancreatic cancer cells.

Inactivation of ERK1/2 in cancer-associated hepatic stellate cells suppresses cancer-stromal interaction by regulating extracellular matrix in fibrosis.

The ERK1/2 pathway is involved in epithelial-mesenchymal transformation and cell cycle of tumor cells in hepatocellular carcinoma (HCC). In the present study, we investigated the involvement of ERK1/2 activation on hepatic stellate cells (HSCs). We identified ERK1/2 phosphorylation in activated HSCs of HCC samples.

Photonic approach for Doppler-frequency-shift and angle-of-arrival measurement with direction unambiguity and high precision.

A novel, to the best of our knowledge, scheme based on a dual-drive Mach-Zehnder modulator (DDMZM) is proposed for Doppler-frequency-shift (DFS) and angle-of-arrival (AOA) measurement without direction ambiguity. The echo signal from one antenna is coupled with a local oscillator and then fed into the upper RF port of the DDMZM, and the echo signal from the other one is directly fed to its lower RF port. The generated two first-order optical sidebands are separated by an interleaver to form two channels and then detected by two identical low-speed photodiodes, and so both magnitude and orientation of the AOA and DFS can be deduced from the power and frequency of the beating signals.

Identification of the miR-423-3p/VLDLR Regulatory Network for Glioma Using Transcriptome Analysis.

As the most prevalent primary CNS tumor, glioma is characterized by high mortality and morbidity. This research aims to investigate glioma-associated microRNAs (miRNAs) and their target mRNAs, as well as to explore their biological functions in gliomas. The Gene Expression Omnibus (GEO) database was applied to acquire the GSE112264 miRNA microarray dataset and the GSE15824 mRNA dataset.

Isoschaftoside Reverses Nonalcoholic Fatty Liver Disease via Activating Autophagy and .

Nonalcoholic fatty liver disease (NAFLD) is the most common metabolic liver disease globally, and the incidence of NAFLD has been increasing rapidly year by year. Currently, there is no effective pharmacotherapy for NAFLD. Therefore, studies are urgently needed to explore therapeutic drugs for NAFLD.

Inhibition of NEK7 Suppressed Hepatocellular Carcinoma Progression by Mediating Cancer Cell Pyroptosis.

NIMA-related kinase 7 (NEK7) is a serine/threonine kinase involved in cell cycle progression mitotic spindle formation and cytokinesis. It has been related to multiple cancers, including breast cancer, hepatocellular cancer, lung cancer, and colorectal cancer. Moreover, NEK7 regulated the NLRP3 inflammasome to activate Caspase-1, resulting in cell pyroptosis.

NEK7 Promotes Pancreatic Cancer Progression And Its Expression Is Correlated With Poor Prognosis.

The prognosis for pancreatic ductal adenocarcinoma (PDAC) patients is still dismal. Elucidation of associated genomic alteration may provide effective therapeutic strategies for PDAC treatment. NIMA-related protein kinase 7 is widely expressed in various tumors, including breast cancer, colorectal cancer and lung cancer, and promotes the proliferation of liver cancer cells and .

Synergy of Pore Size and Specific Surface Area on the CO₂ Sorption Performance of Nano CaO-Based Sorbents.

This study focuses on the synergy effect of pore size and specific surface area (SSA) on the carbon dioxide sorption performance. Nano CaO-based CO₂ sorbents with various pore size (15-55 nm) under similar SSA, and different SSA (14.50-48.