Making waves: Power-to-X for the Water Resource Recovery Facilities of the future.

The wastewater industry and the energy system are undergoing significant transformations to address climate change and environmental pollution. Green hydrogen, which will be mainly obtained from renewable electricity water electrolysis (Power-to-Hydrogen, PtH), has been considered as an essential energy carrier to neutralize the fluctuations of renewable energy sources. PtH, or Power-to-X (PtX), has been allocated to multiple sectors, including industry, transport and power generation.

Schlafen-5 inhibits LINE-1 retrotransposition.

Long interspersed element 1 (LINE-1) is the only currently known active autonomous transposon in humans, and its retrotransposition may cause deleterious effects on the structure and function of host cell genomes and result in sporadic genetic diseases. Host cells therefore developed defense strategies to restrict LINE-1 mobilization. In this study, we demonstrated that IFN-inducible Schlafen5 (SLFN5) inhibits LINE-1 retrotransposition.

Prognostic and Clinical Significance of Human Leukocyte Antigen Class I Expression in Breast Cancer: A Meta-Analysis.

Background: The value of human leukocyte antigen (HLA; also known as major histocompatibility complex) class I expression for the prediction of breast cancer survival outcomes remains unclear. We conducted a meta-analysis to explore the prognostic significance of this expression.

Materials And Methods: We searched electronic databases to identify reports on associations of HLA class I protein or mRNA expression with survival outcomes and clinicopathological factors in the breast cancer context.

Formation of a PVP-protected C/UO/Pt catalyst in a direct ethanol fuel cell.

In order to solve the problem that UO in direct ethanol fuel cell anode catalysts is easily lost in acidic solution, resulting in the degradation of catalytic performance, this paper prepared a C/UO/PVP/Pt catalyst in three steps by adding polyvinylpyrrolidone (PVP). The test results by XRD, XPS, TEM and ICP-MS showed that PVP had a good encapsulation effect on UO, and the actual loading rates of Pt and UO were similar to the theoretical values. When 10% PVP was added, the dispersion of Pt nanoparticles was significantly improved, which reduced the particle size of Pt nanoparticles and provided more ethanol electrocatalytic oxidation reaction sites.

Pathological complete response and prognosis after neoadjuvant chemotherapy in patients with HER2-low breast cancer.

Background: The development of novel human epidermal growth factor receptor 2 (HER2) antibody drug conjugates brings encouraging opportunities for the treatment of HER2-low breast cancer. In this study, we investigated the clinical factors and prognosis of HER2-low breast cancer after neoadjuvant chemotherapy (NAC).

Methods: Data from patients diagnosed with HER2-zero or HER2-low breast cancer at a single center between January 2017 and December 2021 who underwent NAC followed by surgery were retrospectively reviewed.

Empathy and depression among a Chinese sample: The moderating role of rumination and attentional shift.

Background: Although previous studies have explored the moderating role of emotional regulation strategies in the relationship between empathy and depression, no studies have studied the moderating role of attentional control in the relationship between empathy and depression. To address this research gap, the present study investigated the moderating roles of rumination and attentional control in the relationship between empathy and depression.

Methods: 423 participants filled out questionnaires anonymously, including Interpersonal Reactivity Index, Attention Control Scale, Self-rating Depression Scale, and Rumination Response Scale.

Are Perfectionists Always Dissatisfied with Life? An Empirical Study from the Perspective of Self-Determination Theory and Perceived Control.

Compared to non-perfectionists, perfectionists may not be satisfied with the growing needs in their lives to the same extent. To test whether perfectionists are dissatisfied with their lives, we investigated whether trait perfectionism attenuates the relationship between basic psychological needs, perceived control, and life satisfaction. A total of 574 college students self-reported basic psychological needs, perceived control, life satisfaction, and perfectionistic strivings and concerns, with a mean age of 19.

NCAPH promotes proliferation as well as motility of breast cancer cells by activating the PI3K/AKT pathway.

Objective: This study aimed to assess the expression of NCAPH in human breast cancer, and to investigate its effects on breast cancer cells.

Methods: Bioinformation analysis was performed to analyze the expression of NCAPH in human breast cancer tissues and normal tissues in TCGA database. qPCR and Immunoblot assays were performed to clarify the expression of NCAPH in breast cancer tissues and cell lines, respectively.

A PRC2-independent function for EZH2 in regulating rRNA 2'-O methylation and IRES-dependent translation.

Dysregulated translation is a common feature of cancer. Uncovering its governing factors and underlying mechanism are important for cancer therapy. Here, we report that enhancer of zeste homologue 2 (EZH2), previously known as a transcription repressor and lysine methyltransferase, can directly interact with fibrillarin (FBL) to exert its role in translational regulation.

Excellent electrochemical stability of CoOarray with carbon hybridization derived from metal-organic framework.

Hybrid supercapacitors have attracted considerable attention for the use in the energy storage systems due to the simultaneous possession of high power and energy. Herein, CoOarray with amorphous carbon on Ni foam has been derived from the Co-MOF. The electrochemical dynamics and energy storage mechanism of the prepared electrode have been investigated, which reveals the enhancement of the capacitive behavior with the scan rate.

Demand response through reject water scheduling in water resource recovery facilities: A demonstration with BSM2.

The objective of this paper is to determine the importance of integrating peak demand mitigation and future energy pricing structures for process modelling of conventional water resource recovery facilities (WRRFs) when evaluating energy cost and control strategies. The well-established benchmark simulation model (BSM2) is used to monitor energy usage, and a detailed holistic study of different flow streams is performed in order to establish potential opportunities for flexible control of WRRF energy demand. Secondly, a detailed framework is introduced to optimize scheduling control strategies for the reject water stream while considering peak electricity demand avoidance as well as completing a comprehensive energy cost model based on current and anticipated future energy tariff structures.

Antihistamine Drug Ebastine Inhibits Cancer Growth by Targeting Polycomb Group Protein EZH2.

Enhancer of zester homolog 2 (EZH2), a histone lysine methyltransferase and the catalytic component of polycomb repressive complex 2, has been extensively investigated as a chromatin regulator and a transcriptional suppressor by methylating H3 at lysine 27 (H3K27). EZH2 is upregulated or mutated in most cancers, and its expression levels are negatively associated with clinical outcomes. However, the current developed small-molecule inhibitors targeting EZH2 enzymatic activities could not inhibit the growth and progression of solid tumors.

Intersection management for autonomous vehicles with vehicle-to-infrastructure communication.

This paper proposes an intersection management strategy for autonomous vehicles under the vehicle-to-infrastructure circumstance. All vehicles are supposed to be fully autonomous and can communicate with the intersection management unit to check the traffic situation. Priority of passing the intersection is decided by a static conflict matrix which represents the potential conflict between lanes of different directions and a dynamic information list which could capture the real-time occupation of each lane in the intersection.

Protective Effects of Lixisenatide against Lipopolysaccharide-Induced Inflammation Response in MAC-T Bovine Mammary Epithelial Cells: A Therapeutic Implication in Mastitis.

Mastitis is acute inflammation caused by microbial infections in the mammary glands. This disease is extremely harmful to lactating mothers. The preferred clinical strategy is antibiotic treatment, but this method results in resistance and side effects.

Benchmarking leachate co-treatment strategies in municipal wastewater treatment plants under dynamic conditions and energy prices.

Combined leachate treatment at municipal wastewater treatment plants (WWTPs) is applicable to a certain extent depending on the leachate composition, treatment plant configuration and its capacity. Co-treatment of leachate at WWTPs has several advantages, but due to increasingly stringent discharge standards applied in WWTPs, it has become more problematic. This study was undertaken to investigate the impact of leachate feeding strategies on effluent quality and the aeration energy costs of WWTPs.

Highly Selective Adsorption on SiSe Monolayer and Effect of Strain Engineering: A DFT Study.

The adsorption types of ten kinds of gas molecules (O, NH, SO, CH, NO, HS, H, CO, CO, and NO) on the surface of SiSe monolayer are analyzed by the density-functional theory (DFT) calculation based on adsorption energy, charge density difference (CDD), electron localization function (ELF), and band structure. It shows high selective adsorption on SiSe monolayer that some gas molecules like SO, NO, and NO are chemically adsorbed, while the NH molecule is physically adsorbed, the rest of the molecules are weakly adsorbed. Moreover, stress is applied to the SiSe monolayer to improve the adsorption strength of NH.

BMI1 is directly regulated by androgen receptor to promote castration-resistance in prostate cancer.

B lymphoma Mo-MLV insertion region 1 (BMI1) has been reported to be an oncoprotein. BMI1 represses tumor suppressors to promote cell proliferation, epithelial-mesenchymal transition (EMT), and cancer progression. Although it is known that the expression of BMI1 is increased in many cancer types, the mechanism of BMI1 upregulation is not yet clear.

Fully Alloying AuAg Nanorods in a Photothermal Nano-Oven: Superior Plasmonic Property and Enhanced Chemical Stability.

Fully alloyed metallic nanomaterials have attracted much attention because of the superior chemical and physical properties to their single components. However, it has been difficult to make fully alloyed anisotropic nanostructures due to the required high energy input. Here we present the preparation of fully alloyed AuAg nanorods by using a photothermal nano-oven, in which Au@Ag nanorods can convert absorbed light to thermal energy while the silica shell can act as both the thermal insulator and protective layer to facilitate the alloying process.

Prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio for breast cancer patients: An updated meta-analysis of 17079 individuals.

Aims: This study aimed to evaluate the prognostic effect of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) for patients with breast cancer (BC).

Methods: A literature search was performed by searching medical databases. Basic characteristics and prognostic data were extracted from included studies.

Polycomb group proteins EZH2 and EED directly regulate androgen receptor in advanced prostate cancer.

Polycomb group proteins are important epigenetic regulators for cell proliferation and differentiation, organ development, as well as initiation and progression of lethal diseases, including cancer. Upregulated Polycomb group proteins, including Enhancer of zeste homolog 2 (EZH2), promote proliferation, migration, invasion and metastasis of cancer cells, as well as self-renewal of cancer stem cells. In our study, we report that EZH2 and embryonic ectoderm development (EED) indicate respective direct interaction with androgen receptor (AR).

B lymphoma Moloney murine leukemia virus insertion region 1: An oncogenic mediator in prostate cancer.

B lymphoma Moloney murine leukemia virus insertion region 1 (BMI1), a core member of polycomb repressive complex 1 (PRC1), has been intensely investigated in the field of cancer epigenetics for decades. Widely known as a critical regulator in cellular physiology, BMI1 is essential in self-renewal and differentiation in different lineages of stem cells. BMI1 also plays a significant role in cancer etiology for its involvement in pathological progress such as epithelial-mesenchymal transition (EMT) and cancer stem cell maintenance, propagation, and differentiation.

Prognostic and clinicopathological value of CXCL12/SDF1 expression in breast cancer: A meta-analysis.

Background: Several studies have demonstrated that stromal cell derived factor-1 (SDF1, also known as CXCL12) expression is a biomarker for breast cancer treatment; however, its significance of prognosis is inconsistent. This study uses a meta-analysis to explore the prognostic value of CXCL12/SDF1 expression in breast cancer.

Materials And Methods: PubMed, Embase, Cochrane Library, and Web of Science databases were searched from inception to November 25, 2017.