Preparation and evaluation of paclitaxel-loaded reactive oxygen species and glutathione redox-responsive poly(lactic-co-glycolic acid) nanoparticles for controlled release in tumor cells.

To formulate and assess the anticancer effect of the poly(lactic-co-glycolic acid) (PLGA) copolymer with the thioether groups (diethyl sulfide [Des]) and disulfide bond (cystamine containing disulfide [Cys]), which encapsulated the anticancer drug paclitaxel (PTX) and triggered PTX release in cancer cell HO-rich or glutathione-rich surroundings. PLGA--P (Des@Cys) and PLGA--P nanoparticles loaded with PTX were prepared and characterized . The delivery ability of the PLGA--P nanoparticles and PLGA--P-PTX nanoparticles was assessed on a CT26 (mouse colon cancer cell line) and mouse lung cancer LLC model.

Antioxidative Activity Evaluation of High Purity and Micronized Tartary Buckwheat Flavonoids Prepared by Antisolvent Recrystallization.

Tartary buckwheat, a healthy food, is associated with a reduced risk of certain human chronic diseases. However, the bioactive component flavonoids in Tartary buckwheat have poor solubility and low absorption in vivo. To improve these points, 60.

Study on the preparation and activity of intelligent response poly(lactic-co-glycolic acid)-ss-polyethylene glycol copolymer micelles.

Amphiphilic polymer micellar carriers are the most commonly used nanocarriers for oral delivery of hydrophobic drugs because their hydrophilic shell can avoid the recognition of the reticuloendothelial system (RES), has excellent drug-carrying capacity, and protect the drug from inactivation in the gastrointestinal fluid. The polymer micelle shell can enter cancer cells by endocytosis, and autophagy in cells, degradation by lysosomal pathway, so as to release drugs, prolong the circulation time of drugs in vivo, and then achieve the effect of drug sustained release. In this study, the glutathione-responsive PLGA-ss-PEG loaded paclitaxel (PTX) micelles (PLGA-ss-PEG-PTX) were developed for anticancer therapy.

Artemisinin hydroxypropyl-β-cyclodextrin inclusion complex loaded with porous starch for enhanced bioavailability.

The current work aimed to enhance the oral bioavailability of water-insoluble drug Artemisinin (ART) by the inclusion of ART with hydroxypropyl-β-cyclodextrin (HP-β-CD) and then loaded with porous starch (PS). The preparation conditions of ART HP-β-CD inclusion complex loaded with PS (AHPS) were optimized according to drug loading (DL) and entrapment efficiency (EE). The properties of AHPS were characterized by optical and thermodynamic methods.

Activating Surface Lattice Oxygen of a Cu/ZnCuO Catalyst through Interface Interactions for CO Oxidation.

Surface lattice oxygen in metal oxides is a common participant in many chemical reactions. Given this, the structural design of catalysts to activate lattice oxygen and moreover investigations into the effect of lattice oxygen on reaction pathways are hot topics. With this in mind, herein we prepare CuO-ZnCuO (ZCO) nanofibers akin to the Trojan horse legend and via an in situ reduction obtain activated Cu/ZnCuO (Cu/ZCO) nanofibers.

Crystal Structure, Solubility, and Pharmacokinetic Study on a Hesperetin Cocrystal with Piperine as Coformer.

Hesperetin (HES) is a key biological active ingredient in citrus peels, and is one of the natural flavonoids that attract the attention of researchers due to its numerous therapeutic bioactivities that have been identified in vitro. As a bioenhancer, piperine (PIP) can effectively improve the absorption of insoluble drugs in vivo. In the present study, a cocrystal of HES and PIP was successfully obtained through solution crystallization.

Synergistic Effects of a CeO/SmMnO-H Diesel Oxidation Catalyst Induced by Acid-Selective Dissolution Drive the Catalytic Oxidation Reaction.

A diesel oxidation catalyst (DOC) is installed upstream of an exhaust after-treatment line to remove CO and hydrocarbons and generate NO. The catalyst should possess both good oxidation ability and thermal stability because it sits after the engine. We present a novel high-performance DOC with high steam resistance and thermal stability.

Improved water dispersion and bioavailability of coenzyme Q10 by bacterial cellulose nanofibers.

The purpose of this study was to investigate the potential of bacterial cellulose nanofiber suspension (BCNs) as stabilizer in anti-solvent precipitation and its effect on improving bioavailability of coenzyme Q10. Bacterial cellulose (BC) was hydrolyzed by sulfuric acid followed by the oxidation with hydrogen peroxide to prepare BCNs. The suspension of BCNs-loaded CoQ10 (CoQ10-BCNs) were prepared by antisolvent precipitation.

Phloretin loaded porous starch (Ph-PS): Preparation, characterization, in vitro release and protective effect against oxidative stress in vivo zebrafish model.

Phloretin loaded porous starch (Ph-PS) were prepared for its application in food. The effects of Ph-PS in vitro release and its ability against AAPH-induced oxidative stress in vivo zebrafish model were investigated. Ph-PS was prepared by absorption method, the physical and chemical characterization showed that PS decreased the crystallinity of Ph obviously.

Tunable metal-support interaction of Pt/CeO catalyst via surfactant-assisted strategy: Insight into the total oxidation of CO and toluene.

Catalytic oxidation is promising in removing atmospheric pollutants to address serious environmental concerns. Supported Pt-based catalysts (e.g.

Improving the antioxidant activity of natural antioxidant honokiol by introducing the amino group.

Exploring and synthesizing the compounds with stronger antioxidant activity have always been the goal of researchers. Herein, the substitution effects of the amino (NH-) group with the excellent electron-donating ability in different positions on the antioxidant activity of Honokiol (Hon) were systematically explored by using the quantum chemistry calculation based on the density functional theory method. The three possible antioxidant mechanisms of Hon and its four NH-substituted derivatives (Hon1-Hon4), containing the hydrogen atom transfer (HAT), single electron transfer followed by proton transfer (SET-PT), and sequential proton loss electron transfer (SPLET), were explored in depth considering the gas and solvent phases.

Fabrication of Nanohybrid Spinel@CuO Catalysts for Propane Oxidation: Modified Spinel and Enhanced Activity by Temperature-Dependent Acid Sites.

Modulating the catalyst electronic structure is a promising direction to enhance the catalytic oxidation performance. Herein, we report an innovative synthesis of the nanohybrid spinel@CuO catalyst with a broad biphasic interface for propane oxidation. The reaction rate of spinel@CuO catalyst was significantly increased compared to the physically mixed spinel+CuO catalyst.

Synthesis of α-MnO-like rod catalyst using YMnO A-site sacrificial strategy for efficient benzene oxidation.

The elimination of benzene, a typical volatile organic pollutant, is one of the most challenging topics for environmental scientists. Catalytic oxidation technology is considered the most efficient approach for its elimination. Herein, we report the successful preparation of a novel α-MnO-like rod catalyst via an acid etching route and propose YMnO mullite as a novel precursor.

Enhanced Water Solubility and Oral Bioavailability of Paclitaxel Crystal Powders through an Innovative Antisolvent Precipitation Process: Antisolvent Crystallization Using Ionic Liquids as Solvent.

Paclitaxel (PTX) is a poor water-soluble antineoplastic drug with significant antitumor activity. However, its low bioavailability is a major obstacle for its biomedical applications. Thus, this experiment is designed to prepare PTX crystal powders through an antisolvent precipitation process using 1-hexyl-3-methylimidazolium bromide (HMImBr) as solvent and water as an antisolvent.

Deactivation Mechanism of Multipoisons in Cement Furnace Flue Gas on Selective Catalytic Reduction Catalysts.

Increasing numbers of cement furnaces have applied selective catalytic reduction (SCR) units for advanced treatment of NO in the flue gas. However, the SCR catalysts may face various poisons, such as acidic, alkaline, and heavy metal species, in the fly ash. In this work, we studied the deactivation mechanisms of multipoisons (Ca, Pb, and S) on the CeO-WO/TiO catalyst, using the in situ diffuse reflectance infrared Fourier transform spectroscopy method.

Melatonin loaded with bacterial cellulose nanofiber by Pickering-emulsion solvent evaporation for enhanced dissolution and bioavailability.

The objective of the present work aimed to explore the potential of bacterial cellulose (BC) for oral delivery of melatonin (MLT), a natural hormone that faces problems of low solubility and oral bioavailability. BC was hydrolyzed by sulfuric acid followed by the oxidation to prepare bacterial cellulose nanofiber suspension (BCNs). Melatonin-loaded bacterial cellulose nanofiber suspension (MLT-BCNs) was prepared by emulsion solvent evaporation method.

Performance of Modified La SrMnO Perovskite Catalysts for NH Oxidation: TPD, DFT, and Kinetic Studies.

The modified perovskites (La SrMnO) were prepared using the selective dissolution method for the selective catalytic oxidation (SCO) of NH. We found that more Mn cations and active surface oxygen species formed on the catalyst's surface with increasing the dissolution time (dis). The 1h-dis catalyst exhibited excellent NH conversion, and it performed well in the presence of SO and HO.