Sirtuin1 mitigates hypoxia-induced cardiomyocyte apoptosis in myocardial infarction via PHD3/HIF-1α.

Background: Acute myocardial infarction (AMI) is a leading cause of mortality, characterized by myocardial ischemia that induces cardiomyocyte apoptosis and subsequent cardiac dysfunction. Sirtuin 1 (Sirt1) has emerged as a key regulator of cell survival and apoptosis, particularly under hypoxic conditions.

Methods: An AMI animal model was established via ligation of the left anterior descending (LAD) coronary artery.

Refining habitat selection for sulfate-reducing bacteria: Evaluating suitability and adaptability for sulfate-metal wastewater treatment during anaerobic-to-aerobic transitions.

Inoculating sulfate-reducing bacteria (SRB) habitats offers an eco-friendly method for treating sulfate-metal laden wastewater, characterized by high sulfate levels, low pH, and elevated heavy metals. This study optimizes source habitat selection of SRB by evaluating groundwater, sewage sludge, and lake sediment, focusing on their suitability and adaptability to aerobic-anaerobic transitions in industrial settings. Sewage sludge, with its slightly acidic pH, reducing environment, and high nutrient levels (Total organic carbon: 207.

Groenlandicine enhances cisplatin sensitivity in cisplatin-resistant osteosarcoma cells through the BAX/Bcl-2/Caspase-9/Caspase-3 pathway.

Groenlandicine is a protoberberine alkaloid isolated from , a widely used traditional Chinese medicine known for its various biological activities. This study aims to validate groenlandicine's effect on both cisplatin-sensitive and cisplatin-resistant osteosarcoma (OS) cells, along with exploring its potential molecular mechanism. The ligand-based virtual screening (LBVS) method and molecular docking were employed to screen drugs.

Mechanisms of myocardial toxicity of antitumor drugs and potential therapeutic strategies: A review of the literature.

With the successive development of chemotherapy drugs, good results have been achieved in clinical application. However, myocardial toxicity is the biggest challenge. Anthracyclines, immune checkpoint inhibitors, and platinum drugs are widely used.

Regulatory T cells as a therapeutic target in acute myocardial infarction.

Acute myocardial infarction (AMI), mainly triggered by vascular occlusion or thrombosis, is the most prevalent cause of morbidity and mortality among all cardiovascular diseases. The devastating consequences of AMI are further aggravated by the intricate cellular processes involved in inflammation. In the past two decades, many studies have reported that regulatory T cells (Tregs), as the main immunoregulatory cells, play a crucial role in AMI progression.

Harnessing sulfate-reducing bacteria with plants growing to revitalize metal-tainted coal mine soils in Midwest China: metal sequestration performance, ecological networking interaction, and functional enzymatic prediction.

Heavy metal contamination from coal mining calls for advanced bioremediation, i.e., using sulfate-reducing bacteria (SRB) technology.

Construction of a multifunctional dual-network chitosan composite aerogel with enhanced tunability.

Typically, the tailorable versatility of biomass aerogels is attributed to the tunable internal molecular structure, providing broad application prospects. Herein, a simple and novel preparation strategy for developing multifunctional dual-network chitosan/itaconic acid (CSI) aerogel with tunability by using freeze-drying and vacuum heat treatment techniques. By regulating the temperature and duration of amidation reaction, electrostatic interactions between chitosan (CS) and itaconic acid (IA) was abstemiously converted into amide bond in frozen aerogel, with IA acting as an efficient in-situ cross-linking agent, which yielded CSI aerogels with different electrostatic/covalent cross-linking ratios.

Influence of Coal Gangue Powder on the Macroscopic Mechanical Properties and Microstructure of Recycled Aggregate Concrete.

The construction and coal industries generate substantial industrial waste, including coal gangue and construction and demolition (C&D) waste, leading to environmental pollution and high disposal costs. Integrating recycled aggregates (RAs) and coal gangue powder (CGP) into concrete is an effective approach for waste management. However, CGP can affect the performance of traditional recycled concrete.

Recent Advances in Metal-Organic Framework (MOF)-Based Photocatalysts: Design Strategies and Applications in Heavy Metal Control.

The heavy metal contamination of water systems has become a major environmental concern worldwide. Photocatalysis using metal-organic frameworks (MOFs) has emerged as a promising approach for heavy metal remediation, owing to the ability of MOFs to fully degrade contaminants through redox reactions that are driven by photogenerated charge carriers. This review provides a comprehensive analysis of recent developments in MOF-based photocatalysts for removing and decontaminating heavy metals from water.

The metabolomic plasma profile of patients with Duchenne muscular dystrophy: providing new evidence for its pathogenesis.

Background: Duchenne muscular dystrophy (DMD) is a fatal genetic muscle-wasting disease that affects 1 in 5000 male births with no current cure. Despite great progress has been made in the research of DMD, its underlying pathological mechanism based on the metabolomics is still worthy of further study. Therefore, it is necessary to gain a deeper understanding of the mechanisms or pathogenesis underlying DMD, which may reveal potential therapeutic targets and/or biomarkers.

Mn/Ce@HKUST-1 for Efficient Removal of Gaseous Thallium: Insights from Kinetic and Experimental Studies.

Gaseous thallium (Tl) pollution events, primarily caused by non-ferrous mineral refineries and fossil fuel combustion, have increased over the past few decades. To prevent gaseous Tl distribution from flue gas, MnO/CeO@HKUST-1 (MCH) was synthesized and found to achieve a gaseous Tl(I) removal level of up to 90% at 423 K, a weight hourly space velocity (WHSV) of 2000 h/mL with an Mn dose of 10%, maintained over 10 h. The best Mn/Ce ratio was found to be 9:1.

Glucagon-Like Peptide-1 Inhibits the Progression of Abdominal Aortic Aneurysm in Mice: The Earlier, the Better.

Objectives: Glucagon-like peptide-1 (GLP-1) has a cardiovascular protective effect by preventing abdominal aortic aneurysm (AAA) formation. However, it is unclear at what point the agent should be administered to achieve the optimal effect. In this study, we aimed to determine whether administering the GLP-1 receptor agonist liraglutide during the earlier stages would more efficiently inhibit AAA progression in mice.

Characterization of early myocardial inflammation in ischemia-reperfusion injury.

Background: Myocardial injury may be caused by myocardial ischemia-reperfusion (IR), and salvaging such an injury is still a great challenge in clinical practice. This study comprehensively characterized the physiopathologic changes of myocardial injury after IR to explore the underlying mechanism in the early reperfusion phase with particular emphasis on early myocardial inflammation.

Methods And Results: The experimental IR model was obtained by the left anterior descending artery's transient ligation of C57BL/6 mice.

Intravascular ultrasound provides additional insights in the hypertensive patients with focal renal artery fibromuscular dysplasia.

To date, few study has defined the exact role or utility of intravascular ultrasound (IVUS) in the diagnosis and treatment of renal artery fibromuscular dysplasia (FMD). We investigated whether using an IVUS would provide additional insights in the hypertensive patients with focal renal artery FMD. A prospective, observational study, including all patients with focal renal artery FMD admitted to the Ruijin hospital during 6 consecutive years (2015-2021).

A Multifunctional Integrated Metal-Free MRI Agent for Early Diagnosis of Oxidative Stress in a Mouse Model of Diabetic Cardiomyopathy.

Reactive oxygen species (ROS) are closely associated with the progression of diabetic cardiomyopathy (DCM) and can be regarded as one of its early biomarkers. Magnetic resonance imaging (MRI) is emerging as a powerful tool for the detection of cardiac abnormalities, but the sensitive and direct ROS-response MRI probe remains to be developed. This restricts the early diagnosis of DCM and prevents timely clinical interventions, resulting in serious and irreversible pathophysiological abnormalities.

C1q/TNF-related protein-2 improved angiogenesis to protect myocardial function during ischaemia‒reperfusion.

Background: Collateral growth plays an important role in the recovery of acute myocardial infarction. C1q/TNF-related protein-2 (CTRP2), a CTRP family member, showed some protective effects on cell survival. In this study, the relationship between CTRP2 and collateral growth was examined.

CrX (X = Se, Te) monolayers as a new platform to realize robust spin filters, spin diodes and spin valves.

Two-dimensional ferromagnetic (FM) half-metals are promising candidates for advanced spintronic devices with small size and high capacity. Motivated by a recent report on controlling the synthesis of FM CrTe nanosheets, herein, to explore their potential application in spintronics, we designed spintronic devices based on CrX (X = Se, Te) monolayers and investigated their spin transport properties. We found that the CrTe monolayer based device shows spin filtering and a dual-spin diode effect when applying a bias voltage, while the CrSe monolayer is an excellent platform to realize a spin valve.

In vivo Detection of Macromolecule Free Radicals in Mouse Sepsis-Associated Encephalopathy Using a New MRI and Immunospin Trapping Strategy.

Introduction: Free radicals in oxidative stress are known to play a pathogenic role in sepsis. A major clinical challenge associated with sepsis is sepsis-associated encephalopathy (SAE). The rapid increase of free radicals in the brain promotes SAE progression.

Targeted trapping of endogenous endothelial progenitor cells for myocardial ischemic injury repair through neutrophil-mediated SPIO nanoparticle-conjugated CD34 antibody delivery and imaging.

Endothelia progenitor cell (EPC)-based revascularization therapies have shown promise for the treatment of myocardial ischemic injury. However, applications and efficacy are limited by the relatively inefficient recruitment of endogenous EPCs to the ischemic area, while implantation of exogenous EPCs carries the risk of tumorigenicity. In this study, we developed a therapeutic protocol that relies on the capacity of neutrophils (NEs) to target lesions and release preloaded EPC-binding molecules for high efficiency capture.

Ventilating aged-care center based on solar chimney: Design and theoretical analysis.

Natural ventilation is considered the first suggestion for COVID-19 prevention in buildings by the World Health Organization (WHO). Solar chimney's viability in aged care centers or similar facilities was analyzed numerically and theoretically. A new solar chimney design was proposed to reduce the cross-infection risk of COVID-19 based on an airflow path through window, ceiling vent, attic, and then chimney cavity.

Retrospective Study of 23 Patients with Traumatic Posterolateral Tibial Plateau Fracture Treated in a Single Center Between 2017 and 2019 with Lateral Arthrotomy, Reduction, and Plate Fixation Using the Frosch Approach.

BACKGROUND The Frosch approach is a posterolateral surgical procedure performed with or without osteotomy of the fibula for the treatment of posterolateral tibial plateau fractures (PLFs). This retrospective study from a single center aimed to evaluate 23 patients with PLFs who underwent surgical reduction with the Frosch approach between January 2017 and October 2019. MATERIAL AND METHODS Twenty-three patients, 4 with Schatzker type V and 19 with Schatzker type II fractures were enrolled.

Preparation of CSHW with Flue Gas Desulfurization Gypsum.

Calcium sulfate hemihydrate whiskers (CSHW), a multi-functional and high value-added building material, were prepared with flue gas desulfurization (FGD) gypsum by hydrothermal method, which could be a reasonable disposal of FGD gypsum. In order to obtain CSHW of a high aspect ratio, a series of manufacturing parameters such as reaction temperature, stirring speed, material-water ratio, and reaction time were investigated. The effect of stabilizing treatment and glycerol concentration on CSHW morphology were also studied by environmental scanning electron microscopy (ESEM) and statistical analysis.

Decreased Glucagon-Like Peptide-1 Is Associated With Calcific Aortic Valve Disease: GLP-1 Suppresses the Calcification of Aortic Valve Interstitial Cells.

This study explores the concentration and role of glucagon-like peptide-1 (GLP-1) in calcific aortic valve disease (CAVD). Calcific aortic valve disease is a chronic disease presenting with aortic valve degeneration and mineralization. We hypothesized that the level of GLP-1 is associated with CAVD and that it participates in the calcification of aortic valve interstitial cells (AVICs).

Diurnal blood pressure pattern and cardiac damage in hypertensive patients with primary aldosteronism.

Purpose: The aim of our study was to evaluate the relationship between the 24-h blood pressure (BP) profile, plasma NT-proBNP levels and left ventricular hypertrophy (LVH) in subjects with primary aldosteronism (PA) compared to patients with essential hypertension (EH).

Methods: A total of 385 consecutive patients with PA [187 with aldosterone producing adenoma (APA) and 198 with idiopathic hyperaldosteronism (IHA)] and 385 patients with EH were matched based on age, sex, body mass index (BMI), BP values and duration of hypertension. Twenty-four-hour ambulatory BP monitoring (ABPM), plasma levels of NT-proBNP, left ventricular mass index (LVMI), and other clinical medical data were assessed in all patients.