Publications by authors named "Qi-yin Zhou"
Article Synopsis
- Cullin-RING ubiquitin ligase 4 (CRL4) is linked to ovarian cancer development, with the protein DCAF13 playing a crucial role in this process.
- High levels of DCAF13 are associated with poor survival rates in ovarian cancer patients, and knocking it out significantly reduces cancer cell growth and movement.
- The study reveals that DCAF13 promotes tumor growth by targeting FRAS1 for degradation, which in turn activates the FAK signaling pathway, suggesting potential therapeutic targets for ovarian cancer treatment.
Tubal pregnancy is a common cause of maternal mortality in early pregnancy. Transumbilical laparoendoscopic single-site surgery (TU-LESS) has gained popularity due to its safety and aesthetic advantages. However, the lack of affordable disposable entry platforms hinders its widespread adoption.
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- Cell senescence can inhibit oncogene activation, presenting a possible strategy to disrupt tumor cell functions, particularly in ovarian cancer where S1PR1 has been found to play a significant role.* -
- In ovarian cancer, deleting S1PR1 slows cell growth and movement, promotes senescence, and enhances sensitivity to chemotherapy, particularly cisplatin.* -
- The study identifies the S1PR1-PDK1-LATS1/2-YAP signaling pathway as a key regulator of ovarian cancer cell senescence, suggesting that targeting this pathway could improve standard treatment outcomes.*
Platinum-based chemotherapy is one of the predominant strategies for treating ovarian cancer (OC), however, platinum resistance greatly influences the therapeutic effect. Circular RNAs (circRNAs) have been found to participate in the pathogenesis of platinum resistance. Our aim was to explore the involvement of circ_0078607 in OC cell cisplatin (DDP) resistance and its potential mechanisms.
View Article and Find Full Text PDFEpigenetic alterations have been functionally linked to ovarian cancer development and occurrence. The CXXC zinc finger protein 1 (CFP1) is an epigenetic regulator involved in DNA methylation and histone modification in mammalian cells. However, its role in ovarian cancer cells is unknown.
View Article and Find Full Text PDFFour xanthones were isolated from Gentianopsis paludosa Ma and were identified by modern spectroscopic methods. Cytotoxicity of the four xanthones was tested on HepG2 cells and HL-60 cells by sulphorhodamine B (SRB) assay. Clonogenic survival assay, trypan blue exclusion method, AO/EB staining and DNA fragmentation assay were conducted to investigate the effect on growth inhibition and apoptosis in the two cell lines in vitro.
View Article and Find Full Text PDF1-hydroxy-3,7,8-trimethoxyxanthone (xanthone 1) was isolated from Gentianopsis paludosa Ma and identified by MS and NMR in our laboratory. In this study, the results showed that xanthone 1 is a potent inducer of anti-proliferation and apoptosis in HL-60 cells. When the cells treated with lower concentrations of xanthone 1 (12.
View Article and Find Full Text PDFWeisiensin B, a new ent-kaurane diterpenoid, was isolated from traditional Chinese herb Rabdosia weisiensis C.Y. Wu.
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