[The impact of ischemic postconditioning on the tumor necrosis factor-α/IL-6/signal transducers and activators of transcription-3 signal pathway of liver regeneration].

Objective: To investigate the impact of the ischemic postconditioning on the tumor necrosis factor (TNF)-α/IL-6/signal transducers and activators of transcription (STAT)-3 signal pathway of liver regeneration.

Methods: Ninety healthy clean grade male Sprague-Dawley rats weighting 230 to 280 g were selected and assigned into three groups randomly: group I subtotal hepatectomy (SH), group II ischemia reperfusion (IR), group III ischemic postconditioning (IPO). The left and middle liver was resected, and the remnant liver was treated as followed: the blood flow was not blocked in SH group, but blocked 30 minutes in IR group, then reperfused; IPO groups received three cycles of 30 s-30 s intermittent interruptions of blood flow at onset of reperfusion.

[Effects of ischemic postconditioning on liver regeneration and energy metabolism in rats].

Objective: To explore the effects of ischemic postconditioning on the remnant liver regeneration under ischemic reperfusion after subtotal hepatectomy.

Methods: A total of 90 male SD rats weighting 230-280 g were randomly divided into 3 groups of simple subtotal hepatectomy (SH), ischemia reperfusion (IR) and ischemic postconditioning (IPO). The left and middle liver lobes were resected.