Publications by authors named "Qi-kai Sun"
Cholangiocarcinoma (CCA) is a highly lethal malignant tumor originating from the bile duct, and its underlying mechanisms are not fully understood. In order to identify key genes in CCA, we downloaded gene expression data from public GSE76297, GSE26566 and TCGA-CHOL datasets. CARD9 was selected as a CCA-related gene from the datasets.
View Article and Find Full Text PDFTumor-associated mesenchymal stem cells (MSCs) play a critical role in the growth and metastasis of hepatocellular carcinoma (HCC). However, the mechanism underlying the crosstalk between MSCs and HCC cells is not completely understood. Here, HCC cells were treated with or without conditioned medium of MSCs (CM-MSC), and examined for differential expression of long non-coding RNAs (lncRNAs).
View Article and Find Full Text PDFHOXA13 is a member of homeobox genes that encode transcription factors regulating embryonic development and cell fate. Abnormal HOXA13 expression was reported in hepatocellular carcinoma (HCC), but its correlation with tumor angiogenesis and prognosis still remain unclear. This study was aimed to uncover the expression, diagnostic and prognostic significance of HOXA13 in HCC.
View Article and Find Full Text PDFArticle Synopsis
- Homeobox B13 (HOXB13) is identified as an important factor in cellular differentiation, with recent studies linking its abnormal expression to cancer growth, particularly in hepatocellular carcinoma (HCC).
- In a study involving 72 HCC patients, researchers found that HOXB13 expression was significantly higher in cancerous tissues compared to non-tumor tissues, and was positively associated with factors like tumor angiogenesis and vascular invasion.
- Higher HOXB13 levels correlated with poorer survival outcomes, indicating it's a potential biomarker for assessing prognosis in HCC patients.
Gastrinoma is most commonly located in the gastrinoma triangle (comprising of the duodenum, pancreas and bile ducts) or in the adjacent lymph nodes. Due to the low mortality rate, it is often misdiagnosed as other diseases with similar clinical characteristics, such as a solid pseudopapillary tumor of the pancreas (SPTP). Therefore, the current study reports a rare case of gastrinoma located in the tail of the pancreas of a female patient under medical examination, who exhibited no clinical symptoms.
View Article and Find Full Text PDFRecent studies have found that periostin (PN), as a kind of secreted glycoprotein, is closely related to the metastatic potential and prognosis of many kinds of tumors. This study aimed to examine the expression of PN in patients with esophageal squamous cell carcinoma (ESCC) and explore the relationship of PN expression with clinicopathologic factors, tumor angiogenesis and prognosis. The results showed that increased PN protein expression was prevalent in ESCC and was significantly associated with lymphatic metastasis (P=0.
View Article and Find Full Text PDFBackground: Although hepatectomy is often performed with the Pringle maneuver, the problem of hepatic ischemia-reperfusion injury (HIRI) can also be serious. Thus, the present study was designed to investigate the protective effect of S-adenosylmethionine (SAMe) on HIRI, especially for patients with hepatocellular carcinoma (HCC) associated with chronic hepatitis B virus (HBV) infection and cirrhosis.
Methods: Eighty-one HCC patients with chronic HBV infection, undergoing partial hepatectomy with inflow occlusion, were divided into three groups.
Background: Recent studies have assessed the relationship between hypoxia-inducible factor 1α (HIF-1α) expression and prognosis in breast cancer patients with inconsistent conclusions. To comprehensively and quantitatively summarize the evidence on the survival of patients with breast cancer, a meta-analysis was performed.
Methods: Systematic literature searching was applied to the databases of PubMed, Embase and Web of science until April 1, 2013.
Article Synopsis
- - Peroxiredoxin 1 (Prdx1) is an antioxidant enzyme linked to important cell processes and was studied for its role in hepatocellular carcinoma (HCC) by examining its expression in 76 patients versus 20 healthy volunteers.
- - The study found that Prdx1 was significantly more expressed in HCC tissues compared to non-tumorous tissues and was associated with various clinicopathological features such as tumor size and stage.
- - Higher levels of Prdx1 were linked to poorer overall and disease-free survival in HCC patients, indicating it could be a valuable biomarker for diagnosis and prognosis when combined with serum alpha-fetoprotein (AFP).
Article Synopsis
- Periostin (PN) is a glycoprotein linked to the potential for tumors to spread and their prognosis, which is particularly examined in hepatocellular carcinoma (HCC).
- In a study involving 71 patients, it was found that PN was expressed significantly more in HCC tissues (73.2%) compared to nearby tissues (19.7%), linking it to factors like tumor nodules, microvascular invasion, and overall cancer staging.
- The study concluded that high levels of PN in HCC correlate with increased angiogenesis and a poorer prognosis, making it a potential independent predictor for survival outcomes in patients following surgery.