[Changes of heat-shock protein 70 in the brain of rabbits with craniocerebral missile injury in hot and humid environment].

Objective: To study the changes of heat shock protein 70 (HSP70) in the brain of rabbits with craniocerebral missile injury (CMI) and their impact on the injury in a hot and humid environment (HHE).

Methods: Twenty-four New Zealand white rabbits were randomized into 3 equal groups, namely normal temperature (NT) control group (subjected to treatment at temperature of 22.0+/-0.

[Changes of brain p38 MAPK in rabbits with craniocerebral gunshot injury in hot and humid environment].

Objective: To study the activation of p38 mitogen-activated protein kinase (MAPK) in the brain of rabbits after craniocerebral gunshot injury in a hot and humid environment (HHE) and explore its possible mechanism.

Methods: Craniocerebral gunshot injury model was established in 30 New Zealand white rabbits, which were subsequently exposed to environment of normal temperature (at 22.0% +/- 0.

[Effect of hyperthermia on tight junctions between endothelial cells of the blood-brain barrier model in vitro].

Objective: To investigate the effect of hyperthermia in vitro on tight junctions between the endothelial cells of the blood-brain barrier.

Methods: An in vitro blood-brain barrier model was established by coculture of ECV304 cells with astrocytes. Transendothelial resistance (TER) of in vitro blood-brain barrier was determined by Millicell-ERS system, and the morphological change of tight junctions examined by silver staining.