Publications by authors named "Qi-chang Wu"
Autosomal recessive microcephaly and chorioretinopathy (MCCRP) is a neurodevelopmental disorder characterized by delayed psychomotor development, growth retardation with dwarfism, and ocular abnormalities, and its occurrence has been found to be closely related to variants of the gene encoding centrosomes. However, the association between centrosomal duplication defects and the etiology of microcephaly syndromes is poorly understood. It is well known that polo-like kinase 4 (PLK4) is a key regulator of centriole duplication, and the abnormalities of centrosomal function caused by its protein variation need to be further explored in the pathogenesis of microcephaly.
View Article and Find Full Text PDF[Genetic counseling and clinical outcome of fetus with de novo chromosomal aberrations].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
February 2011
Article Synopsis
- The study aimed to analyze chromosome rearrangements in fetuses identified through prenatal diagnosis to improve genetic counseling on de novo chromosomal aberrations.
- Over a four-year period, 12 cases of de novo chromosomal abnormalities were found among 2,583 prenatal cytogenetic analyses, with a majority being unbalanced translocations, leading to a variety of clinical outcomes.
- The findings suggest that extensive cytogenetic and molecular studies, along with fetal ultrasound examinations, can help predict the health outcomes of pregnancies affected by these chromosomal issues.
Background: Nasopharyngeal carcinoma (NPC) shows highly invasive and metastatic features. This study aims to investigate macrophage migration inhibitory factor (MIF)-induced invasion of NPC cells in vitro and the effects on matrix metalloproteinases (MMPs) and interleukin-8 (IL-8), and to study the mechanism of tumor cell invasion and metastasis in the early stage of NPC.
Methods: Two nasopharyngeal carcinoma cell lines, CNE-1 and CNE-2, were adopted in this study.