Berberine ameliorates depression-like behavior in CUMS mice by activating TPH1 and inhibiting IDO1-associated with tryptophan metabolism.

Berberine, which is a potential antidepressant, exhibits definite efficiency in modulating the gut microbiota. Depressive behaviors in mice induced using chronic unpredictable mild stress (CUMS) stimulation were evaluated by behavioral experiments. The markers of neurons and synapses were measured using immunohistochemical staining.

Vagus nerve stimulated by microbiota-derived hydrogen sulfide mediates the regulation of berberine on microglia in transient middle cerebral artery occlusion rats.

Amelioration of neuroinflammation via modulating microglia is a promising approach for cerebral ischemia therapy. The aim of the present study was to explore gut-brain axis signals in berberine-modulating microglia polarization following cerebral ischemia. The potential pathway was determined through analyzing the activation of the vagus nerve, hydrogen sulfide (H S) metabolism, and cysteine persulfides of transient receptor potential vanilloid 1 (TRPV1) receptor.

Involvement of Huanglian Jiedu Decoction on Microglia with Abnormal Sphingolipid Metabolism in Alzheimer's Disease.

Background: Abnormal sphingolipid metabolism is closely related to the occurrence and development of Alzheimer's disease (AD). With heat-clearing and detoxifying effects, Huanglian Jiedu decoction (HLJDD) has been used to treat dementia and improve learning and memory impairments.

Purpose: To study the therapeutic effect of HLJDD on AD as it relates to sphingolipid metabolism.

Potential Mechanism of on Lipid Metabolism Explored via Network Pharmacology and Untargeted Lipidomics.

Background: , a traditional herb, has great potential in treating diseases associated with aberrant lipid metabolism, such as inflammation, hyperlipidemia, atherosclerosis and Alzheimer's disease.

Aim Of The Study: To elucidate the mechanism by which modulates lipid metabolism and explore the medicinal effects of at a holistic level.

Materials And Methods: The potential active ingredients of and targets involved in regulating lipid metabolism were identified using a network pharmacology approach.

Analysis of Antidepressant Activity of Huang-Lian Jie-Du Decoction Through Network Pharmacology and Metabolomics.

Depressive disorder is a common mental disorder characterized by depressed mood and loss of interest or pleasure. As the Herbal medicines are mainly used as complementary and alternative therapy for depression. This study aimed at exploring antidepressant activity of Huang-lian Jie-du Decoction (HLJDD), and evaluating active components and potential depression-associated targets.

[Influence of preventive surgery intervention on life quality of patients with advanced schistosomiasis].

Objective: To investigate the influence of preventive pericardial devascularization on the life quality of patients with advanced schistosomiasis.

Methods: The clinical data of advanced schistosomiasis patients who received the preventive pericardial devascularization from January 2000 to December 2009 (140 cases) were collected and analyzed retrospectively, and other 81 cases without preventive pericardial devascularization served as controls. Results Compared with that of the control group, the long term upper gastrointestinal rebleeding within 3 years of the study group was much fewer (P < 0.