Neuroprotection of cordycepin in NMDA-induced excitotoxicity by modulating adenosine A receptors.

Cerebral ischemia impairs physiological form of synaptic plasticity such as long-term potentiation (LTP). Clinical symptoms of cognitive dysfunction resulting from cerebral ischemia are associated with neuron loss and synaptic function impairment in hippocampus. It has been widely reported that cordycepin displays neuroprotective effect on ameliorating cognitive dysfunction induced by cerebral ischemia.

Short pulse-width gain-switched Ho:YAG ceramic laser at ∼2.09 μm.

This paper presents a short pulse-width gain-switched Ho:YAG ceramic laser at 2089 nm resonantly pumped by a homemade Q-switched Tm:fiber laser at ∼1908  nm. We generated stable pulses of 44-103 ns duration and 0.13-2 kW peak power at 20 kHz of pulse repetition frequency when the incident pump pulse energy increased from ∼0.

Effects of intrahippocampal GABAB receptor antagonist treatment on the behavioral long-term potentiation and Y-maze learning performance.

GABAB receptor is present at pre- and post-synaptic sites and participates in many brain functions including cognition, reward and anxiety. Although a lot of research has shown that activation or blockade of GABAB receptor may produce different even opposing effects on long-term potentiation (LTP) and cognitive function, there is little information available concerning the effect of GABAB receptor on behavioral LTP, a learning-induced LTP model. Herein, we firstly examined the effects of 2-OH saclofen, a GABAB receptor antagonist, on the induction of behavioral LTP and Y-maze learning performance.