Technol Cancer Res Treat
January 2024
The development of 1,8-naphthalimide derivatives as cell probes, DNA targeting agents, and anti-tumor drugs is one of the research hotspots in the field of medicine. Naphthalimide compounds are a kind of DNA embedder, which can change the topological structure of DNA by embedding in the middle of DNA base pairs, and then affect the recognition and action of topoisomerase on DNA. Aminofide and mitonafide are the first 2 drugs to undergo clinical trials.
View Article and Find Full Text PDFSeventeen undescribed sesquiterpene-alkaloid hybrids (liriogerphines E-U, 1-17) were isolated and identified during a further phytochemical investigation on the branches and leaves of Chinese tulip tree (Liriodendron chinense), a rare medicinal and ornamental plant endemic to China. These unique heterodimers are conjugates of germacranolide-type sesquiterpenoids with structurally diverse alkaloids [i.e.
View Article and Find Full Text PDFLiriogerphines A-D (, respectively), an unprecedented class of hybrids of germacranolide-type sesquiterpenoids and aporphine-type alkaloids, were isolated from the rare medicinal plant . Their structures were elucidated by comprehensive spectroscopic analyses combined with electronic circular dichroism calculations and X-ray crystallographic data. Biosynthetically, an aza-Michael addition reaction is proposed to be involved in the assemblies of this class of hybrids.
View Article and Find Full Text PDFObjective: To analyze the compositions of the essential oil from the rhizome of Curcuma aromatica in Guangxi.
Methods: The essential oil from the rhizome of Curcuma aromatica was extrated by steam distillation and analysed by GC-MS.
Results: 50 chemical constituents accounting for 93.
Zhongguo Zhen Jiu
December 2007