Toxicity and risk assessment of mercury exposures from cinnabar and Baizi Yangxin Pills based on pharmacokinetic and tissue distribution studies.

Ethnopharmacological Relevance: Baizi Yangxin Pills (BZYXP), a popular cinnabar (α-HgS) contained Traditional Chinese Medicines (TCMs) is widely used in clinical trials. However, mercury is one of the most toxic elements. The adverse effects of cinnabar-containing TCMs have been occasionally reported in recent years, leading to the growing concerns about their toxicity and safety.

Separation and identification of process-related substances and degradation products in mycophenolate mofetil by liquid chromatography coupled with quadrupole-time of flight mass spectrometry.

Mycophenolate mofetil is an antiproliferative immunosuppressive agent. Since its clinical efficacy and safety highly depend on the quality, the stability, and impurity profiles of mycophenolate mofetil are paid ever-increasing attention. However, there are few published studies reporting the complete characterization of both the process-related substances and degradation products in mycophenolate mofetil.

Insights into the structural, electronic and magnetic properties of V-doped copper clusters: comparison with pure copper clusters.

The structural, electronic and magnetic properties of Cun+1 and CunV (n = 1-12) clusters have been investigated by using density functional theory. The growth behaviors reveal that V atom in low-energy CunV isomer favors the most highly coordinated position and changes the geometry of the three-dimensional host clusters. The vibrational spectra are predicted and can be used to identify the ground state.

[Effects of wide band frequency noise on NMDAR1(zeta 1), NMDAR2A(epsilon 1) subunit and ABR threshold in the different area of brain of AD rats poisoned by glutamic acid].

Aim: To investigate the change of NMDAR1 (zeta 1) subunit expression in temple cortex, frontal lobe, hippocampus and cerebellum of three different group rat after 98 dB wide frequency noise exposure.

Methods: Western Blot and RT-PCR technique, combined with auditory brainstem response (ABR) measurement.

Results: (1) Expressions of NMDAR1 (zeta 1) subunit in frontal cortex, temple cortex, hippocampus and cerebellum have no difference, but AD model rat is much weaker than the control group.

[Effects of wide band frequency noise on ERK, GDNF and ABR threshold in the different area of brain of AD rats poisoned by glutamatic acid].

Aim: To investigate the change of ERK, GDNF expression activity in temple and frontal lobe of AD rat after 96 dB wide band noise exposure.

Methods: Experimental group SD rats(weight from 150-220 g), either male or female, were randomly assigned to three groups: control (n=10); physiological brine-injected control (n=8); glutamic acid-injected group (n=8) after getting rid of memory loss(indicating "a little memory" and "no memory") rats culled by behavior training. The rats were micro-injected at the stereotaxic device (AP3.