Publications by authors named "Qi-Wen Xiao"
Dis Markers
November 2022
Article Synopsis
- The study identified high levels of MCF2L in hepatocellular carcinoma (HCC) tissues, suggesting it plays a role in resistance to sorafenib, a common cancer treatment.
- Various experiments confirmed that reducing MCF2L levels increased cell death when treated with sorafenib, and that this process is linked to ferroptosis, a specific type of cell death.
- The research also indicated that MCF2L influences the PI3K/AKT signaling pathway via a RhoA/Rac1-dependent mechanism, making it a potential target for overcoming treatment resistance in HCC.
