Nomogram for predicting early death in elderly patients with laryngeal squamous cell carcinoma: A population-based SEER study.

Background: The disease and mortality rates of patients with laryngeal squamous cell carcinoma (LSCC) stabilize after peaking at the age of 60 years. This study aimed to identify risk factors associated with early death (death within 6 months) in elderly (≥60 years) patients with LSCC and to establish predictive nomograms to aid clinicians in developing individualized treatment plans.

Methods: Data pertaining to elderly patients with LSCC between 2004 and 2015 was obtained from the Surveillance, Epidemiology, and End Results database (version 8.

Integrated analysis of methylation and transcriptome identifies a novel risk model for diagnosis, prognosis, and immune characteristics in head and neck squamous cell carcinoma.

Background: DNA methylation is an important epigenetic modification that plays a crucial role in the development and progression of various tumors. However, the association between methylation‑driven genes and diagnosis, prognosis, and immune characteristics of head and neck squamous cell carcinoma (HNSCC) remains unclear.

Methods: We obtained transcriptome, methylation, and clinical data from HNSCC patients in TCGA database, and used MethylMix algorithm to identify methylation-driven genes.

Identifying optimal candidates for primary tumor surgery in patients with metastatic head and neck cancer.

Background: Primary tumor surgery (PTS) may enhance survival among part of patients with metastatic head and neck cancer (mHNC). Herein, a predictive model was needed to construct to identify who can gain benefit remarkably from tumor resection.

Methods: Data of patients with mHNC were extracted from the Surveillance, Epidemiology, and End Results (SEER) database.

Targeting PI3Kα overcomes resistance to KRas inhibitors mediated by activation of EGFR and/or IGF1R.

Although several KRas inhibitors have displayed promising efficacy in clinical settings, acquired resistance developed rapidly and circumvented the activity of KRas inhibitors. To explore the mechanism rendering acquired resistance to KRas inhibitors, we established a series of KRAS-mutant cells with acquired resistance to AMG510. We found that differential activation of receptor tyrosine kinases (RTKs) especially EGFR or IGF1R rendered resistance to AMG510 in different cellular contexts by maintaining the activation of MAPK and PI3K signaling.

Impact of prior cancer history on survival of patients with hypopharyngeal cancer.

Background: The impact of prior cancer history on survival of hypopharyngeal cancer patients remains unknown. The present study assessed the impact of prior cancer history on survival of patients with hypopharyngeal cancer.

Methods: Patients with primary hypopharyngeal cancer diagnosed between 2004 and 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database.

Comparison of Survival Outcomes of Different Treatment Options for cT1-2, N0 Glottic Carcinoma: A Propensity Score-Weighted Analysis.

Background: Treatments for cT1-2, N0 glottic squamous cell carcinoma (GLSCC) include endoscopic resection, open surgery, and radiotherapy. The purpose of this study was to compare the outcomes of three treatment modalities and provide reference data for treatment selection.

Methods: In all, 4274 patients with cT1-2, N0 GLSCC underwent these three treatment modalities from 2004 to 2015 were identified from the Surveillance, Epidemiology, and End Results-18 database.

Covalent inhibitor targets KRas: A new paradigm for drugging the undruggable and challenges ahead.

is one of the most commonly mutated oncogenes in cancers and therapeutics directly targeting the KRas have been challenging. Among the different known mutants, KRas has been proved to be successfully targeted recently. Several covalent inhibitors selectively targeting KRas have shown promising efficacy against cancers harboring mutation in clinical trials and AMG510 (sotorasib) has been approved for the treatment of -mutated locally advanced or metastatic non-small cell lung cancer.

Postharvest biochemical characteristics and ultrastructure of .

Background: is a novel cultivated edible fungus, hailed as a new preeminent breed of mushroom. However, is difficult to keep fresh at room temperature after harvest due to high respiration, browning, self-dissolve and lack of physical protection.

Methods: In order to extend the shelf life of and reduce its loss in storage, changes in quality, biochemical content, cell wall metabolism and ultrastructure of (77) under 4 °C and 90% RH storage regimes were investigated in this study.

Comparative study on the composition of four different varieties of garlic.

Garlic is used as a medicinal seasoning worldwide. The aim of this work was to compare four varieties of garlic: 'Taicangbaipi', 'Ershuizao', 'Hongqixing', and 'Single-clove'; among them, 'Ershuizao' and 'Hongqixing' are unique to the Sichuan Province of China. Firstly, soluble sugar, starch, and the protein content of the garlic were analysed.

Characterization of wheat - Psathyrostachys huashanica small segment translocation line with enhanced kernels per spike and stripe rust resistance.

Psathyrostachys huashanica Keng (2n = 2x = 14, NsNs), a distant wild relative of common wheat, possesses rich potentially valuable traits, such as disease resistance and more spikelets and kernels per spike, that could be useful for wheat genetic improvement. Development of wheat - P. huashanica translocation lines will facilitate its practical utilization in wheat breeding.