Publications by authors named "Qi-Tao Zhan"
Article Synopsis
- - Agenesis of the corpus callosum (ACC) is a birth defect where the corpus callosum is partially or completely absent, and recent ultrasound advancements are improving its detection during pregnancy.
- - Various causes behind ACC include chromosome errors, genetic factors, prenatal infections, and environmental influences during pregnancy.
- - Whole-exome sequencing (WES) has helped identify specific gene mutations linked to complete ACC in two families, offering a more effective way to diagnose the condition through genetic and imaging methods.
Article Synopsis
- Most children conceived through assisted reproductive technology (ART) are healthy, but there are concerns about potential long-term health effects associated with ART.
- Research using mouse models shows that certain gene alterations linked to heart and metabolic issues are present in mice conceived through ART methods like ICSI and IVM.
- Findings indicate that older mice conceived by ICSI or IVM have higher blood pressure and abnormal lipid levels, suggesting a risk for cholesterol metabolism problems later in life due to ART.
Over the course of the past 35 years, assisted reproductive technologies (ARTs) have been increasingly used worldwide, while debates on their safety have been generated. Birth defects and imprinting disorders were reported in previous research. Thus, the psychological development of children born following ARTs has become a major concern nowadays.
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- Infertility linked to metabolic syndrome has a global prevalence of 10%-20%, as noted by the World Health Organization.
- Evidence suggests that the renin-angiotensin system plays a significant role in fertility issues across populations.
- Alterations in angiotensin-converting enzymes may contribute to infertility in both genders, but further research is necessary to determine the impact of the angiotensin-converting enzyme-3 pseudogene on human reproduction.
In vitro maturation (IVM) of oocyte is an effective procedure for avoiding ovarian hyperstimulation syndrome in patients with polycystic ovaries (PCOS) during in vitro fertilization (IVF). To investigate the influences of IVM on epigenetic reprogramming and to search for the possible reasons for the lower rates of fertilization and cleavage in IVM oocytes, we examined the expression of two enzymes controlling histone acetylation, histone acetyltransferase GCN5 (GCN5) and histone deacetylase 1 (HDAC1), as well as their common target, acetyl-histone H3 (Ac-H3), in mouse metaphase II (MII) oocytes and preimplantation embryos. Results showed that IVM downregulated the protein expression of GCN5 in MII oocytes and two-cell embryos and changed the distribution of GCN5 in two-cell embryos.
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