Smart bio-gel optofluidic Mach-Zehnder interferometers multiphoton-lithographically customized with chemo-mechanical-opto transduction and bio-triggered degradation.

Stimulus-responsive optical polymers, especially gels, are enabling new-concept energy-transducing "smart" optics. Full exploitation of their molecule-derived tuning and integration with traditional micro/nano-optics/optoelectronics rely on the implementation of devices by advanced "intelligent" micro/nano-manufacturing technologies, especially photolithographies with wide compatibility. In light of the increasing need for an organic combination of smart optical materials and digital micro/nano-manufacturing, novel "smart" optical micro-switches, namely, stimulus-actuated Mach-Zehnder interferometers as a proof-of-concept demonstration, were prototyped with protein-based hydrogels via aqueous multiphoton femtosecond laser direct writing (FsLDW).

Monolithic bifocal zone-plate lenses for confocal collimation of laser diodes.

An elliptical monolithic bifocal zone plate as a collimating lens, whose two focal lengths in the orthogonal directions match the different beam waist positions of the fast and slow axes' light from edge-emitting laser diodes, is proposed and experimentally demonstrated by employing femtosecond laser direct writing technology. The high-quality eight-level zone plate exhibits a diffraction efficiency of 92.9%, which is much higher than those ever reported.

Residual hepatocellular carcinoma after oxaliplatin treatment has increased metastatic potential in a nude mouse model and is attenuated by Songyou Yin.

Background: The opposite effects of chemotherapy, which enhance the malignancy of treated cancers such as hepatocellular carcinoma (HCC), are not well understood. We investigated this phenomenon and corresponding mechanisms to develop a novel approach for improving chemotherapy efficacy in HCC.

Methods: Human hepatocellular carcinoma cell lines HepG2 (with low metastatic potential) and MHCC97L (with moderate metastatic potential) were used for the in vitro study.

Herbal extract "Songyou Yin" inhibits tumor growth and prolongs survival in nude mice bearing human hepatocellular carcinoma xenograft with high metastatic potential.

Purpose: Chinese herbs have become a focus of interest in cancer treatment. This study evaluates the effect of the herbal compound extract "Songyou Yin" (containing Salvia miltiorrhiza Bge.-danshen and other four herbs) on hepatocellular carcinoma (HCC).