Publications by authors named "Qi-Sheng Zhong"
Article Synopsis
- The sigma glutathione S-transferases (GSTSs), essential in antioxidant defense for insects, have unclear mechanisms of action, prompting a study of a specific GSTS (GSTS6) from Tribolium castaneum.
- Researchers found that TcGSTS6 exhibits high activity in responding to oxidative stress and is significantly induced by various stress types, indicating its role in antioxidant defense.
- The study also revealed that TcGSTS6 is crucial for detoxifying insecticides and embryogenesis, enhancing our understanding of GSTS functional diversity in insects.
Serum polyunsaturated fatty acid metabolites as useful tool for screening potential biomarker of colorectal cancer.
Prostaglandins Leukot Essent Fatty Acids
May 2017
The biomarker identification of cancer is benefit for early detection and less invasion. Polyunsaturated fatty acid (PUFA) metabolite as inflammatory mediators can affect progression and treatment of cancer. In this work, the serum was collected from colorectal cancer patients and healthy volunteers, and then we tested the change of serum PUFA metabolites in both of them by ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS).
View Article and Find Full Text PDFArticle Synopsis
- Smad3 is a key player in the signaling process for transforming growth factor β, which is involved in inflammation and immunity; its role in regulating iNOS expression during septic shock is not well understood.
- In experiments, Smad3 knockout (KO) mice showed higher mortality and more severe hypotension after being injected with lipopolysaccharide (LPS) compared to wild-type (WT) mice, indicating that the absence of Smad3 increases vulnerability to septic shock.
- Both KO and WT mice had increased levels of plasma nitrite and iNOS expression after LPS treatment, but KO mice exhibited significantly greater increases, suggesting that defects in Smad3 lead to heightened iNOS production and susceptibility to septic hypot